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Hybrid oncocytic/chromophobe renal cell tumours do not display genomic features of chromophobe renal cell carcinomas

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Abstract

Hybrid oncocytic/chromophobe tumours (HOCT) are renal tumours recently described displaying histological features of both renal oncocytoma (RO) and chromophobe renal cell carcinoma (ChRCC), raising the question of their precise signification in the RO/ChRCC group. This study aimed to describe clinicopathological features of so called HOCT and to characterise their genomic profile. Five hundred and eighty-three tumours belonging to the ChRCC/RO group were retrospectively reviewed. Twelve tumours that could not be classified as RO or CHRC were considered as HOCT. Hale staining and cytokeratin 7 (CK7) immunostaining were performed. Genomic profile was established by array comparative genomic hybridisation (array-CGH) on frozen samples. Mean age at diagnosis was 70 years (range 46–83). No recurrence was observed (median follow-up: 18 months; range 9–72). Tumour size ranged from 1 to 11 cm. HOCT showed an admixture of RO- and ChRCC-like areas and/or “hybrid” cells with overlapping cytonuclear and/or histochemical features. Hale staining was apical in 50 to 100 % of cells, and CK7 was expressed in 10 to 100 % of cells. Genomic profile was balanced in seven cases or showed a limited number of random imbalances in five cases, as observed in RO. In no instances were observed the characteristic chromosome losses of ChRCC. These results suggest that so called HOCT are not true hybrid tumours and rather could represent a morphological variant of RO. From a diagnostic perspective, an array-CGH analysis could be performed in ambiguous ChRCC/RO cases to formally exclude the diagnosis of ChRCC.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pathology, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris Descartes University, Paris, France

    Nicolas Poté, Annick Vieillefond & Mathilde Sibony

  2. Department of Genetics, Curie Institute, Paris, France

    Jérôme Couturier & Sandrine Arrufat

  3. Tumour bank, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris Descartes University, Paris, France

    Isabelle Metzger

  4. Department of Urology, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris Descartes University, Paris, France

    Nicolas B. Delongchamps

  5. Department of Pathology, Foch Hospital, Suresnes, France

    Philippe Camparo

  6. Department of Pathology, Edouard-Herriot Hospital, Lyon, France

    Florence Mège-Lechevallier

  7. Department of Pathology, Saint-Joseph Hospital, Paris, France

    Vincent Molinié

  8. Service d’Anatomie Pathologique, Hôpital Cochin, 27 rue du Faubourg Saint Jacques, 75014, Paris, France

    Mathilde Sibony

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  1. Nicolas Poté
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  2. Annick Vieillefond
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  6. Nicolas B. Delongchamps
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  7. Philippe Camparo
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  8. Florence Mège-Lechevallier
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  9. Vincent Molinié
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  10. Mathilde Sibony
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Correspondence to Mathilde Sibony.

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Poté, N., Vieillefond, A., Couturier, J. et al. Hybrid oncocytic/chromophobe renal cell tumours do not display genomic features of chromophobe renal cell carcinomas. Virchows Arch 462, 633–638 (2013). https://doi.org/10.1007/s00428-013-1422-4

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  • DOI: https://doi.org/10.1007/s00428-013-1422-4

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