Pflügers Archiv - European Journal of Physiology

, Volume 463, Issue 1, pp 15–22

A metabolic–transcriptional network links sleep and cellular energetics in the brain

Authors

    • WWAMI Medical Education Program and Department Of Veterinary Comparative Anatomy, Pharmacology and PhysiologyWashington State University
Invited Review

DOI: 10.1007/s00424-011-1030-6

Cite this article as:
Wisor, J.P. Pflugers Arch - Eur J Physiol (2012) 463: 15. doi:10.1007/s00424-011-1030-6

Abstract

This review proposes a mechanistic link between cellular metabolic status, transcriptional regulatory changes and sleep. Sleep loss is associated with changes in cellular metabolic status in the brain. Metabolic sensors responsive to cellular metabolic status regulate the circadian clock transcriptional network. Modifications of the transcriptional activity of circadian clock genes affect sleep/wake state changes. Changes in sleep state reverse sleep loss-induced changes in cellular metabolic status. It is thus proposed that the regulation of circadian clock genes by cellular metabolic sensors is a critical intermediate step in the link between cellular metabolic status and sleep. Studies of this regulatory relationship may offer insights into the function of sleep at the cellular level.

Keywords

Nicotinamide adenine dinucleotideAdenosine triphosphateSlow wave activitySleepCircadianAdenosine monophosphate-activated protein kinaseGlycogenSirtuinPoly(ADP)ribosyl polymerasePeroxisome proliferator-activated receptor

Abbreviations

NREMS

Non-rapid eye movement sleep

SWA

Slow wave activity

EEG

Electroencephalographic/electroencephalogram

ATP

Adenosine triphosphate

ADP

Adenosine diphosphate

AMP

Adenosine monophosphate

AMPK

Adenosine monophosphate-activated protein kinase

cry

Cryptochrome

per

Period

NAD

Nicotine adenine dinucleotide

HDAC

Histone deacetylase

PARP

Poly ADP-ribose polymerase

GSK3b

Glycogen synthase kinase 3b

PPARs

Peroxisome proliferator-activated receptors

Copyright information

© Springer-Verlag 2011