Abstract
Species of the Viola genus, used in traditional medicines for the treatment of parasites, were collected and petroleum ether extract was obtained by sonication. The antiplasmodial activity of petroleum ether extracts was evaluated in vitro against the chloroquine-resistant FcB1 strain of Plasmodium falciparum. Bioactivity-guided fractionation of the petroleum ether extracts of the whole plants of Viola verecunda has led to the isolation of epi-oleanolic acid, a triterpenoid, displaying high antiplasmodial activity (IC50 0.18 μg/ml). This is the first report of the isolation and antiplasmodial activity of epi-oleanolic acid from this species.
References
Akhtar N, Malik A (1993) Oleanane type triterpenes from Plumeria rubra Phytochemistry 32:1523–1525
Amer A, Mehlhorn H (2006) Repellency effect of forty-one essential oils against Aedes, Anopheles, and Culex mosquitoes. Parasitol Res 99(4):478–490
Carnat AP, Carnet A, Fraisse D (1998) Violarvensin, a new flavone di-C-glycoside from Viola arvensis. J Nat Prod 61:272–274
Clarkson C, Maharaj VJ, Crouch NR (2004) In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa. J Ethnopharmacol 92:177–191
Jung MJ, Yoo YC, Lee KB, Kim JB, Song KS (2004) Isolation of epi-oleanolic acid from Korean istletoe and its apoptosis-inducing activity in tumor cells. Arch Pharm Res 27:840–844
Kwon HC, Lee KR, Zee OP (1997) Cytotoxic constituents of Pilea mongolica. Arch Pharm Res 20:180–183
Lee YN (1996) Flora of Korea, Kyohak-Sa, Seoul, Korea, p.126
Lindholm P, Goransson U, Johansson S (2002) Cyclotides: a novel type of cytotoxic agents. Mol Cancer Ther 1:365–369
Makler MT, Ries JM, Williams JA (1993) Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity. Am J Trop Med Hyg 48:739–741
Petelot A (1952) Les plantes m´edicinales du Cambodge, du Laos et du Vietnam. In: Tome I (ed) Centre de Recherches Scientifiques et Techniques, I.D.E.O., Saigon
Schuele S, Lederman RJ (2004) Long-term outcome of focal dystonia in string instrumentalists. Mov Disord 19:43–48
Trager W, Jensen JB (1976) Human malaria parasite in continuous culture. Science 193:673–675
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Moon, HI., Jung, JC. & Lee, J. Antiplasmodial activity of triterpenoid isolated from whole plants of Viola genus from South Korea. Parasitol Res 100, 641–644 (2007). https://doi.org/10.1007/s00436-006-0279-8
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DOI: https://doi.org/10.1007/s00436-006-0279-8