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Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study

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An Erratum to this article was published on 26 July 2012

Abstract

Now that more than two decades have passed since the first reports of intraductal papillary-mucinous neoplasms (IPMNs), it has become clear that IPMN consists of a spectrum of neoplasms with both morphological and immunohistochemical variations. At a meeting of international experts on pancreatic precursor lesions held in 2003, it was agreed that a consensus classification of IPMN subtypes should be established to enable a more detailed analysis of the clinicopathological significance of the variations. Based on our experience and on information from the literature, we selected representative histological examples of IPMNs and defined a consensus nomenclature and criteria for classifying variants as distinctive IPMN subtypes including gastric type, intestinal type, pancreatobiliary type, and oncocytic type. These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN.

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Acknowledgements

We thank Ms. Naomi Kanai for technical assistance and Ms. Kay Dege for editing the manuscript.

Author information

Authors and Affiliations

  1. Department of Molecular Pathology, Tohoku University School of Medicine, 2-1 Seiryomachi, Aoba-ku, Sendai, 980-8575, Japan

    Toru Furukawa & Akira Horii

  2. Department of Pathology, University of Kiel, Kiel, Germany

    Günter Klöppel & Jutta Lüttges

  3. Department of Pathology, Wayne State University, Detroit, MI, USA

    N. Volkan Adsay

  4. Department of Pathology, LSU Health Sciences Center, Shreveport, LA, USA

    Jorge Albores-Saavedra

  5. Department of Pathology, Tokyo Medical College, Tokyo, Japan

    Noriyoshi Fukushima

  6. Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA

    Ralph H. Hruban

  7. Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan

    Yo Kato

  8. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    David S. Klimstra

  9. Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA

    Daniel S. Longnecker & Arief Suriawinata

  10. Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands

    G. Johan A. Offerhaus

  11. Department of Pathology, Saitama Medical School, Saitama, Japan

    Michio Shimizu

  12. Department of Gastroenterological Surgery, Tohoku University School of Medicine, Sendai, Japan

    Makoto Sunamura

  13. Department of General and Gastroenterological Surgery, Osaka Medical College, Osaka, Japan

    Kyoichi Takaori

  14. Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

    Suguru Yonezawa

Authors
  1. Toru Furukawa
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  2. Günter Klöppel
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  3. N. Volkan Adsay
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  5. Noriyoshi Fukushima
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  6. Akira Horii
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  7. Ralph H. Hruban
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  8. Yo Kato
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  9. David S. Klimstra
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  10. Daniel S. Longnecker
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  11. Jutta Lüttges
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  12. G. Johan A. Offerhaus
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  13. Michio Shimizu
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  14. Makoto Sunamura
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  15. Arief Suriawinata
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  16. Kyoichi Takaori
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  17. Suguru Yonezawa
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Corresponding author

Correspondence to Toru Furukawa.

Additional information

This work was supported in part by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan, the Pancreas Research Foundation of Japan, the Gonryo Medical Foundation, and NIH SPORE (Specialized Programs of Research Excellence) in Gastrointestinal Cancer Grant CA62924.

An erratum to this article can be found at http://dx.doi.org/10.1007/s00428-012-1260-9

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Furukawa, T., Klöppel, G., Volkan Adsay, N. et al. Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study. Virchows Arch 447, 794–799 (2005). https://doi.org/10.1007/s00428-005-0039-7

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  • DOI: https://doi.org/10.1007/s00428-005-0039-7

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