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Anosmin-1 over-expression regulates oligodendrocyte precursor cell proliferation, migration and myelin sheath thickness

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An Erratum to this article was published on 13 March 2015

Abstract

During development of the central nervous system, anosmin-1 (A1) works as a chemotropic cue contributing to axonal outgrowth and collateralization, as well as modulating the migration of different cell types, fibroblast growth factor receptor 1 (FGFR1) being the main receptor involved in all these events. To further understand the role of A1 during development, we have analysed the over-expression of human A1 in a transgenic mouse line. Compared with control mice during development and in early adulthood, A1 over-expressing transgenic mice showed an enhanced oligodendrocyte precursor cell (OPC) proliferation and a higher number of OPCs in the subventricular zone and in the corpus callosum (CC). The migratory capacity of OPCs from the transgenic mice is increased in vitro due to a higher basal activation of ERK1/2 mediated through FGFR1 and they also produced more myelin basic protein (MBP). In vivo, the over-expression of A1 resulted in an elevated number of mature oligodendrocytes with higher levels of MBP mRNA and protein, as well as increased levels of activation of the ERK1/2 proteins, while electron microscopy revealed thicker myelin sheaths around the axons of the CC in adulthood. Also in the mature CC, the nodes of Ranvier were significantly longer and the conduction velocity of the nerve impulse in vivo was significantly increased in the CC of A1 over-expressing transgenic mice. Altogether, these data confirmed the involvement of A1 in oligodendrogliogenesis and its relevance for myelination.

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Acknowledgments

We are grateful to Dr. José Ángel Rodríguez Alfaro and Dr. Javier Mazarío for their help with the confocal imaging, to Isabel Machín, Rafael Lebrón, Iris Sánchez, Jacinto Sarmentero, and José María González for their technical assistance, and to Mr. Roger Churchill for his editorial help. We are also grateful to Dr. Diego García González for the critical reading of the manuscript. This work was supported by grants from the Spanish Ministerio de Economía y Competitividad-MINECO (Grant Numbers SAF2009-07842, SAF2012-40023, RD07-0060-2007 and RD12-0032-12 Red Española de Esclerosis Múltple) and the “Fundación Eugenio Rodríguez Pascual” to FdC; the Fundación para la Investigación Socio-sanitaria de Castilla La-Mancha FISCAM (Grant Number PI2007-66 to FdC and PI2009-29 to PFE); from the Spanish MINECO (Grant Numbers BFU2008-00899 and BFU2008-03390) and the Junta de Andalucía (Grant Numbers BIO-122, CVI-02487 and P07-CVI-02686) to JMDG and AGM; and from the Spanish MINECO (Grant Number BFU-2009-08404) to RL. VMB was hired under FISCAM (MOV2007-JI/19), SAF2009-07842 and RD07-0060-2007; PFE was hired by the Servicio de Salud de Castilla La-Mancha (SESCAM, Gobierno de Castilla-La Mancha) and under grant ADE10-0010 from MINECO to FdC. FdC is a CSIC Staff Scientist on leave of absence and currently hired by SESCAM.

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  1. Verónica Murcia-Belmonte

    Present address: Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Campus San Juan de Alicante, 03550, Alicante, Spain

Authors and Affiliations

  1. Grupo de Neurobiología del Desarrollo-GNDe, Hospital Nacional de Parapléjicos, Finca La Peraleda, s/n, 45071, Toledo, Spain

    Verónica Murcia-Belmonte, Pedro F. Esteban & Fernando de Castro

  2. Departamento de Ciencias Médicas, CRIB-Facultad de Medicina, Universidad de Castilla-La Mancha, C/Almansa 14, 02006, Albacete, Spain

    José Martínez-Hernández & Rafael Luján

  3. División de Neurociencias, Universidad Pablo de Olavide, Ctra. De Utrera, Km.1, 41013, Seville, Spain

    Agnès Gruart & José María Delgado-García

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  1. Verónica Murcia-Belmonte
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  2. Pedro F. Esteban
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  3. José Martínez-Hernández
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  7. Fernando de Castro
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Correspondence to Fernando de Castro.

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We acknowledge Pedro F. Esteban and Fernando de Castro for their joint supervision.

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Murcia-Belmonte, V., Esteban, P.F., Martínez-Hernández, J. et al. Anosmin-1 over-expression regulates oligodendrocyte precursor cell proliferation, migration and myelin sheath thickness. Brain Struct Funct 221, 1365–1385 (2016). https://doi.org/10.1007/s00429-014-0977-4

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  • DOI: https://doi.org/10.1007/s00429-014-0977-4

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