Original Article

Virchows Archiv

, Volume 447, Issue 5, pp 794-799

Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study

  • Toru FurukawaAffiliated withDepartment of Molecular Pathology, Tohoku University School of Medicine Email author 
  • , Günter KlöppelAffiliated withDepartment of Pathology, University of Kiel
  • , N. Volkan AdsayAffiliated withDepartment of Pathology, Wayne State University
  • , Jorge Albores-SaavedraAffiliated withDepartment of Pathology, LSU Health Sciences Center
  • , Noriyoshi FukushimaAffiliated withDepartment of Pathology, Tokyo Medical College
  • , Akira HoriiAffiliated withDepartment of Molecular Pathology, Tohoku University School of Medicine
  • , Ralph H. HrubanAffiliated withDepartments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions
  • , Yo KatoAffiliated withDepartment of Pathology, Cancer Institute, Japanese Foundation for Cancer Research
  • , David S. KlimstraAffiliated withDepartment of Pathology, Memorial Sloan-Kettering Cancer Center
    • , Daniel S. LongneckerAffiliated withDepartment of Pathology, Dartmouth-Hitchcock Medical Center
    • , Jutta LüttgesAffiliated withDepartment of Pathology, University of Kiel
    • , G. Johan A. OfferhausAffiliated withDepartment of Molecular Pathology, Tohoku University School of MedicineDepartment of Pathology, Academic Medical Center
    • , Michio ShimizuAffiliated withDepartment of Molecular Pathology, Tohoku University School of MedicineDepartment of Pathology, Saitama Medical School
    • , Makoto SunamuraAffiliated withDepartment of Molecular Pathology, Tohoku University School of MedicineDepartment of Gastroenterological Surgery, Tohoku University School of Medicine
    • , Arief SuriawinataAffiliated withDepartment of Pathology, Dartmouth-Hitchcock Medical Center
    • , Kyoichi TakaoriAffiliated withDepartment of Molecular Pathology, Tohoku University School of MedicineDepartment of General and Gastroenterological Surgery, Osaka Medical College
    • , Suguru YonezawaAffiliated withDepartment of Molecular Pathology, Tohoku University School of MedicineDepartment of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences

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Abstract

Now that more than two decades have passed since the first reports of intraductal papillary-mucinous neoplasms (IPMNs), it has become clear that IPMN consists of a spectrum of neoplasms with both morphological and immunohistochemical variations. At a meeting of international experts on pancreatic precursor lesions held in 2003, it was agreed that a consensus classification of IPMN subtypes should be established to enable a more detailed analysis of the clinicopathological significance of the variations. Based on our experience and on information from the literature, we selected representative histological examples of IPMNs and defined a consensus nomenclature and criteria for classifying variants as distinctive IPMN subtypes including gastric type, intestinal type, pancreatobiliary type, and oncocytic type. These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN.

Keywords

Pancreatic tumor Intraductal papillary-mucinous neoplasm Classification MUC