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Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases

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Abstract

Phosphatidylinositol (4,5)-bisphosphate (PIP2) is an important lipid mediator that has multiple regulatory functions. There is now increasing evidence that the phosphatidylinositol 4-phosphate 5 kinases (PIP5Ks), which synthesize PIP2, are regulated spatially and temporally and that they have isoform-specific functions and regulations. This review will summarize the highlights of recent developments in understanding how the three major PIP5K isoforms regulate the actin cytoskeleton and other important cellular processes.

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Acknowledgments

This work is supported by NIH R01GM06110, NIH P05GM21681, and a Welch Foundation grant to HLY.

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  1. Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9040, USA

    Yuntao S. Mao & Helen L. Yin

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Correspondence to Helen L. Yin.

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Mao, Y.S., Yin, H.L. Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases. Pflugers Arch - Eur J Physiol 455, 5–18 (2007). https://doi.org/10.1007/s00424-007-0286-3

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