Virchows Archiv

, Volume 447, Issue 5, pp 794–799

Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study

Authors

    • Department of Molecular PathologyTohoku University School of Medicine
  • Günter Klöppel
    • Department of PathologyUniversity of Kiel
  • N. Volkan Adsay
    • Department of PathologyWayne State University
  • Jorge Albores-Saavedra
    • Department of PathologyLSU Health Sciences Center
  • Noriyoshi Fukushima
    • Department of PathologyTokyo Medical College
  • Akira Horii
    • Department of Molecular PathologyTohoku University School of Medicine
  • Ralph H. Hruban
    • Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research CenterThe Johns Hopkins Medical Institutions
  • Yo Kato
    • Department of Pathology, Cancer InstituteJapanese Foundation for Cancer Research
  • David S. Klimstra
    • Department of PathologyMemorial Sloan-Kettering Cancer Center
  • Daniel S. Longnecker
    • Department of PathologyDartmouth-Hitchcock Medical Center
  • Jutta Lüttges
    • Department of PathologyUniversity of Kiel
  • G. Johan A. Offerhaus
    • Department of PathologyAcademic Medical Center
  • Michio Shimizu
    • Department of PathologySaitama Medical School
  • Makoto Sunamura
    • Department of Gastroenterological SurgeryTohoku University School of Medicine
  • Arief Suriawinata
    • Department of PathologyDartmouth-Hitchcock Medical Center
  • Kyoichi Takaori
    • Department of General and Gastroenterological SurgeryOsaka Medical College
  • Suguru Yonezawa
    • Department of Human Pathology, Field of OncologyKagoshima University Graduate School of Medical and Dental Sciences
Original Article

DOI: 10.1007/s00428-005-0039-7

Cite this article as:
Furukawa, T., Klöppel, G., Volkan Adsay, N. et al. Virchows Arch (2005) 447: 794. doi:10.1007/s00428-005-0039-7

Abstract

Now that more than two decades have passed since the first reports of intraductal papillary-mucinous neoplasms (IPMNs), it has become clear that IPMN consists of a spectrum of neoplasms with both morphological and immunohistochemical variations. At a meeting of international experts on pancreatic precursor lesions held in 2003, it was agreed that a consensus classification of IPMN subtypes should be established to enable a more detailed analysis of the clinicopathological significance of the variations. Based on our experience and on information from the literature, we selected representative histological examples of IPMNs and defined a consensus nomenclature and criteria for classifying variants as distinctive IPMN subtypes including gastric type, intestinal type, pancreatobiliary type, and oncocytic type. These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN.

Keywords

Pancreatic tumorIntraductal papillary-mucinous neoplasmClassificationMUC

Copyright information

© Springer-Verlag 2005