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Basaloid carcinoma of the pancreas—clinicopathological presentation and oncogenetic snapshot of a rare entity

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Abstract

We report a case of basaloid pancreatic carcinoma with clinical, pathological, and genomic data. The 73-year-old male patient had jaundice, acholic stool, diarrhea, weight loss, and a large, painless gall bladder. His GGT was highly elevated. The pancreatic head contained a tumor, which was resected by partial pancreatoduodenectomy with pancreato-gastric anastomosis, cholecystectomy, and lymphadenectomy. On gross examination, a 3.8-cm white firm nodule was found, which microscopically was composed of basaloid cell nests with a less than usual desmoplastic stromal background and focally PANIN. Immunohistochemical profile displayed strong CK5/6, CK19, p63, EGFR, vimentin, and evident CK14 expression and absence of expression of CK7, chromogranin, synaptophysin, and BRCA1. A high Ki-67 index and p53 expression were noted. Sequencing of the most frequent 46 oncogenes with ionTorrent (AmpliSeq PCR) method identified PIK3CA, KRAS, and TP53 genes as drivers and variants of the FGFR3, PDGFRA, KIT, KDR, EGFR, RET, and ATM genes. The tumor we report displays histopathological appearances similar to the previously described case and a genomic landscape fitting to the general population of pancreatic carcinomas. We hypothesize that this tumor may belong to the group of DNA damage repair-deficient pancreatic carcinoma subgroup.

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Acknowledgments

The research study was supported by the European Union and the State of Hungary and cofinanced by the European Social Fund in the framework of TÁMOP 4.2.4.A/2-11-1-2012-0001 “National Excellence Program.”

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Authors and Affiliations

  1. 2nd Department of Pathology, Semmelweis University, Budapest, Hungary

    A. Marcell Szasz, Ildiko Szirtes, Bernadett Barkaszi, Jozsef Timar & Janina Kulka

  2. 1st Department of Surgery, Semmelweis University, Budapest, Hungary

    Balazs Tihanyi, Zsolt Baranyai, Tibor Tihanyi & Laszlo Harsanyi

  3. Tumour Progression Research Group, 2nd Department of Pathology, Semmelweis University and Hungarian Academy of Sciences, Budapest, Hungary

    Jozsef Timar

Authors
  1. A. Marcell Szasz
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  2. Ildiko Szirtes
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  3. Balazs Tihanyi
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  4. Bernadett Barkaszi
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  5. Zsolt Baranyai
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  6. Tibor Tihanyi
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  7. Laszlo Harsanyi
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  8. Jozsef Timar
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  9. Janina Kulka
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Corresponding author

Correspondence to Janina Kulka.

Additional information

A. Marcell Szasz, Ildiko Szirtes, and Balazs Tihanyi are equal first authors.

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Szasz, A.M., Szirtes, I., Tihanyi, B. et al. Basaloid carcinoma of the pancreas—clinicopathological presentation and oncogenetic snapshot of a rare entity. Virchows Arch 466, 237–241 (2015). https://doi.org/10.1007/s00428-014-1662-y

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  • DOI: https://doi.org/10.1007/s00428-014-1662-y

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