Pflügers Archiv - European Journal of Physiology

, Volume 465, Issue 1, pp 167–175

Metabolic rate regulation by the renin–angiotensin system: brain vs. body

Authors

  • Justin L. Grobe
    • Department of Pharmacology, Roy J. and Lucille A. Carver College of MedicineUniversity of Iowa
  • Kamal Rahmouni
    • Department of Pharmacology, Roy J. and Lucille A. Carver College of MedicineUniversity of Iowa
  • Xuebo Liu
    • Department of Pharmacology, Roy J. and Lucille A. Carver College of MedicineUniversity of Iowa
    • Department of Pharmacology, Roy J. and Lucille A. Carver College of MedicineUniversity of Iowa
Invited Review

DOI: 10.1007/s00424-012-1096-9

Cite this article as:
Grobe, J.L., Rahmouni, K., Liu, X. et al. Pflugers Arch - Eur J Physiol (2013) 465: 167. doi:10.1007/s00424-012-1096-9

Abstract

Substantial evidence supports a role for the renin–angiotensin system (RAS) in the regulation of metabolic function, but an apparent paradox exists where genetic or pharmacological inhibition of the RAS occasionally has similar physiological effects as chronic angiotensin infusion. Similarly, while RAS targeting in animal models has robust metabolic consequences, effects in humans are more subtle. Here, we review the data supporting a role for the RAS in metabolic rate regulation and propose a model where the local brain RAS works in opposition to the peripheral RAS, thus helping to explain the paradoxically similar effects of RAS supplementation and inhibition. Selectively modulating the peripheral RAS or brain RAS may thus provide a more effective treatment paradigm for obesity and obesity-related disorders.

Keywords

ObesityMetabolismEnergy homeostasisThermogenesis

Copyright information

© Springer-Verlag 2012