European Journal of Pediatrics

, Volume 172, Issue 7, pp 987–989

Pseudothrombocytopenia in a neonate due to mother?

Authors

    • Department of PaediatricsMedical Center Alkmaar
    • Department of PaediatricsJeroen Bosch Hospital
  • B. Boersma
    • Department of PaediatricsMedical Center Alkmaar
  • M. Schoorl
    • Department of Clinical Chemistry, Haematology and ImmunologyMedical Center Alkmaar
  • L. Porcelijn
    • Sanquin Diagnostic Services
  • P. C. M. Bartels
    • Department of Clinical Chemistry, Haematology and ImmunologyMedical Center Alkmaar
Case Report

DOI: 10.1007/s00431-012-1892-4

Cite this article as:
Korterink, J.J., Boersma, B., Schoorl, M. et al. Eur J Pediatr (2013) 172: 987. doi:10.1007/s00431-012-1892-4

Abstract

Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a false low platelet count reported by an automated haematology analyzer due to in vitro aggregation of platelets. This aggregation is due to the interaction between antibodies and EDTA-dependent crypt antigens on platelets. We observed a new born child whose mother was diagnosed with transient PTCP due to transplacental transmission of maternal immunoglobulin G antibodies during pregnancy. Conclusion: Although maternal–neonatal PTCP is rare, it is important to consider this phenomenon as a cause of trombocytopenia, as it can result in unnecessary diagnostic workup and treatment.

Keywords

PseudothrombocytopeniaEDTA-dependent PTCPNeonateEDTA

Copyright information

© Springer-Verlag Berlin Heidelberg 2012