Abstract
Human hantavirus (serotype Puumala) infections are prevalent throughout Europe. The bank vole is the main reservoir of the Puumala virus (PUUV). Between 2001 and 2006, the annual incidences in Germany ranged from 0.1 to 0.5 per 100,000 inhabitants. About half of the cases were reported from the state of Baden-Württemberg (BW) in southwest Germany. In 2007, 1,089 PUUV infections were reported from BW. This reflects an incidence of 10.1:100,000, which is more than 11 times higher than the mean incidence of the previous 6 years. Spatial analysis highlights incidences up to 90:100,000 in the most affected district. The winter season 2006/2007 showed an all time high in reported mean temperature. The previous summer and autumn led to a beech mast year, resulting in favourable feed conditions for bank voles in the winter season 2006/2007. The causes of the observed increase in PUUV infections in 2007 cannot be restricted to known cycles in the bank vole population. Favourable feed conditions, a mild winter and an early onset of spring may have influenced bank vole population size as well as human exposure to infectious rodent excretions. Further epidemiologic studies are necessary to better understand the interaction between environmental factors, occurrence of Puumala virus in bank voles and the risk for human disease.
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Abu Sin M, Stark K, van Treeck U, Dieckmann H, Uphoff H, Hautmann W, Bornhofen B, Jensen E, Pfaff G, Koch J (2007) Risk factors for hantavirus infection in Germany, 2005. Emerg Infect Dis 13(9):1364–1366 (Sep)
Brummer-Korvenkotio M, Henttonen H, Vaheri A (1982) Hemorrhagic fever with renal syndrome in Finland: ecology and virology of nephropathia epidemica. Scand J Infect Dis 36:88–91
Bujalska G (1990) Social system of the bank vole, Clethrionomys glareolus. In: Tamarin R, Ostfeld RS, Pugh SR, Bujalska G (eds) Social systems and population cycles in voles. Birkhäuser, Basel, pp 155–167
Crowcroft NS, Infuso A, Ilef D, Le Guenno B, Desenclos JC, Van Loock F, Clement J (1999) Risk factors for human hantavirus infection: Franco-Belgian collaborative case-control study during 1995–1996 epidemic. BMJ 318:1737–1738
Duchin JS, Koster FT, Peters CJ, Simpson GL, Tempest B, Zaki SR, Ksiazek TG, Rollin PE, Nichol S, Umland ET, Moolenar RL, Reef SE, Nolte KB, Gallaher MM, Butler JC, Breiman RF (1994) Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. N Engl J Med 330:949–955
Engelthaler DM, Mosley DG, Cheek JE, Levy CE, Komatsu KK, Ettestad P, Davis T, Tanda DT, Miller L, Frampton JW, Porter R, Bryan RT (1999) Climatic and environmental patterns associated with hantavirus pulmonary syndrome, Four Corners Region, United States. Emerg Infect Dis 5:87–94
Escutenaire S, Chalon P, Verhagen R, Heyman P, Thomas I, Karelle-Bui L, Avsic-Zupanc T, Lundkvist Å, Plyusnin A, Pastoret PP (2000) Spatial and temporal dynamics of Puumala hantavirus infection in red bank voles (Clethrionomys glareolus) population in Belgium. Virus Res 67:91–107
Faensen D, Claus H, Benzler J, Ammon A, Pfoch T, Breuer T, Krause G (2006) SurvNet@RKI—a multistate electronic reporting system for communicable diseases. Euro Surveill 11(4):100–103
Kimmig P, Silva-Gonzalez R, Backe H, Brockmann S, Oehme R, Ernst E, Mackenstedt U (2001) [Epidemiology of hantaviruses in Baden-Wurttemberg]. Gesundheitswesen 63(2):107–112 (Feb)
Koch J, Brockmann SO, Winter C, Kimmig P, Stark K (2007) Significant increase of hantavirus infections in Germany since the beginning of 2007. Euro Surveill Available at: http://www.eurosurveillance.org/ew/2007/070503.asp#1
Lähdevirta J (1971) Nephropathia epidemica in Finland. A clinical, histological and epidemiological study. Ann Clin Res 3(Supplementum 8):1–154
Niklasson B, Hornfeldt B, Lundkvist Å, Bjorsten S, LeDuc JW (1995) Temporal dynamics of Puumala virus antibody prevalence in voles and of nephropathia epidemica incidence in humans. Am J Trop Med Hyg 53:134–140
Olsson GE, White N, Ahlm C, Elgh F, Verlemyr AC, Juto P, Palo RT (2002) Demographic factors associated with hantavirus infection in bank voles (Clethrionomys glareolus). Emerg Infect Dis 8:924–929
Olsson GE, White N, Hjalten J, Ahlm C (2005) Habitat factors associated with bank voles (Clethrionomys glareolus) and concomitant hantavirus in northern Sweden. Vector Borne Zoonotic Dis Winter 5(4):315–323
Penalba C, Galempoix J-M, Lanoux P (2001) Epidemiology of hantavirus infections in France. Médicine et Maladies Infectieuses 31:272–284
Pilaski J, Ellerich C, Kreutzer T, Lang A, Benik W, Pohl-Koppe A, Bode L, Vanek E, Autenrieth IB, Bigos K (1991) Haemorrhagic fever with renal syndrome in Germany. Lancet 337:111
Plyusnin A, Morzunov SP (2001) Virus evolution and genetic diversity of Hantaviruses and their rodent hosts. In: Schmaljohn CS, Nichol ST (eds) Hantaviruses. Current topics in microbiology and immunology. Springer, Berlin, pp 47–75
Rieger MA, Nübling M, Hofmann F (2005) [Occupational risk for hantavirus infection in farmers]. Schriftenreihe der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin fb1036. Edts.: Bundesanstalt für Arbeitsschutz und Arbeitsmedizin, Bonn. ISBN 3-86509-253-5
RKI (2006) Hantavirus-Erkrankungen: Niedersächsische Fall-Kontroll-Studie zum gehäuften Auftreten in den Jahren 2004 und 2005. Epidemiologisches Bulletin 40:15–16
Rose AM, Vapalahti O, Lyytikäinen O, Nuorti P (2003) Patterns of Puumala virus infection in Finland. Euro Surveill 8(1):9–13 (Jan)
Sauvage F, Penalba C, Vuillaume P, Boue F, Coudrier D, Pontier D, Artois M (2002) Puumala hantavirus infection in humans and in the reservoir host, Ardennes region, France. Emerg Infect Dis 8:1509–1511
Sauvage F, Langlais M, Pontier D (2007) Predicting the emergence of human hantavirus disease using a combination of viral dynamics and rodent demographic patterns. Epidemiol Infect 135:46–56
Siffczyk C (2005) Epidemiologische Untersuchung eines gehäuften Auftretens von Hantavirus-Infektionen. Magisterarbeit Medizinische Hochschule Hannover
Ulrich R, Meisel H, Schütt M, Schmidt J, Kunz A, Klempa B, Niedrig M, Kimmig P, Pauli G, Krüger DH, Koch J (2004) Verbreitung von Hantavirusinfektionen in Deutschland. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:661–670
Van Loock F, Thomas I, Clement J, Ghoos S, Colson P (1999) A case-control study after a hantavirus infection outbreak in the south of Belgium: who is at risk? Clin Infect Dis 28(4):834–839 (Apr)
Vapalahti O, Mustonen J, Lundkvist A, Henttonen H, Plyusnin A, Vaheri A (2003) Hantavirus infections in Europe. Lancet Infect Dis 3(10):653–661 (Oct)
Yates TL, Mills JN, Parmenter RR, Ksiazek TG, Paramenter CA, Vandem Castle JR, Calisher CH, Nichols ST, Abbott KD, Young JC, Morrison ML, Beaty BJ, Dunnum JL, Baker RJ, Salazar-Bravo J, Peters CJ (2002) The ecology and evolutionary history of an emergent disease: hantavirus pulmonary syndrome. Bioscience 52:989–998
Zöller L, Faulde M, Meisel H, Ruh B, Kimmig P, Schelling U, Zeier M, Kulzer P, Becker C, Roggendorf M, Bautz EKF, Krüger DH, Darai G (1995) Seroprevalence of hantavirus antibodies in Germany as determined by a new recombinant enzyme immunoassay. Eur J Clin Microbiol Infect Dis 14:303–315
Acknowledgments
We thank all local health offices in Baden-Württemberg for their enormous work on the notification of all hantavirus cases in 2007. We thank Gerald Kändler and Johannes Breidenbach (Forstliche Versuchs-und Forschungsanstalt Baden-Württemberg, FVA) for providing data from the forest inventory and Thomas Ebinger (Staatsklenge Nagold) for the beech mast data.
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Piechotowski, I., Brockmann, S.O., Schwarz, C. et al. Emergence of hantavirus in South Germany: rodents, climate and human infections. Parasitol Res 103 (Suppl 1), 131–137 (2008). https://doi.org/10.1007/s00436-008-1055-8
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DOI: https://doi.org/10.1007/s00436-008-1055-8