Short Report

European Journal of Pediatrics

, Volume 168, Issue 5, pp 625-627

First online:

Effectiveness of pamidronate in severe neonatal hypercalcemia caused by subcutaneous fat necrosis: a case report

  • G. LombardiAffiliated withNeonatal Intensive Care Unit
  • , R. CabanoAffiliated withNeonatal Intensive Care Unit Email author 
  • , L. BollaniAffiliated withNeonatal Intensive Care Unit
  • , C. Del FornoAffiliated withInstitute of Dermatology, University of Pavia
  • , M. StronatiAffiliated withNeonatal Intensive Care Unit

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Subcutaneous fat necrosis of the newborn (SCFN) is a panniculitis that develops in fatty areas during the first weeks of life after foetal distress or perinatal complications. Prognosis is generally good with complete regression, but it can be complicated by metabolic abnormalities like hypoglycemia, hypertriglyceridemia, thrombocytopenia, and also potentially life-threatening hypercalcemia. We report a case of severe hypercalcemia complicating SCFN in a newborn who was treated with hyperhydration, furosemide, prednisone, and pamidronate.


Hypercalcemia Newborn Pamidronate Subcutaneous fat necrosis Therapy