European Journal of Pediatrics

, 168:1181

Tetracycline-resistant Escherichia coli strains are inherited from parents and persist in the infant’s intestines in the absence of selective pressure

Authors

    • Department of PediatricsMedical University Innsbruck
  • Katharina Grif
    • Department of Hygiene, Microbiology and Social MedicineMedical University Innsbruck
  • Cornelia Decristoforo
    • Department of Hygiene, Microbiology and Social MedicineMedical University Innsbruck
  • Reinhard Würzner
    • Department of Hygiene, Microbiology and Social MedicineMedical University Innsbruck
  • Ursula Kiechl-Kohlendorfer
    • Department of PediatricsMedical University Innsbruck
  • Andrea Brunner
    • Department of PathologyMedical University Innsbruck
  • Lothar Bernd Zimmerhackl
    • Department of PediatricsMedical University Innsbruck
  • Dorothea Orth
    • Department of Hygiene, Microbiology and Social MedicineMedical University Innsbruck
Original Paper

DOI: 10.1007/s00431-008-0901-0

Cite this article as:
Prelog, M., Grif, K., Decristoforo, C. et al. Eur J Pediatr (2009) 168: 1181. doi:10.1007/s00431-008-0901-0
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Abstract

The study investigated tetracycline (TC), ampicillin (AMP), cefazolin (CEF), and trimethoprim (TMP) resistance in Escherichia coli (E. coli) in the feces of 21 infants up to 6 months of age and in their parents in the absence of selective antimicrobial pressure. Clonality of strains was assessed by pulsed-field gel electrophoresis. Three infants had resistant E. coli strains in their feces identical to the mothers’ from week 1 on, which persisted over weeks. From week 2 on, in another four infants, persisting resistant E. coli were found, two of them identical to the mothers’. All of these persisting E. coli strains (except one family) showed at least resistance to TC. In infants, resistant E. coli strains inherited from their mothers tended to persist over months. Therefore, the persistence of resistant E. coli and their possible capacity to cause symptomatic infection or transfer its resistance genes to other bacteria deserves more attention.

Keywords

Escherichia coliResistanceTetracyclineAmpicillinCefazolinTrimethoprimColonization

Copyright information

© Springer-Verlag 2008