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Final results of a phase II trial for stereotactic body radiation therapy for patients with inoperable liver metastases from colorectal cancer

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Purpose

To evaluate the feasibility and efficacy of stereotactic body radiation therapy (SBRT) in the treatment of colorectal liver metastases.

Methods

Forty-two patients with inoperable colorectal liver metastases not amenable to radiofrequency ablation (RFA) were treated with SBRT for a total number of 52 lesions. All patients received a total dose of 75 Gy in 3 consecutive fractions. Mean size of the lesions was 3.5 cm (range 1.1–5.4). Toxicity was classified according to the Common Toxicity Criteria version 3.0.

Results

Median follow-up was 24 (range 4–47) months. The progression in field was observed in 5 lesions. Twenty-four months actuarial local control (LC) rate was 91 %. Median overall survival (OS) was 29.2 ± 3.7 months. Actuarial OS rate at 24 months was 65 %. Median progression-free survival was 12.0 ± 4.2 months; 24 months actuarial rate was 35 %. No patients experienced radiation-induced liver disease or grade ≥3 toxicity.

Conclusions

SBRT represents a feasible alternative for the treatment of colorectal liver metastases not amenable to surgery or other ablative treatments in selected patients, showing optimal LC and promising survival rate.

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Conflict of interest

L. Cozzi acts as Scientific Advisor to Varian Medical Systems and is Head of Research and Technological Development to IOSI, Bellinzona. All other co-authors have no conflicts of interests. No other conflicts exist for all other authors.

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Authors and Affiliations

  1. Radiotherapy and Radiosurgery, Oncology, Liver Surgery Departments, Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, Milano, Italy

    Marta Scorsetti, Tiziana Comito, Angelo Tozzi, Pierina Navarria, Elena Clerici, Pietro Mancosu, Giacomo Reggiori, Lorenza Rimassa, Guido Torzilli, Stefano Tomatis & Armando Santoro

  2. Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

    Antonella Fogliata & Luca Cozzi

Authors
  1. Marta Scorsetti
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  2. Tiziana Comito
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  3. Angelo Tozzi
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  4. Pierina Navarria
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  5. Antonella Fogliata
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  6. Elena Clerici
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  9. Lorenza Rimassa
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  10. Guido Torzilli
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  12. Armando Santoro
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  13. Luca Cozzi
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Correspondence to Marta Scorsetti.

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Scorsetti, M., Comito, T., Tozzi, A. et al. Final results of a phase II trial for stereotactic body radiation therapy for patients with inoperable liver metastases from colorectal cancer. J Cancer Res Clin Oncol 141, 543–553 (2015). https://doi.org/10.1007/s00432-014-1833-x

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  • DOI: https://doi.org/10.1007/s00432-014-1833-x

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