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Noise-induced alterations in cochlear mechanics, electromotility, and cochlear amplification

  • Sensory Physiology
  • Published:
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Abstract

Loud sounds are a common cause of hearing loss. Very intense sounds may result in permanent hearing loss, but lower levels typically cause a transient decrease in auditory sensitivity. Studies have arrived at different conclusions as regards the physiological mechanisms underlying such temporary threshold shifts. Here, we investigated the effect of acoustic overstimulation on the mechanics of the low-frequency areas of the guinea pig cochlea. We demonstrate that brief loud sound exposure results in an increased phase lag and a paradoxical frequency-specific increase of sound-evoked displacement. Despite the increased displacement, electrically evoked motion is reduced. Because electromotility is important for amplifying low-level sounds, this change was associated with a decrease in measures of cochlear amplification. These changes recovered over the course of 30–40 min. Overstimulation also caused an increase in cytoplasmic calcium levels of both hair cells and supporting cells. These data suggest that reduced organ of Corti stiffness contributes to temporary threshold shifts.

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Acknowledgments

The study was supported by the Swedish Research Council (K2011-63X-14061-11-3), Hörselskadades Riksförbund, the foundation Tysta Skolan, and the Research Council for Working Life and Social Research (2006-1526). We thank Dr. Richard Chadwick for helpful comments.

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Authors and Affiliations

  1. Center for Hearing and Communication Research, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden

    Stefan Jacob, Cecilia Johansson & Anders Fridberger

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  1. Stefan Jacob
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  2. Cecilia Johansson
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  3. Anders Fridberger
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Correspondence to Anders Fridberger.

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Stefan Jacob and Cecilia Johansson contributed equally

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Jacob, S., Johansson, C. & Fridberger, A. Noise-induced alterations in cochlear mechanics, electromotility, and cochlear amplification. Pflugers Arch - Eur J Physiol 465, 907–917 (2013). https://doi.org/10.1007/s00424-012-1198-4

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  • DOI: https://doi.org/10.1007/s00424-012-1198-4

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