European Journal of Pediatrics

, Volume 168, Issue 5, pp 625–627

Effectiveness of pamidronate in severe neonatal hypercalcemia caused by subcutaneous fat necrosis: a case report


  • G. Lombardi
    • Neonatal Intensive Care Unit
    • Neonatal Intensive Care Unit
  • L. Bollani
    • Neonatal Intensive Care Unit
  • C. Del Forno
    • Institute of DermatologyUniversity of Pavia
  • M. Stronati
    • Neonatal Intensive Care Unit
Short Report

DOI: 10.1007/s00431-008-0797-8

Cite this article as:
Lombardi, G., Cabano, R., Bollani, L. et al. Eur J Pediatr (2009) 168: 625. doi:10.1007/s00431-008-0797-8


Subcutaneous fat necrosis of the newborn (SCFN) is a panniculitis that develops in fatty areas during the first weeks of life after foetal distress or perinatal complications. Prognosis is generally good with complete regression, but it can be complicated by metabolic abnormalities like hypoglycemia, hypertriglyceridemia, thrombocytopenia, and also potentially life-threatening hypercalcemia. We report a case of severe hypercalcemia complicating SCFN in a newborn who was treated with hyperhydration, furosemide, prednisone, and pamidronate.


HypercalcemiaNewbornPamidronateSubcutaneous fat necrosisTherapy



Subcutaneous fat necrosis of the newborn


Sclerema neonatorum

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© Springer-Verlag 2008