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Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae)

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Abstract

In the course of selection of new bioactive compounds from Brazilian flora, the crude MeOH extract from the leaves of Baccharis retusa DC. (Asteraceae) showed potential against Leishmania sp. and Trypanosoma cruzi. Chromatographic fractionation of the dichloromethane phase from MeOH extract yielded great amounts of the bioactive derivative, which was characterized as 5,6,7-trihydroxy-4′-methoxyflavanone. The structure of this compound was established on the basis of spectroscopic data analysis, mainly nuclear magnetic resonance and mass spectrometry.

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Acknowledgments

This work was funded by grants and fellowships from FAPESP (06/57626-5) and Conselho Nacional de Pesquisa e Desenvolvimento (473405/2008-3 and 477422/2009-8). We also thank CNPq for the scientific research award to JHGL, MJPF, and AGT.

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Authors and Affiliations

  1. Departamento de Ciências Exatas e da Terra, Universidade Federal de São Paulo—Campus Diadema, 09972-270, Diadema, São Paulo, Brazil

    Simone S. Grecco, Patricia Sartorelli & Joao H. G. Lago

  2. Laboratório de Toxinologia Aplicada, Serviço de Parasitologia, Divisão de Biologia Médica, Instituto Adolfo Lutz, Avenida Dr. Arnaldo, 351, 8º andar. Cerqueira César, CEP 01246-000, São Paulo, São Paulo, Brazil

    Juliana Q. Reimão & Andre G. Tempone

  3. Centro de Ciências e Humanidades e Centro de Ciências Biológicas e da Saúde, Universidade Presbiteriana Mackenzie, 01302-907, São Paulo, São Paulo, Brazil

    Paulete Romoff, Marcelo J. P. Ferreira & Oriana A. Fávero

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  1. Simone S. Grecco
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  2. Juliana Q. Reimão
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  3. Andre G. Tempone
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  4. Patricia Sartorelli
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  5. Paulete Romoff
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  6. Marcelo J. P. Ferreira
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  7. Oriana A. Fávero
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  8. Joao H. G. Lago
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Corresponding author

Correspondence to Joao H. G. Lago.

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Grecco, S.S., Reimão, J.Q., Tempone, A.G. et al. Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae). Parasitol Res 106, 1245–1248 (2010). https://doi.org/10.1007/s00436-010-1771-8

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  • DOI: https://doi.org/10.1007/s00436-010-1771-8

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