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Metabolic rate regulation by the renin–angiotensin system: brain vs. body

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Abstract

Substantial evidence supports a role for the renin–angiotensin system (RAS) in the regulation of metabolic function, but an apparent paradox exists where genetic or pharmacological inhibition of the RAS occasionally has similar physiological effects as chronic angiotensin infusion. Similarly, while RAS targeting in animal models has robust metabolic consequences, effects in humans are more subtle. Here, we review the data supporting a role for the RAS in metabolic rate regulation and propose a model where the local brain RAS works in opposition to the peripheral RAS, thus helping to explain the paradoxically similar effects of RAS supplementation and inhibition. Selectively modulating the peripheral RAS or brain RAS may thus provide a more effective treatment paradigm for obesity and obesity-related disorders.

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Acknowledgments

This work was supported by research grants from the US National Institutes of Health including HL098276 to JLG, HL014388 to KR, HL084207 to CDS and KR, and HL048058 and HL061446 to CDS. KR was also supported by a grant (1-11-BS-127) from the American Diabetes Association. The authors also gratefully acknowledge the generous support of the Roy J. Carver Trust.

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  1. Department of Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 3181 MERF, 375 Newton Rd., Iowa City, IA, 52242, USA

    Justin L. Grobe, Kamal Rahmouni, Xuebo Liu & Curt D. Sigmund

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  1. Justin L. Grobe
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  2. Kamal Rahmouni
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  4. Curt D. Sigmund
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Correspondence to Curt D. Sigmund.

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This article is published as part of the special issue on the Renin-Angiotensin System.

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Grobe, J.L., Rahmouni, K., Liu, X. et al. Metabolic rate regulation by the renin–angiotensin system: brain vs. body. Pflugers Arch - Eur J Physiol 465, 167–175 (2013). https://doi.org/10.1007/s00424-012-1096-9

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