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In vitro activity of perifosine: a novel alkylphospholipid against the promastigote stage of Leishmania species

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Abstract

Perifosine is a novel alkylphospholipid. Perifosine has displayed significant antiproliferative activity in vitro and in vivo in several human tumor model systems and has recently entered phase II clinical trials. Other alkylphospholipids have been previously used as antileishmanial agents, and miltefosine (Impavido) is now established as the first oral drug for the treatment of visceral and cutaneous leishmaniasis. Perifosine showed the higher activity against all tested strains. This study demonstrates for, the first time, an in vitro activity of perifosine against different species of Leishmania in the promastigote stage.

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References

  • Croft SL, Barrett MP, Urbina JA (2005) Chemotherapy of trypanosomiases and leishmaniasis. Trends Parasitol 21:508–512

    Article  PubMed  CAS  Google Scholar 

  • Escobar P, Matu S, Marques C, Croft SL (2002) Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH (3) (edelfosine) and amphotericin B. Acta Trop 81:151–157

    Article  PubMed  CAS  Google Scholar 

  • Knowling M, Blackstein M, Tozer R, Bramwell V, Dancey J, Dore N, Matthews S, Eisenhauer EA (2006) Phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: a National Cancer Institute of Canada Clinical Trials Group trial. Invest New Drugs 24:435–439

    Article  PubMed  CAS  Google Scholar 

  • Piñero J, Temporal RM, Silva-Goncalves AJ, Jimenez IA, Bazzocchi IL, Oliva A, Perera A, Leon LL, Valladares B (2006) New administration model of trans-chalcone biodegradable polymers for the treatment of experimental leishmaniasis. Acta Trop 98:59–65

    Article  PubMed  Google Scholar 

  • Santa-Rita RM, Henriques-Pons A, Barbosa HS, de Castro SL (2004) Effect of the lysophospholipid analogues edelfosine, ilmofosine and miltefosine against Leishmania amazonensis. J Antimicrob Chemother 54:704–710

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

This work was supported by a Redes Temáticas de Investigación Cooperativa, Project # C0304 titled Enfermedades Tropicales: De la Genómica al Control (FIS), by a FIS Project # PI052707. MG Cabrera-Serra is granted by a Project from Fundación Canaria de Investigación y Ciencia (FUNCIS) # PI89/05.

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Authors and Affiliations

  1. Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, University of La Laguna, Avda. Astrofísico Fco. Sánchez, S/N 38203 La Laguna, Canary Islands, Spain

    María Gabriela Cabrera-Serra, Jacob Lorenzo-Morales, Marialina Romero, Basilio Valladares & José E. Piñero

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  1. María Gabriela Cabrera-Serra
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  2. Jacob Lorenzo-Morales
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  3. Marialina Romero
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  4. Basilio Valladares
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  5. José E. Piñero
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Correspondence to José E. Piñero.

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Cabrera-Serra, M.G., Lorenzo-Morales, J., Romero, M. et al. In vitro activity of perifosine: a novel alkylphospholipid against the promastigote stage of Leishmania species. Parasitol Res 100, 1155–1157 (2007). https://doi.org/10.1007/s00436-006-0408-4

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  • DOI: https://doi.org/10.1007/s00436-006-0408-4

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