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A multi-institutional study of clinicopathological features and molecular epidemiology of epidermal growth factor receptor mutations in lung cancer patients living with human immunodeficiency virus infection

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Purpose

Lung cancer has become a crucial problem among individuals living with the human immunodeficiency virus (HIV) and causes high mortality in Western countries. Japan has an increasing number of newly infected HIV patients, and lung cancer is becoming a theme in this population. However, clinical factors of this particular population in East Asian are unclear given the identification of ethnic differences in lung cancer in the general population.

Methods

From 1986 to 2013, a retrospective nationwide study involving Japanese patients living with HIV and diagnosed with lung cancer was undertaken.

Results

Forty-three lung cancer patients with HIV were identified (median age, 60.0 years; males, 97.7 %; early-stage cancer, 37.2 %; metastatic cancer, 34.9 %), 41 (95.3 %) of whom developed lung cancer in the antiretroviral era. The median CD4-positive T-cell count was 326 cells/µL. Adenocarcinoma was the most frequent histology (55.8 %), followed by squamous cell carcinoma (27.9 %). Epidermal growth factor receptor (EGFR) status was examined in 14 patients; five (35.7 %) had EGFR mutations. The median overall survival time was 25.1 months for all stages and 7.9 months for advanced-stage cancer. Using univariate analysis, the only favorable prognostic factor for overall survival was cancer stage (p = 0.02).

Conclusions

The incidence of lung cancer among HIV patients in Japan has been increasing in the past decade. The present Japanese cohort showed similar EGFR mutation status similar to that of general population. The ethnic differences known in the general population were seen even in the population living with HIV, implying distinct clinical characteristics and outcomes from those reported in Western countries.

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Acknowledgments

This study was supported by a Health and Labour Sciences Research Grant from the Japanese Ministry of Health, Labour and Welfare (Grant Number: H25-AIDS-I-002). The authors thank Makoto Saito, the Senior Biostatistician at the Office for Clinical Research Support in Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, for statistical advice, and the authors would like to thank Enago (www.enago.jp) for the English language review.

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethics standard

This study was approved by the ethics committee of the Tokyo Metropolitan Cancer and Infectious diseases Center, Komagome Hospital (Tokyo, Japan), and conducted in accordance with the Declaration of Helsinki.

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Authors and Affiliations

  1. Departments of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo, Tokyo, 113-8677, Japan

    Yusuke Okuma

  2. Departments of Infectious Disease, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Tokyo, Japan

    Atsushi Ajisawa

  3. AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan

    Junko Tanuma

  4. Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan

    Yuichiro Takeda

  5. Department of Infectious Diseases, National Hospital Organization Osaka Medical Center, Osaka, Japan

    Hiroshi Kamiryo & Tomoko Uehira

  6. Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan

    Yuki Kojima & Hirokazu Nagai

  7. Department of Laboratory Medicine, Tokyo Medical University, Tokyo, Japan

    Mihoko Yotsumoto

  8. Department of Respiratory Medicine, Tokyo Medical University, Tokyo, Japan

    Yasuhiro Setoguchi

  9. Center for AIDS Research, Kumamoto University, Kumamoto, Japan

    Seiji Okada

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  1. Yusuke Okuma
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Correspondence to Yusuke Okuma.

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Okuma, Y., Tanuma, J., Kamiryo, H. et al. A multi-institutional study of clinicopathological features and molecular epidemiology of epidermal growth factor receptor mutations in lung cancer patients living with human immunodeficiency virus infection. J Cancer Res Clin Oncol 141, 1669–1678 (2015). https://doi.org/10.1007/s00432-015-1956-8

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