Pseudothrombocytopenia in a neonate due to mother?
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Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a false low platelet count reported by an automated haematology analyzer due to in vitro aggregation of platelets. This aggregation is due to the interaction between antibodies and EDTA-dependent crypt antigens on platelets. We observed a new born child whose mother was diagnosed with transient PTCP due to transplacental transmission of maternal immunoglobulin G antibodies during pregnancy. Conclusion: Although maternal–neonatal PTCP is rare, it is important to consider this phenomenon as a cause of trombocytopenia, as it can result in unnecessary diagnostic workup and treatment.
- Pseudothrombocytopenia in a neonate due to mother?
European Journal of Pediatrics
Volume 172, Issue 7 , pp 987-989
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- Springer Berlin Heidelberg
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- EDTA-dependent PTCP
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- Author Affiliations
- 1. Department of Paediatrics, Medical Center Alkmaar, Alkmaar, Netherlands
- 4. Department of Paediatrics, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ, Hertogenbosch, The Netherlands
- 2. Department of Clinical Chemistry, Haematology and Immunology, Medical Center Alkmaar, Alkmaar, The Netherlands
- 3. Sanquin Diagnostic Services, Amsterdam, The Netherlands