European Journal of Pediatrics

, 168:1181

Tetracycline-resistant Escherichia coli strains are inherited from parents and persist in the infant’s intestines in the absence of selective pressure

  • Martina Prelog
  • Katharina Grif
  • Cornelia Decristoforo
  • Reinhard Würzner
  • Ursula Kiechl-Kohlendorfer
  • Andrea Brunner
  • Lothar Bernd Zimmerhackl
  • Dorothea Orth
Original Paper

DOI: 10.1007/s00431-008-0901-0

Cite this article as:
Prelog, M., Grif, K., Decristoforo, C. et al. Eur J Pediatr (2009) 168: 1181. doi:10.1007/s00431-008-0901-0

Abstract

The study investigated tetracycline (TC), ampicillin (AMP), cefazolin (CEF), and trimethoprim (TMP) resistance in Escherichia coli (E. coli) in the feces of 21 infants up to 6 months of age and in their parents in the absence of selective antimicrobial pressure. Clonality of strains was assessed by pulsed-field gel electrophoresis. Three infants had resistant E. coli strains in their feces identical to the mothers’ from week 1 on, which persisted over weeks. From week 2 on, in another four infants, persisting resistant E. coli were found, two of them identical to the mothers’. All of these persisting E. coli strains (except one family) showed at least resistance to TC. In infants, resistant E. coli strains inherited from their mothers tended to persist over months. Therefore, the persistence of resistant E. coli and their possible capacity to cause symptomatic infection or transfer its resistance genes to other bacteria deserves more attention.

Keywords

Escherichia coliResistanceTetracyclineAmpicillinCefazolinTrimethoprimColonization

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Martina Prelog
    • 1
  • Katharina Grif
    • 2
  • Cornelia Decristoforo
    • 2
  • Reinhard Würzner
    • 2
  • Ursula Kiechl-Kohlendorfer
    • 1
  • Andrea Brunner
    • 3
  • Lothar Bernd Zimmerhackl
    • 1
  • Dorothea Orth
    • 2
  1. 1.Department of PediatricsMedical University InnsbruckInnsbruckAustria
  2. 2.Department of Hygiene, Microbiology and Social MedicineMedical University InnsbruckInnsbruckAustria
  3. 3.Department of PathologyMedical University InnsbruckInnsbruckAustria