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Primary pulmonary malignant meningioma with lymph node and liver metastasis in a centenary woman, an autopsy case

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Abstract

Primary meningiomas arising outside the central nervous system are very rare. They have been reported in the head and neck region, in the thorax, the retroperitoneum, and the pelvis. Usually, they behave as slow-growing tumors with a good prognosis. Herein, we report an autopsy case of a 108-year-old woman, known for a right-sided slowly growing lung nodule for 39 years. Death was attributed to cachexia. At post-mortem, a 15-cm mass was present in the right inferior lobe of the lung, associated with an ipsilateral hilar lymphadenopathy, and another 10-cm mass in the liver. Histology revealed a WHO grade III meningioma. No tumor was observed in the cranial cavity. This case illustrates a rare location of meningioma and highlights its biological behavior, with a very slow progression from a most probably benign tumor to a malignant lesion with metastasis over four decades.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Division of Primary Care, University Hospital Geneva, Geneva, Switzerland

    Catherine Weber & Sophie Pautex

  2. Department of Clinical Pathology, University Hospital Geneva, CMU – 1, rue Michel-Servet, 1211, Geneva 4, Switzerland

    Marc Pusztaszeri & Johannes Alexander Lobrinus

  3. Division of Palliative Medicine, University Hospital Geneva, Geneva, Switzerland

    Sophie Pautex & Gilbert B. Zulian

  4. Division of Medical Readaptation, University Hospital Geneva, Geneva, Switzerland

    Catherine Weber

Authors
  1. Catherine Weber
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  2. Sophie Pautex
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  3. Gilbert B. Zulian
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  4. Marc Pusztaszeri
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  5. Johannes Alexander Lobrinus
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Correspondence to Johannes Alexander Lobrinus.

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Weber, C., Pautex, S., Zulian, G.B. et al. Primary pulmonary malignant meningioma with lymph node and liver metastasis in a centenary woman, an autopsy case. Virchows Arch 462, 481–485 (2013). https://doi.org/10.1007/s00428-013-1383-7

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  • DOI: https://doi.org/10.1007/s00428-013-1383-7

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