Original Article

European Journal of Applied Physiology

, Volume 113, Issue 10, pp 2577-2586

Effect of cryotherapy on muscle recovery and inflammation following a bout of damaging exercise

  • Naomi J. CrystalAffiliated withRobert Kertzer Exercise Physiology Laboratory, University of New HampshireDepartment of Kinesiology, University of New Hampshire
  • , David H. TownsonAffiliated withDepartment of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire
  • , Summer B. CookAffiliated withRobert Kertzer Exercise Physiology Laboratory, University of New HampshireDepartment of Kinesiology, University of New Hampshire
  • , Dain P. LaRocheAffiliated withRobert Kertzer Exercise Physiology Laboratory, University of New HampshireDepartment of Kinesiology, University of New Hampshire Email author 

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Abstract

The purpose of this study was to determine the effect of cryotherapy on the inflammatory response to muscle-damaging exercise using a randomized trial. Twenty recreationally active males completed a 40-min run at a −10 % grade to induce muscle damage. Ten of the subjects were immersed in a 5 °C ice bath for 20 min and the other ten served as controls. Knee extensor peak torque, soreness rating, and thigh circumference were obtained pre- and post-run, and 1, 6, 24, 48, and 72 h post-run. Blood samples were obtained pre- and post-run, and 1, 6 and 24 h post-run for assay of plasma chemokine ligand 2 (CCL2). Peak torque decreased from 270 ± 57 Nm at baseline to 253 ± 65 Nm post-run and increased to 295 ± 68 Nm by 72 h post-run with no differences between groups (p = 0.491). Soreness rating increased from 3.6 ± 6.0 mm out of 100 mm at baseline to 47.4 ± 28.2 mm post-run and remained elevated at all time points with no differences between groups (p = 0.696). CCL2 concentrations increased from 116 ± 31 pg mL−1 at baseline to 293 ± 109 pg mL−1 at 6 h post-run (control) and from 100 ± 27 pg mL−1 at baseline to 208 ± 71 pg mL−1 at 6 h post-run (cryotherapy). The difference between groups was not significant (p = 0.116), but there was a trend for lower CCL2 in the cryotherapy group at 6 h (p = 0.102), though this measure was highly variable. In conclusion, 20 min of cryotherapy was ineffective in attenuating the strength decrement and soreness seen after muscle-damaging exercise, but may have mitigated the rise in plasma CCL2 concentration. These results do not support the use of cryotherapy during recovery.

Keywords

Eccentric exercise Downhill run Inflammation Chemokine ligand-2