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Pattern of recurrent disease in major salivary gland adenocystic carcinoma

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Abstract

This study aims to evaluate the long-term outcome of major salivary gland adenocystic carcinoma (ACC). This is a retrospective review of 54 cases of ACC during a 35-year period from 1974 to 2009 at the Helsinki University Central Hospital, Helsinki, Finland. Medical records and histological samples were reviewed. All patients had a minimum follow-up time of 5 years or until death. Most of the tumours occurred in the parotid gland (n = 30, 56 %) followed by submandibular gland (n = 22, 41 %) and sublingual gland (n = 2, 4 %). Fifty-two patients (96 %) were treated with curative intent. All of these patients except one were primarily treated with surgery, and 29 patients (54 %) also received postoperative radiotherapy for their primary tumour. Two patients (4 %) received palliative radiotherapy. For those treated with curative intent, 32 patients (62 %) had disease recurrence. Twenty-four patients (75 %) had their first disease recurrence within 5 years and eight patients (25 %) later than 5 years. The difference in the length of recurrence-free time interval (<5 vs. >5 years) had a significant impact on 5-year overall survival (OS) and disease-specific survival (DSS). The OS, DSS and disease-free survival (DFS) across stages I–IV varied between 46–100, 50–100 and 46–100 %, respectively. Age over 45 years, T stage, and presence of neck metastases had a significant negative prognostic effect. More than half of the patients had recurrent disease. An extended follow-up for these patients seems feasible as most of the distant metastases were detected within a 10-year period.

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Acknowledgments

This study was supported by the Helsinki University Central Hospital Research Fund and the Sigrid Jusélius Foundation.

Conflict of interests

None declared.

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Authors and Affiliations

  1. Department of Otorhinolaryngology—Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, HUCH, P.O.Box 220, FI-00029, Helsinki, Finland

    Karoliina Hirvonen, Leif Bäck & Antti A. Mäkitie

  2. Department of Oncology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

    Kauko Saarilahti

  3. Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

    Ilmo Leivo & Jaana Hagström

  4. Department of Pathology, University of Turku, Turku, Finland

    Ilmo Leivo

  5. Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

    Antti A. Mäkitie

Authors
  1. Karoliina Hirvonen
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  2. Leif Bäck
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  3. Kauko Saarilahti
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  4. Ilmo Leivo
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  5. Jaana Hagström
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  6. Antti A. Mäkitie
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Correspondence to Karoliina Hirvonen.

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Hirvonen, K., Bäck, L., Saarilahti, K. et al. Pattern of recurrent disease in major salivary gland adenocystic carcinoma. Virchows Arch 467, 19–25 (2015). https://doi.org/10.1007/s00428-015-1760-5

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  • DOI: https://doi.org/10.1007/s00428-015-1760-5

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