Skip to main content

Advertisement

SpringerLink
Log in

Primary tumor size predicts pathologic findings in the retroperitoneal lymph nodes in patients with paratesticular rhabdomyosarcoma

  • Original Article
  • Published:
Virchows Archiv Aims and scope Submit manuscript

Abstract

To determine patient and tumor characteristics that could predict pathologic findings after retroperitoneal lymph node dissection (RPLND) in paratesticular rhabdomyosarcoma (PTRMS), a total of 266 cases of PTRMS diagnosed between 1973 and 2010 were identified from a national database. RPLND dissection was performed in 67 patients, with a mean age of 14.9 years and median survival of 80 months. PTRMS occurred more often on the right side, had embryonal histology, and had an average size of 6.7 cm. Retroperitoneal lymph node (RPLN) metastasis occurred in 40 % (n = 27) of patients. Tumor size and age were strong predictors of finding rhabdomyosarcoma in the retroperitoneal lymph nodes when examined by pathologists. Primary tumors larger than 7 cm in size developing in males 12 years or older had four times more odds of being associated with positive findings on pathologic examinations of the retroperitoneal lymph nodes. Patient race, histology, and tumor laterality were not significant predictors of PTRMS metastasis to the RPLN basin. Patients 12 years or older with PTRMS larger than 7 cm have a significant risk of retroperitoneal lymph nodes involvement with PTRMS. Detailed pathologic examination of the lymph nodes in these patients is recommended.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Bianchi G, Charoenlap C, Cocchi S, Rani N, Campagnoni S, Righi A, Frisoni T, Donati DM (2014) Clear cell sarcoma of soft tissue: a retrospective review and analysis of 31 cases treated at Istituto Ortopedico Rizzoli. Eur J Surg Oncol: J Eur Soc Surg Oncol Br Assoc Surg Oncol. doi:10.1016/j.ejso.2014.01.016

    Google Scholar 

  2. Bosl GJ, Vogelzang NJ, Goldman A, Fraley EE, Lange PH, Levitt SH, Kennedy BJ (1981) Impact of delay in diagnosis on clinical stage of testicular cancer. Lancet 2:970–973

    Article  CAS  PubMed  Google Scholar 

  3. Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, Breneman J, Qualman SJ, Wiener E, Wharam M, Lobe T, Webber B, Maurer HM, Donaldson SS (2001) Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol 19:3091–3102

    CAS  PubMed  Google Scholar 

  4. Crowson MG, Lalich I, Keeney MG, Garcia JJ, Price DL (2014) Clinicopathologic factors and adjuvant treatment effects on survival in adult head & neck synovial cell sarcoma. Head Neck. doi:10.1002/hed.23605

    PubMed  Google Scholar 

  5. D’Angelo E, Espinosa I, Ali R, Gilks CB, Rijn M, Lee CH, Prat J (2011) Uterine leiomyosarcomas: tumor size, mitotic index, and biomarkers Ki67, and Bcl-2 identify two groups with different prognosis. Gynecol Oncol 121:328–333

    Article  PubMed  Google Scholar 

  6. Dang ND, Dang PT, Samuelian J, Paulino AC (2013) Lymph node management in patients with paratesticular rhabdomyosarcoma: a population-based analysis. Cancer 119:3228–3233. doi:10.1002/cncr.28198

    Article  PubMed  Google Scholar 

  7. Hays DM, Lawrence W Jr, Crist WM, Wiener E, Raney RB Jr, Ragab A, Tefft M, Webber B, Johnston J, Maurer HM (1990) Partial cystectomy in the management of Rhabdomyosarcoma of the bladder: a report from the intergroup Rhabdomyosarcoma study. J Pediatr Surg 25:719–723

    Article  CAS  PubMed  Google Scholar 

  8. Huynh TK, Meeus P, Cassier P, Bouche O, Lardiere-Deguelte S, Adenis A, Andre T, Mancini J, Collard O, Montemurro M, Bompas E, Rios M, Isambert N, Cupissol D, Blay JY, Duffaud F (2014) Primary localized rectal/pararectal gastrointestinal stromal tumors: results of surgical and multimodal therapy from the French sarcoma group BMC. Cancer 14:156. doi:10.1186/1471-2407-14-156

    PubMed Central  PubMed  Google Scholar 

  9. Moroni M, Nesi G, Travaglini F, Rizzo M, Amorosi A, Dominici A (2003) Rhabdomyosarcoma of the spermatic cord. A case report with review of the literature. Urol Int 71:114–117, 71108

    Article  PubMed  Google Scholar 

  10. Newton WA Jr, Soule EH, Hamoudi AB, Reiman HM, Shimada H, Beltangady M, Maurer H (1988) Histopathology of childhood sarcomas. Intergroup Rhabdomyosarcoma studies I and II: clinicopathologic correlation. J Clin Oncol Off J Am Soc Clin Oncol 6:67–75

    Google Scholar 

  11. Park JP, Roh JL, Lee JH, Baek JH, Gong G, Cho KJ, Choi SH, Nam SY, Kim SY (2014) Risk factors for central neck lymph node metastasis of clinically noninvasive, node-negative papillary thyroid microcarcinoma. Am J Surg. doi:10.1016/j.amjsurg.2013.10.032

    Google Scholar 

  12. Raney RB Jr, Tefft M, Lawrence W Jr, Ragab AH, Soule EH, Beltangady M, Gehan EA (1987) Paratesticular sarcoma in childhood and adolescence. A report from the intergroup Rhabdomyosarcoma studies I and II, 1973–1983. Cancer 60:2337–2343

    Article  PubMed  Google Scholar 

  13. Skoog SJ (1997) Benign and malignant pediatric scrotal masses. Pediatr Clin N Am 44:1229–1250

    Article  CAS  Google Scholar 

  14. Stephenson AJ, Klein EA (2009) Surgical management of low-stage nonseminomatous germ cell testicular cancer. BJU Int 104:1362–1368. doi:10.1111/j.1464-410X.2009.08860.x

    Article  PubMed  Google Scholar 

  15. Stevens MC, Rey A, Bouvet N, Ellershaw C, Flamant F, Habrand JL, Marsden HB, Martelli H, de Sanchez Toledo J, Spicer RD, Spooner D, Terrier-Lacombe MJ, van Unnik A, Oberlin O (2005) Treatment of nonmetastatic Rhabdomyosarcoma in childhood and adolescence: third study of the international society of paediatric oncology—SIOP malignant mesenchymal tumor 89. J Clin Oncol Off J Am Soc Clin Oncol 23:2618–2628. doi:10.1200/JCO.2005.08.130

    Article  Google Scholar 

  16. Wiener ES, Anderson JR, Ojimba JI, Lobe TE, Paidas C, Andrassy RJ, Raney RB, Qualman SJ, Donaldson SS, Maurer HM, Link MP, Crist WM, Grier HE (2001) Controversies in the management of paratesticular rhabdomyosarcoma: is staging retroperitoneal lymph node dissection necessary for adolescents with resected paratesticular rhabdomyosarcoma? Semin Pediatr Surg 10:146–152

    Article  CAS  PubMed  Google Scholar 

  17. Wiener ES, Lawrence W, Hays D, Lobe TE, Andrassy R, Donaldson S, Crist W, Newton W, Johnson J, Gehan E (1994) Retroperitoneal node biopsy in paratesticular rhabdomyosarcoma. J Pediatr Surg 29:171–177, discussion 178

    Article  CAS  PubMed  Google Scholar 

  18. Ye B, Cheng M, Ge XX, Geng JF, Li W, Feng J, Hu DZ, Zhao H (2014) Factors that predict lymph node status in clinical stage T1aN0M0 lung adenocarcinomas. World J Surg Oncol 12:42

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Conflicts of interest

The authors declare that they have no conflict of interests.

Author information

Authors and Affiliations

  1. Department of Surgery, Division of Urology and Division of Surgical Oncology, Southern Illinois University School of Medicine, PO Box 19665, Springfield, IL, 62794-9665, USA

    Shaheen Alanee, Bradley Holland & Sabha Ganai

  2. Center for Clinical Research, Southern Illinois University School of Medicine, PO Box 19665, Springfield, IL, 62794-9665, USA

    Danuta Dynda

  3. Department of Pathology, Southern Illinois University School of Medicine, PO Box 19665, Springfield, IL, 62794-9665, USA

    Onsi Kamel

Authors
  1. Shaheen Alanee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bradley Holland
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Danuta Dynda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Onsi Kamel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sabha Ganai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shaheen Alanee.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Alanee, S., Holland, B., Dynda, D. et al. Primary tumor size predicts pathologic findings in the retroperitoneal lymph nodes in patients with paratesticular rhabdomyosarcoma. Virchows Arch 465, 697–701 (2014). https://doi.org/10.1007/s00428-014-1663-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-014-1663-x

Keywords

Search

Navigation