, Volume 447, Issue 5, pp 794-799
Date: 09 Aug 2005

Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Now that more than two decades have passed since the first reports of intraductal papillary-mucinous neoplasms (IPMNs), it has become clear that IPMN consists of a spectrum of neoplasms with both morphological and immunohistochemical variations. At a meeting of international experts on pancreatic precursor lesions held in 2003, it was agreed that a consensus classification of IPMN subtypes should be established to enable a more detailed analysis of the clinicopathological significance of the variations. Based on our experience and on information from the literature, we selected representative histological examples of IPMNs and defined a consensus nomenclature and criteria for classifying variants as distinctive IPMN subtypes including gastric type, intestinal type, pancreatobiliary type, and oncocytic type. These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN.

This work was supported in part by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan, the Pancreas Research Foundation of Japan, the Gonryo Medical Foundation, and NIH SPORE (Specialized Programs of Research Excellence) in Gastrointestinal Cancer Grant CA62924.
An erratum to this article can be found at http://dx.doi.org/10.1007/s00428-012-1260-9