Abstract
Among the three main schistosomes (Schistosoma japonicum, Schistosoma mansoni, and Schistosoma haematobium) known to infect humans, S. japonicum causes the most serious pathological lesions. In China, only schistosomiasis japonica is transmitted. From the 1950s, massive epidemiological investigations and active control measures for schistosomiasis japonica have been carried out. At the early stage of schistosomiasis control program, there were about 12 million schistosomiasis patients, and about 5 % of schistosomiasis patients belong to advanced patients, which was 600,000. After more than a half century of active schistosomiasis control work, the schistosomiasis situation has been reduced markedly. The nearest epidemiological investigation showed that, by the end of 2012, there were still 240,000 schistosomiasis patients with the descent rate of 98 % and 30,000 advanced patients with the descent rate of 95 %. This paper reviews the rich experiences of advanced schistosomiasis research and control in China, including that the epidemiology researches confirm there is a family aggregation of advanced schistosomiasis and advanced schistosomiasis patients have no significance to the schistosomiasis transmission in transmission-interrupted areas but still are an infection source in endemic areas; pathogenic mechanism researches verify that genetic factors and immunoregulation play important roles in the disease developing process; ultrasound image examinations are used not only in the diagnosis and differential diagnosis of advanced schistosomiasis but also in the guidance of treatment and evaluation of therapeutic effects and, furthermore, in the risk predictions of portal hypertension and upper gastrointestinal hemorrhage; clinical practices demonstrate that praziquantel can be used in most of advanced schistosomiasis patients, and the therapy not only can interrupt the schistosomiasis transmission somewhat but also is favorable for liver fibrosis improvement; the ascetic fluid concentration afflux is used in the therapy for obstinate ascites, and endoscopic varices ligation is used in the treatment of upper gastrointestinal bleeding, and both have good effects; hundreds and thousands of severe splenomegaly advanced schistosomiasis patients received splenectomy, and the long-term survival rate is more than 90 %, most of them are basically cured from the disease and their labor force recovers, some dwarf patients begin growing and developing again, and some sterile women became fertile; the researches of traditional Chinese medicine in the treatment of liver fibrosis have made progress, such as Cordyceps sinensis showing some anti-fibrosis effect in the animal experiments and primary clinical trials; the animal experiments and epidemiological investigations indicate that schistosome infection is one of the carcinogenesis risk factors, especially for liver cancer. In conclusion, these experiences and lessons are plentiful and worth sharing with the peers of other endemic countries for reference.
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References
Cai WM, Zhang LH, Liu RH, Fu BZ, Wu WL, Huang YY (1992) Big dosage of Cordyceps sinensis in treatment of ascites of advanced schistosomiasis. Clin Pharm 12:157–158
Chang FH, Chen ZF, Gao RB (1998) Therapeutic effect of Cordyceps sinensis in treatment of advanced schistosomiasis: a report of 53 cases. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 10:355–356
Chapadeiro E, Pitanga LC (1996) On the reversal of schistosomiasis hepatic fibrosis after specific therapy. Histopathologic study. Rev Soc Bras Med Trop 30:53–56
Chen YX (1986) Long-term therapeutic effect of splenectomy of advanced schistosomiasis: a report of 300 cases. Jiangsu Med 12:156
Chen HS, Chen J, Yang YX, Kong MY (1992) Value of liver biopsy in diagnosis of advanced schistosomiasis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 4:377
Chen YL, Xu MX, Song WJ, Yang Y, Liu WQ, Li YL, Qiu MY, Wu H (2005) Microarray DNA chip analyzing the association between HLA-DRB advanced hepatosplenic schistosomiasis. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 23:392–395
Chen DL, Zhu JJ, Liu BA, Zong DM, Li J, Zhao XG (2009) Correlation between the index of liver fibrosis and histopathology in patients with advanced schistosomiasis. Shandong Med 49:11–13
Deng Y, Jia TW, He WL, Ou-yang SW, He SH, Zhou XN (2009) Study on social burden caused by advanced schistosomiasis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 21:107–110
Department of Diseases Control, Ministry of Health, People’s Republic of China (2000) Manual of schistosomiasis control, 3rd edn. Press of Science and Technology of Shanghai, Shanghai, pp 108–113
Du H (2007) Advanced schistosomiasis combined with liver cancer: a report of 51 cases. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 19:195–196
Dunn MA, Cheever AW, Paglia LM, Kelly EP, Duvall RH, Andrade ZA, Goldner FH (1994) Reversal of advanced liver fibrosis in rabbits with schistosomiasis japonica. Am J Trop Med Hyg 50:499–505
Gao YF (1992) Long-term therapeutic effect of surgery of advanced schistosomiasis patients with portal hypertension: a report of 489 cases. Acta Fujian Med Colg 26:239–241
Gui XE, Luo MQ, Xu QB, Yang ZC, Zhang CR, Jiang YZ (1997) A clinical and pathological study on patients with splenomegalic advanced schistosomiasis. Zhongguo Ji Sheng Chong Bing Fang Zhi Za Zhi 10:27–31
Guo ZR, Jiang GX, Lu QX (1993) A study on relationship between schistosomiasis japonica and malignancy. Tumor 13:105–108
Guo JD, Li QY, Ying XM, Zhou L, Shen GJ, Wu WD, Han XH, Zheng FT (2002) Analysis of the quality of life scale for patients with advanced schistosomiasis. Chi J Behav Med Sci 11:382–384
He YW, Liu W, Zen LL, Luo DD (1996a) The effect of C-interferon on hepatic fibrosis in schistosomiasis japonica. Chin Med J 76:371–374
He YW, Liu W, Zeng LL, Luo DD (1996b) The effect of γ-interferon on hepatic fibrosis in schistosomiasis japonica. Chin Med J 76:371–374
He YW, Liu W, Zen LL, Luo DD (1997a) Effects of γ-interferon on hepatic fibrosis of Schistosoma japonicum-infected mice. China Natl J New Gastroenterol 3:6–8
He YW, Luo DD, Liu W (1997b) The effect of pHGF on TNF in liver and hepatic fibrosis in schistosomiasis japonica. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 9:15–18
He YW, Liu FC, Luo DD, Zeng LL, Li SL, Liu W (2001a) The effect of prostaglandin E1 on hepatic fibrogenesis in rats with schistosomiasis japonica. Zhongguo Ji Sheng Chong Bing Fang Zhi Za Zhi 14:142–144
He YW, Liu FC, Luo DD, Zeng LL, Li SL, Liu W (2001b) The effect of prostaglandin E1 on hepatic fibrosis in rats with schistosomiasis japonica. Zhongguo Ji Sheng Chong Bing Fang Zhi Za Zhi 14:142–144
Hua HY, You H, Zhang Y, Tang F, Zhu ZQ, Gao Y, Yang HQ, Liang YS (2010) Evaluation of quality of life in advanced schistosomiasis patients in Jiangsu Province. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 22:562–566
Huang GZ (2006) Therapeutic effect of ascites afflux in treatment of obstinate ascites in advanced schistosomiasis patients. J Clin Res 23:778–779
Huang LX, Liu BY, Sun KY, Yi ZS, Hou XY, Liu JX (1994) Discussion of portal vein ultrasonography in risk predictions of upper gastrointestinal hemorrhage of advanced schistosomiasis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 6:355–356
Huang LG, Ren XC, Li RQ, Tang YN, Din CZ, Liu FF (1998) Clinical value of determination of serum hyaluronic acid in advanced schistosomiasis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 10:218–220
Huang YX, Rong GR, Wang DW, Tu YX, Zhao YJ, Hu XS (2000) A ten-year follow-up study on advanced schistosomiasis japonica in Jiangsu Province. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 12:129–133
Jiang GR, Guo ZR (1999) The relationship between schistosomiasis japonica and mortality of liver cancer. Guangxi Prev Med 5:5–7
Jiang JW, Zhong CS, Yu YF, Wei CC, Xu ZY (1990) Ultrastructural studies on effects of colchicine in treating hepatic fibrosis of schistosomiasis rabbits. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 8:84–87
Jiang J, Zhong C, Yu Y, Zhang Q (1996) Colchicine reduces hepatic fibrosis in mice infected with Schistosoma japonicum. Chin Med J 109:795–800
Jin PM, Zhou MH, Sheng GG, Wang L, Yu TP, An YN (1992) Further observation on Xinganbao (Cordyceps sinensis) therapy for liver fibrosis caused by advanced schistosomiasis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 4:380
Jin WE, Zhang PX, Xiong P, Xiao DT, Huang HF, Du TK, Luo YX, Wang HC, Gui JK, Fan HM (1993) The practical value of two hepatic cirrhosis biochemical markers on the identification of advanced schistosomiasis. J Pract Parasit Dis 1:40–42
Jin MY, Liu X, Zhang JJ, Chen FX, Shi JR, Fang YR, Fu FY, Zhang MZ, Chen JL, Wei XP (1994) Long-term follow-up study of advanced schistosomiasis in schistosomiasis-controlled area. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 7:190–193
Li WX, Sun KY (2006) Comparative analysis of ultrasonic evidences and serological findings of schistosomiasis liver fibrosis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 18:128–130
Li WM, Xu YB (1993) Long-term curative effect of splenectomy of advanced schistosomiasis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 5:355–357
Li ZJ, Luo DD, Liu SC, Yang YX, Yang Q, Zheng LLISL, Dai JZ, Wang XH (1991) Detection of γ-interferon in spleen of patients with advanced schistosomiasis japonica and its significance. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 3:206–208
Li SN, Chen DL, Zhu JJ, Zong DM (2011) Value of serum TGF-β1, MMP-1, TIMP-1 detection in the diagnosis of liver fibrosis in advanced schistosomiasis and their significance. China Trop Med 11(992):999
Li SZ, Zheng H, Gao J, Zhang LJ, Zhu R, Xu J, Guo JG, Xiao N, Zhou XN (2013) Endemic status of schistosomiasis in People’s Republic of China in 2012. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 25:557–563
Liao HB, Chang MX, Xie JH (2011) Therapeutic efficiency of Anluo Huaxian Wan in treatment of patients with advanced schistosomiasis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 23:317–318
Lin DD, Wang YH, Qin B, Zhang SJ, Li JY (1995) Correlation analysis between schistosomiasis and liver cancer in Jiujiang District of Jiangxi Province. Zhongguo Ji Sheng Chong Bing Fang Zhi Za Zhi 8:184–187
Liu Y, Yuan HC, Lin DD, Hu F, Liu YM, Zhang SJ, Zhao GM, Jiang QW (1999) Study on family aggregation of cases of advanced schistosomiasis japonica. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 17:149–151
Liu FC, He YW, Luo DD, Zeng LL, Li SL (2002) Study on the relationship between prostaglandin E1 and hepatic fibrosis in rats with schistosomiasis japonica. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 14:8–10
Liu JX, Li ZC, Cai DY (2009) Surgical treatment of splenomegaly advanced schistosomiasis. In: Ren GH (ed) Clinical schistosomiasis. People’s Medical Publishing House, Beijing, pp 446–459
Liu LQ, Zhou ZY, Wang ZM, Zhang J, Tian YX, Hu H (2013a) Endoscopic variceal ligation in prevention from esophageal variceal hemorrhage of advanced schistosomiasis patients. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 25:218–219
Liu R, Dong HF, Jiang MS (2013b) The new national integrated strategy emphasizing infection sources control for schistosomiasis control in China has made remarkable achievements. Parasitol Res 112:1483–1491
Ning A, Wu X, Li H, Liang J, Gao Z, Shen J, Liu Z, Xu J, Hu F, Wu F, Ji P, Wu Z, Sun X (2014) Abnormal liver function in different patients with Schistosoma japonicum. Parasitol Res Epub ahead of print
Niu CS, She HB (2013) Correlation between liver fibrosis serological indicators and B ultrasonic examinations in advanced schistosomiasis patients. Clin Blood Transfus Lab Sci 15:245–246
Niu XH, Wu PF, Hua HY, Huang LH, Wu HY, Zhu HY, Yang XJ, Yao SZ, Li YG, Qiu YW (2011) Therapeutic effect of Dahuangzhechong pills on advanced schistosomiasis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 23:701–703
Niu XH, Hua HY, Guo WJ, Zhang Y, Liu M, Hong Y, Wu PF, Lu P, Zhang HF (2013) Clinical efficiency of tanshinone IIA-sulfonate in treatment of liver fibrosis of advanced schistosomiasis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 25:137–140
Pan RH, Wang FL (2002) Far effect of combination of splenectomy with devascularization for advanced schistosomiasis portal hypertension. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 14:459–460
Peng YZ, Zhang YH, Xiang MF, Deng B, Huang QT (1999) Comparison of effects on ultromicrostructure of liver tissue in rabbit with liver fibrosis of schistosomiasis treated with RNA and malotilate. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 11:336–339
Qian YN, Zhou MH, Shang GG, Wei BR, Hua HY, Wang DW, Liu MT, He GM, Liu BY, Zhao BY (1991) Observations on Xinganbao (Cordyceps sinensis) therapy of liver fibrosis caused by advanced schistosomiasis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 3:267–270
Qian ZX, Ying JJ, Zhou MT, Ge YC (2002) Long-term follow-up of splenectomy plus portosystemic shunt in the treatment of portal hypertension in patients with schistosomal cirrhosis. China J Hepatobiliary Surg 8:22–24
Qin B, Yang X, Wei SJ, Wang YH (1998) Analysis of serological examinations in 545 advanced schistosomiasis patients. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 10:293
Qiu DC, Zhang GS, Wen S, Zhang Y, Wu ZS, Cui LN, Shan JZ, Cai XP, Li MS (2000) Observation on changes of liver fibrosis due to Schistosoma japonicum after treatment with praziquantel. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 12:138–140
Shao JM, Wang DW, Wang SL (1998) Report of B ultrasonic examinations in 2546 advanced schistosomiasis patients. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 10:234–236
Shen KN, Yao YR, Wu YX (1980) Long-term therapeutic effect of surgery of advanced schistosomiasis: a report of 522 cases. Guangxi Hyg 2:1–2
Shi YY (1995) Long-term curative effect of splenectomy of splenomegaly advanced schistosomiasis patients: a report of 544 cases. Zhongguo Ji Sheng Chong Bing Fang Zhi Za Zhi 8:136
Sun Y, Xu DB, Zhang KK (2011) Analysis of 728 advance schistosomiasis cases. Anhui J Prev Med 17:132
Wang AL (1994) Clinical analysis of advanced schistosomiasis combined with hepatic carcinoma: a report of 46 cases. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 6:125
Wang ZH (1999) Review of anti-fibrosis medicine for advanced schistosomiasis. Hubei J Prev Med 10:20–21
Wang WS, Li YL (2000) Studies on relationship between immune inhibition and apoptosis of T cells in mice infected with Schistosoma japonicum. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 12:257–260
Wang DZ, Zhuang QP (1985) Long-term therapeutic efficacy of splenectomy of advanced schistosomiasis. Shanghai Med 8:540–541
Wang CG, Zhu QY, Hang PY, Zhu YW (1982) Relationship between schistosomiasis japonica and major histocompatibility antigens. Jiangsu Med 8:527–530
Wang HZ, Jia YD, Guo JP, Xia C (1989) Review of schistosomiasis control for 40 years in China. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 1:1–4
Wang YH, Fei HL, Xiong ZM, Shen YF, Li YL (1992) Effect of propranlolum on pulse pressure during splenectomy in advanced schistosomiasis patients. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 4:155–156
Wang WX, Chen HS, Wang ZB (1995) Therapeutic efficacy of endoscopic variceal ligation in treatment of esophageal varicosity of advanced schistosomiasis patients. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 7:39–41
Wang YZ, Shao Q, Pan BR, Li H (1997) Effects of malotilate on liver schistosome egg granuloma in mice with advanced schistosomiasis. Acta Acad Med Jiangxi 37:69–70
Wang MS, He ZG, Zhang WH (2013) Therapeutic effect of abdominal injection of dopamine and furosemide in treatment of obstinate ascites of advanced schistosomiasis. Parasitoses Infect Dis 11:167–168
Weng HL, Cai WM, Yang YH (2001) Dynamic changes in collagen type I and collagen type III in rabbits infected with Schistosoma japonicum and the effect of gamma-interferon. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 19:26–29
Wu W, Huang Y (2013) Application of praziquantel in schistosomiasis japonica control strategies in China. Parasitol Res 112:909–915
Wu XM, Zhuang WH, Zhang XH, Li H, Pan BR, Zhou LY (2000) Experiment of malotilate on liver fibrosis and immunity of advanced schistosomiasis patients. Pract Prev Med 7:70–71
Wu XH, Wang TP, Lu DB, Zhu CG, Fang GR, Wu WD, Ge JH, Zhang J (2002) Studies on physical fitness and working capacity of patients with advanced schistosomiasis japonica in Susong County. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 14:203–207
Wu WL, Zhou XZ, Huang YY, Shao PY, Yang YP, Xu XF (2004) Long term efficacy of pyquiton on schistosomiasis japonica. China J Infect Dis 22:238–241
Wu WD, Wang TP, Zhang SQ, Sheng GJ, Guo JD, Xiao X, Luo JP (2007) A follow-up investigation on 270 cases of advanced schistosomiasis with surgical treatment in Anhui Province. J Trop Dis Parasitol 5:23–26
Xiong YK, Yang GY (2001) Clinical observation on nifedipine and propranlolum in treatment of portal hypertension of advanced schistosomiasis: a report of 26 cases. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 13:172
Xiong GK, Xion YM, Wan LH (2008) Study of the psychological status and living quality in patients with advanced schistosomiasis. J Pathog Biol 3(S):4–5
Xu H (1998) Analysis of results of ultrasonography in advanced schistosomiasis: a report of 423 cases. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 10:378
Xu HY (2000) Investigation on pathogeny trace of chronic and advanced schistosomiasis patients in Qingpu District of Shanghai. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 18:254
Yan ZJ (2004) Clinical observation on Shenlingbaishusan (a traditional Chinese medicine compound) in treatment of ascites of advanced schistosomiasis: a report of 256 cases. Jiangxi Tradit China Med 35:49
Yi YD (2011) Application of ultrasonography in diagnosis of advanced schistosomiasis. China J Clin Ration Drug Use 4:54
Zeng YL, Fang JQ, Xu SH, Ding W (1993) Animal experiment of Cordyceps sinensis in treatment of schistosomiasis liver fibrosis. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 11:228–229
Zeng LL, Luo DD, Li SL, Liu W, He YW (2003) Expression of IL-2 and TNF-α in the liver and the effect of injection of these cytokines on liver fibrosis in mice infected with Schistosoma japonicum. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 21:150–153
Zhang WC (1987) In vitro inhibitory effect of interferon on simulated granuloma formation by eggs of Schistosoma mansoni. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 5:130–132
Zhang YC (1999) A twenty-year prospective cohort study on correlation among schistosomiasis, HBsAg carrying and hepatic carcinoma. China Pub Hyg 15:397–399
Zhang LH, Cai WM (1991) Preliminary study on T cell subsets and B cells of peripheral blood in advanced schistosomiasis patients. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 3:282–283
Zhang CS, Liu ZZ (1992) Long-term therapeutic effect of splenectomy of advanced schistosomiasis patients with portal hypertension. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 4:60–61
Zhang SF, Zhang YS (1997) Analysis of pathological diagnosis and clinical data of 210 persons clinical diagnosed as advanced schistosomiasis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 9:121
Zhang LH, Cai WM, Liu RH, Chen WZ (1992) Experiment of Cordyceps sinensis in treatment of schistosomiasis liver fibrosis in rabbits. China J Integr Tradit West Med Liver Dis 2:22–24
Zhang XH, Wei RM, Yang X, Wu CZ, Pan BH, Peng KL, Wan GQ, Pan PX, Li QR, Cao ZJ, Yang SC, Jiang ZX (1994) Clinical observation on malotilate therapy for advanced schistosomiasis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 6:265–268
Zhang ZX, Gu JR, Zhu ZY, Li JH, Hu YC, Tao CY (1998) Pathological observation of schistosomiasis hepatic fibrosis coincident with hepatocellular carcinoma. China Oncol 8:88–90
Zhang HX, Cheng CX, Yi JH (2011) Therapeutic effect of capsule Xinganbao (Cordyceps sinensis) on schistosomal hepatocirrhosis. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 23:284
Zhao XG, Zhu JJ, Wang J, Zhao YQ (2006) Correlation investigation between endothelin, serum marker of hepatic fibrosis and advanced schistosomiasis. Trop Dis Parasitol 4:75–77
Zheng QS, Zheng JS (2000) Social medicine and schistosomiasis. Press of Science and Technology of Tianjin, Tianjin, pp 223–230
Zheng N, Jin QS, Yang MJ, Chen Z, Wang HB (2012) Treatment effect of esophageal variceal ligation with different bleeding amount in 107 cases of advanced schistosomiasis. J Trop Med 12:849–950
Zhou ZW, Sun KW, Wu XF, Yi FX (2008) Therapeutic effect of ascites afflux in treatment of obstinate ascites. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 20:309–310
Zhu DH, Li M, Wang YH, Qin B, Zhang YF (1996) A preliminary study of hepatic carcinomas induced by Schistosoma japonicum and diethylnitrosamine in rabbits. Zhongguo Ji Sheng Chong Bing Fang Zhi Za Zhi 9:278–280
Zhu JJ, Huang LX, Chen DL, Zong DM, Zhao YQ, Zhao XG (2007) Study on relationship between liver tissue pathological changes and the fibrosis markers of serum in advanced schistosomiasis japonica. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 19:124–127
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Wei Wu and Aicheng Feng contributed equally to this work.
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Wu, W., Feng, A. & Huang, Y. Research and control of advanced schistosomiasis japonica in China. Parasitol Res 114, 17–27 (2015). https://doi.org/10.1007/s00436-014-4225-x
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DOI: https://doi.org/10.1007/s00436-014-4225-x