Original Paper

Journal of Cancer Research and Clinical Oncology

, Volume 137, Issue 9, pp 1301-1308

Nomogram predicting clinical outcomes in breast cancer patients treated with neoadjuvant chemotherapy

  • Bhumsuk KeamAffiliated withDepartment of Internal Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National University College of Medicine
  • , Seock-Ah ImAffiliated withDepartment of Internal Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National University College of Medicine Email author 
  • , Sohee ParkAffiliated withCancer Biostatistics Branch, Research Institute, National Cancer Center
  • , Byung-Ho NamAffiliated withCancer Biostatistics Branch, Research Institute, National Cancer Center
  • , Sae-Won HanAffiliated withDepartment of Internal Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National University College of Medicine
  • , Do-Youn OhAffiliated withDepartment of Internal Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National University College of Medicine
  • , Jee Hyun KimAffiliated withDepartment of Internal Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University Bundang Hospital
  • , Se-Hoon LeeAffiliated withDepartment of Internal Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National University College of Medicine
  • , Wonshik HanAffiliated withCancer Research Institute, Seoul National University College of MedicineDepartment of Surgery, Seoul National University College of Medicine
    • , Dong-Wan KimAffiliated withDepartment of Internal Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National University College of Medicine
    • , Tae-You KimAffiliated withDepartment of Internal Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National University College of Medicine
    • , In Ae ParkAffiliated withCancer Research Institute, Seoul National University College of MedicineDepartment of Pathology, Seoul National University College of Medicine
    • , Dong-Young NohAffiliated withCancer Research Institute, Seoul National University College of MedicineDepartment of Surgery, Seoul National University College of Medicine
    • , Dae Seog HeoAffiliated withDepartment of Internal Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National University College of Medicine
    • , Yung-Jue BangAffiliated withDepartment of Internal Medicine, Seoul National University College of MedicineCancer Research Institute, Seoul National University College of Medicine

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Purpose

The aim of this study was to combine clinical pathologic variables that are associated with pathologic completer response (pCR) and relapse-free survival (RFS) after neoadjuvant chemotherapy into prediction nomograms.

Methods

A total of 370 stage II or III breast cancer patients who received neoadjuvant docetaxel/doxorubicin chemotherapy were enrolled in this study. We developed the nomograms using logistic regression model for pCR and Cox proportional hazard regression model for RFS.

Results

The nomogram for pCR based on initial tumor size, estrogen receptor (ER), human epidermal growth factor receptor 2, and Ki67 had good discrimination performance (AUROC = 0.830). Multivariate Cox model identified age less than 35, initial clinical stage, pathologic stage, ER, Ki67 as prognostic factors, and the nomogram for RFS was developed based on these covariates. The concordance index for the second nomogram was 0.781, and calibration was also good.

Conclusions

We developed nomograms based on clinical and pathologic characteristics to predict the probability of pCR and RFS for patients receiving neoadjuvant docetaxel/doxorubicin chemotherapy.

Keywords

Nomogram Breast cancer Neoadjuvant chemotherapy Prediction