Pseudothrombocytopenia in a neonate due to mother?
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- Korterink, J.J., Boersma, B., Schoorl, M. et al. Eur J Pediatr (2013) 172: 987. doi:10.1007/s00431-012-1892-4
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Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a false low platelet count reported by an automated haematology analyzer due to in vitro aggregation of platelets. This aggregation is due to the interaction between antibodies and EDTA-dependent crypt antigens on platelets. We observed a new born child whose mother was diagnosed with transient PTCP due to transplacental transmission of maternal immunoglobulin G antibodies during pregnancy. Conclusion: Although maternal–neonatal PTCP is rare, it is important to consider this phenomenon as a cause of trombocytopenia, as it can result in unnecessary diagnostic workup and treatment.