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The role of protein–protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3

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Abstract

The intracellular transport of membrane proteins is controlled by trafficking signals: Short peptide motifs that mediate the contact with COPI, COPII or various clathrin-associated coat proteins. In addition, many membrane proteins interact with accessory proteins that are involved in the sorting of these proteins to different intracellular compartments. In the K2P channels, TASK-1 and TASK-3, the influence of protein–protein interactions on sorting decisions has been studied in some detail. Both TASK paralogues interact with the adaptor protein 14-3-3; TASK-1 interacts, in addition, with the adaptor protein p11 (S100A10) and the endosomal SNARE protein syntaxin-8. The role of these interacting proteins in controlling the intracellular traffic of the channels and the underlying molecular mechanisms are summarised in this review. In the case of 14-3-3, the interacting protein masks a retention signal in the C-terminus of the channel; in the case of p11, the interacting protein carries a retention signal that localises the channel to the endoplasmic reticulum; and in the case of syntaxin-8, the interacting protein carries an endocytosis signal that complements an endocytosis signal of the channel. These examples illustrate some of the mechanisms by which interacting proteins may determine the itinerary of a membrane protein within a cell and suggest that the intracellular traffic of membrane proteins may be adapted to the specific functions of that protein by multiple protein–protein interactions.

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Acknowledgments

This study was supported by the Deutsche Forschungsgemeinschaft (FOR 1086, TP7 and TP9; SFB 593, TP4).

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Authors and Affiliations

  1. Institute of Physiology and Pathophysiology, Marburg University, 35037, Marburg, Germany

    Vijay Renigunta & Jürgen Daut

  2. Institute of Molecular Biology, Göttingen University, 37073, Göttingen, Germany

    Markus Kilisch, Olga Lytovchenko & Blanche Schwappach

Authors
  1. Markus Kilisch
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  2. Olga Lytovchenko
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  3. Blanche Schwappach
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  4. Vijay Renigunta
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  5. Jürgen Daut
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Corresponding authors

Correspondence to Vijay Renigunta or Jürgen Daut.

Additional information

Markus Kilisch and Olga Lytovchenko contributed equally.

This article is published as part of the special issue on K2P-channels.

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Kilisch, M., Lytovchenko, O., Schwappach, B. et al. The role of protein–protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3. Pflugers Arch - Eur J Physiol 467, 1105–1120 (2015). https://doi.org/10.1007/s00424-014-1672-2

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  • DOI: https://doi.org/10.1007/s00424-014-1672-2

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