Abstract
It is well documented that a single bout of endurance exercise (EE) can improve insulin sensitivity, whereas relatively little is known about the acute effects of resistance exercise (RE) in humans. The objective of this study is to investigate the insulin and glucose responses to an oral glucose tolerance test (OGTT) following a high intensity bout of either EE or RE followed by post-exercise carbohydrate–protein hydrolysate ingestion. Eighteen participants were divided into two groups: a group in which nine participants completed 1 h of EE (cycle ergometry at 75% W max) and a RE group in which nine participants completed a RE circuit (3 sets of 10 repetitions). Participants ingested 1.5 l of a carbohydrate (200 g)–protein hydrolysate (50 g) beverage within 1 h of exercise completion. An OGTT was performed 6 h post-exercise. On the control day the endurance and resistance groups performed the above protocol without the prior exercise (CEE or CRE). The control and exercise days were counterbalanced. RE reduced plasma glucose AUC (822 ± 68 vs. 694 ± 23 mmol l−1·120 min; CRE vs. RE, respectively; P < 0.05) but EE did not lead to a change (784 ± 40 vs. 835 ± 59 mmol l−1·120 min; CEE vs. EE, respectively). Plasma insulin AUC remained unchanged compared to the control in both the RE and EE groups. The results suggest that the benefit of RE on glucose tolerance following CHO intake remains for 6 h even when a carbohydrate–protein hydrolysate beverage was ingested within 1 h after exercise, while the well documented benefit of EE was not observed.
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References
Bruce CR, Thrush AB, Mertz VA, Bezaire V, Chabowski A, Heigenhauser GJ et al (2006) Endurance training in obese humans improves glucose tolerance, mitochondrial fatty acid oxidation and alters muscle lipid content. Am J Physiol Endocrinol Metab 291(1):E99–E107
Craig BW, Everhart J, Brown R (1989) The influence of high-resistance training on glucose tolerance in young and elderly subjects. Mech Ageing Dev 49(2):147–157
Creer A, Gallagher P, Slivka D, Jemiolo B, Fink W, Trappe S (2005) Influence of muscle glycogen availability on erk1/2 and akt signaling after resistance exercise in human skeletal muscle. J Appl Physiol 99(3):950–956
Dela F, Mikines KJ, von Linstow M, Secher NH, Galbo H (1992) Effect of training on insulin-mediated glucose uptake in human muscle. Am J Physiol 263(6 Pt 1):E1134–E1143
Dela F, Larsen JJ, Mikines KJ, Ploug T, Petersen LN, Galbo H (1995) Insulin-stimulated muscle glucose clearance in patients with NIDDM. Effects of one-legged physical training. Diabetes 44(9):1010–1020
Derave W, Hansen BF, Lund S, Kristiansen S, Richter EA (2000) Muscle glycogen content affects insulin-stimulated glucose transport and protein kinase b activity. Am J Physiol Endocrinol Metab 279(5):E947–E955
Fenicchia LM, Kanaley JA, Azevedo JL Jr, Miller CS, Weinstock RS, Carhart RL et al (2004) Influence of resistance exercise training on glucose control in women with type 2 diabetes. Metabolism 53(3):284–289
Fluckey JD, Hickey MS, Brambrink JK, Hart KK, Alexander K, Craig BW (1994) Effects of resistance exercise on glucose tolerance in normal and glucose-intolerant subjects. J Appl Physiol 77(3):1087–1092
Hernandez JM, Fedele MJ, Farrell PA (2000) Time course evaluation of protein synthesis and glucose uptake after acute resistance exercise in rats. J Appl Physiol 88(3):1142–1149
Holten MK, Zacho M, Gaster M, Juel C, Wojtaszewski JF, Dela F (2004) Strength training increases insulin-mediated glucose uptake, glut4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes 53(2):294–305
Houmard JA, Shaw CD, Hickey MS, Tanner CJ (1999) Effect of short-term exercise training on insulin-stimulated pi 3-kinase activity in human skeletal muscle. Am J Physiol 277(6 Pt 1):E1055–E1060
Houmard JA, Tanner CJ, Slentz CA, Duscha BD, McCartney JS, Kraus WE (2004) Effect of the volume and intensity of exercise training on insulin sensitivity. J Appl Physiol 96(1):101–106
Ibanez J, Izquierdo M, Arguelles I, Forga L, Larrion JL, Garcia-Unciti M et al (2005) Twice-weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes. Diabetes Care 28(3):662–667
Ivy JL, Zderic TW, Fogt DL (1999) Prevention and treatment of non-insulin-dependent diabetes mellitus. Exerc Sport Sci Rev 27:1–35
King DS, Dalsky GP, Staten MA, Clutter WE, Van Houten DR, Holloszy JO (1987) Insulin action and secretion in endurance-trained and untrained humans. J Appl Physiol 63(6):2247–2252
Koopman R, Manders RJ, Jonkers RA, Hul GB, Kuipers H, van Loon LJ (2005a) Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males. Eur J Appl Physiol 96:1–10
Koopman R, Manders RJ, Zorenc AH, Hul GB, Kuipers H, Keizer HA et al (2005b) A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy men. Eur J Appl Physiol 94(1–2):180–187
Koopman R, Zorenc AH, Gransier RJ, Cameron-Smith D, van Loon LJ (2006) The increase in s6k1 phosphorylation in human skeletal muscle following resistance exercise occurs mainly in type II muscle fibers. Am J Physiol Endocrinol Metab 290
Krisan AD, Collins DE, Crain AM, Kwong CC, Singh MK, Bernard JR et al (2004) Resistance training enhances components of the insulin signaling cascade in normal and high-fat-fed rodent skeletal muscle. J Appl Physiol 96(5):1691–1700
Lohmann D, Liebold F, Heilmann W, Senger H, Pohl A (1978) Diminished insulin response in highly trained athletes. Metabolism 27(5):521–524
van Loon LJ, Saris WH, Kruijshoop M, Wagenmakers AJ (2000) Maximizing postexercise muscle glycogen synthesis: carbohydrate supplementation and the application of amino acid or protein hydrolysate mixtures. Am J Clin Nutr 72(1):106–111
Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22(9):1462–1470
Mikines KJ, Sonne B, Farrell PA, Tronier B, Galbo H (1988) Effect of physical exercise on sensitivity and responsiveness to insulin in humans. Am J Physiol 254(3 Pt 1):E248–E259
Miller WJ, Sherman WM, Ivy JL (1984) Effect of strength training on glucose tolerance and post-glucose insulin response. Med Sci Sports Exerc 16(6):539–543
Miller JP, Pratley RE, Goldberg AP, Gordon P, Rubin M, Treuth MS et al (1994) Strength training increases insulin action in healthy 50- to 65-yr-old men. J Appl Physiol 77(3):1122–1127
Nielsen JN, Derave W, Kristiansen S, Ralston E, Ploug T, Richter EA (2001) Glycogen synthase localization and activity in rat skeletal muscle is strongly dependent on glycogen content. J Physiol 531(Pt 3):757–769
Perseghin G, Price TB, Petersen KF, Roden M, Cline GW, Gerow K et al (1996) Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med 335(18):1357–1362
Reitman JS, Vasquez B, Klimes I, Nagulesparan M (1984) Improvement of glucose homeostasis after exercise training in non-insulin-dependent diabetes. Diabetes Care 7(5):434–441
Richter EA, Mikines KJ, Galbo H, Kiens B (1989) Effect of exercise on insulin action in human skeletal muscle. J Appl Physiol 66(2):876–885
Richter EA, Derave W, Wojtaszewski JF (2001) Glucose, exercise and insulin: emerging concepts. J Physiol 535(Pt 2):313–322
Rodnick KJ, Haskell WL, Swislocki AL, Foley JE, Reaven GM (1987) Improved insulin action in muscle, liver, and adipose tissue in physically trained human subjects. Am J Physiol 253(5 Pt 1):E489–E495
Wojtaszewski JF, Hansen BF, Kiens B, Richter EA (1997) Insulin signaling in human skeletal muscle: time course and effect of exercise. Diabetes 46(11):1775–1781
Wojtaszewski JF, Hansen BF, Gade Kiens B, Markuns JF, Goodyear LJ et al (2000) Insulin signaling and insulin sensitivity after exercise in human skeletal muscle. Diabetes 49(3):325–331
Yan Z, Spencer MK, Katz A (1992) Effect of low glycogen on glycogen synthase in human muscle during and after exercise. Acta Physiol Scand 145(4):345–352
Yaspelkis BB III, Singh MK, Trevino B, Krisan AD, Collins DE (2002) Resistance training increases glucose uptake and transport in rat skeletal muscle. Acta Physiol Scand 175(4):315–323
Zachwieja JJ, Costill DL, Pascoe DD, Robergs RA, Fink WJ (1991) Influence of muscle glycogen depletion on the rate of resynthesis. Med Sci Sports Exerc 23(1):44–48
Zawadzki KM, Yaspelkis BB III, Ivy JL (1992) Carbohydrate–protein complex increases the rate of muscle glycogen storage after exercise. J Appl Physiol 72(5):1854–1859
Acknowledgment
The authors would like to thank Paula Hendricks, Zoe Jessop, Laura Wright and Oliver Morley for their assistance in this study.
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Michelle C. Venables and Christopher S. Shaw made equal contributions to the studies and the writing of the manuscript and should be regarded as joint first author.
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Venables, M.C., Shaw, C.S., Jeukendrup, A.E. et al. Effect of acute exercise on glucose tolerance following post-exercise feeding. Eur J Appl Physiol 100, 711–717 (2007). https://doi.org/10.1007/s00421-007-0464-1
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DOI: https://doi.org/10.1007/s00421-007-0464-1