Case Report

European Journal of Pediatrics

, Volume 172, Issue 7, pp 987-989

Pseudothrombocytopenia in a neonate due to mother?

  • J. J. KorterinkAffiliated withDepartment of Paediatrics, Medical Center AlkmaarDepartment of Paediatrics, Jeroen Bosch Hospital Email author 
  • , B. BoersmaAffiliated withDepartment of Paediatrics, Medical Center Alkmaar
  • , M. SchoorlAffiliated withDepartment of Clinical Chemistry, Haematology and Immunology, Medical Center Alkmaar
  • , L. PorcelijnAffiliated withSanquin Diagnostic Services
  • , P. C. M. BartelsAffiliated withDepartment of Clinical Chemistry, Haematology and Immunology, Medical Center Alkmaar

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Abstract

Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a false low platelet count reported by an automated haematology analyzer due to in vitro aggregation of platelets. This aggregation is due to the interaction between antibodies and EDTA-dependent crypt antigens on platelets. We observed a new born child whose mother was diagnosed with transient PTCP due to transplacental transmission of maternal immunoglobulin G antibodies during pregnancy. Conclusion: Although maternal–neonatal PTCP is rare, it is important to consider this phenomenon as a cause of trombocytopenia, as it can result in unnecessary diagnostic workup and treatment.

Keywords

Pseudothrombocytopenia EDTA-dependent PTCP Neonate EDTA