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Effects of acupuncture on heart rate variability in normal subjects under fatigue and non-fatigue state

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Abstract

The objective of this study was to assess the effects of acupuncture applied at Hegu (LI 4) points and Neiguan (PC6) points on heart rate variability (HRV) in normal subjects under fatigue and non-fatigue states using power spectral analysis. Twenty-nine normal male subjects were randomly divided into three groups. Subjects in Group A and Group B performed a simulated driving task for 3 h and acupuncture needles were then inserted perpendicularly into the LI 4 points in the middle of the dorsal thenar muscle and PC 6 points situated between the tendons of the palmaris longus and carpi radialis muscles for 15 min for Group A but inserted subcutaneously to the acupuncture points for Group B as a control. Acupuncture needles were directly inserted perpendicularly into the LI 4 points and PC 6 points for 15 min for Group C. Stimulations of the acupuncture points induced a significant decrease in heart rate (HR), HRV total power (TP), low frequency (LF) power and ratio of low frequency to high frequency (LF/HF), and a significant increase in the HF power in normalized units (NU) during the post stimulation period in fatigue state (P<0.05). Stimulation of acupuncture points resulted in a significant increase both in the LF power and HF power in absolute units (AU) (P<0.05) but no significant change in NU was found during the post stimulation period in non-fatigue state. It was concluded that the modulating effect of acupuncture on heart rate variability not only depended on the points of stimulation such as acupuncture or non-acupuncture points but also on the functional state of the subject, namely whether the subjects are in a state of fatigue or not.

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References

  • Borg G (1982) A category scale with ratio properties for intermodal and interindividual comparisons. Psychophysical judgment and the process of perception. VEB, Berlin, pp 25–34

    Google Scholar 

  • Chao DM, Shen LL, Tjen-A-Looi S, Pitsillides KF, Li P, Longhurst JC (1999) Naloxone reverses inhibitory effect of electro-acupuncture on sympathetic cardiovascular reflex responses. Am J Physiol Heart Circ Physiol 276:H2127–H2134

    CAS  Google Scholar 

  • Fauchier L, Babuty D, Autret ML, Poret P, Cosnay P, Fauchier JP (1998) Influence of duration and hour of recording on spectral measurements of heart rate variability. J Auton Nerv Syst 73:1–6

    Article  CAS  PubMed  Google Scholar 

  • Grandjean E (1979) Fatigue in industry. Br J Intern Med 36:175–186

    CAS  Google Scholar 

  • Haker E, Lundeberg T (1990) Acupuncture treatment in epicondylalgia: a comparative study of two acupuncture techniques. Clin J Pain 6:221–226

    CAS  PubMed  Google Scholar 

  • Haker E, Egekvist H, Bjerring P (2000) Effect of sensory stimulation (acupuncture) on sympathetic and parasympathetic activities in normal subjects. J Auton Nerv Syst 79:52–59

    Article  CAS  PubMed  Google Scholar 

  • Jiao K, Li ZY, Chen M,Wang CT (2004) Effect of different vibration frequencies on heart rate variability and driving fatigue in normal drivers. Int Arch Occup Environ Health 77(3):205:212

    Article  PubMed  Google Scholar 

  • Knardahl S, Elam M, Olausson B, Wallin BG (1998) Sympathetic nerve activity after acupuncture in humans. Pain 75(1):19–25

    Article  CAS  PubMed  Google Scholar 

  • Kobayashi F, Watanabe T, Watanabe M, Akamatsu Y, Tomita T, Nakane T, Furui H, Takeuchi K, Okada A, Ohashi R, Hayano J (2002) Blood pressure and heart rate variability in taxi drivers on long duty schedules. J Occup Health 44(4):214–220

    Article  Google Scholar 

  • Kolzenburg M, Handwerker HO (1994) Differential ability of human cutaneous nociceptors to signal mechanical pain and to produce vasodilatation. J Neurosci 14:1756–1765

    PubMed  Google Scholar 

  • Langford C, Glendon AI (2002) Effects of neuroticism, extraversion, circadian type and age on reported driver stress. Work Stress 16(4):316–334

    Article  Google Scholar 

  • Li ZY, Wang CT (2001) Research on driver fatigue and ergonomics design of automobile. Mech Design Manufact Eng 30(138):12–14

    CAS  Google Scholar 

  • Li ZY, Jiao K, Chen M, Wang CT (2002) Spectral analysis of heart rate variability as a quantitative indicator of driver mental fatigue, 2002-01-0090, SAE 2002. Trans J Passenger Cars Mech Sys 2003:249–254

    Google Scholar 

  • Li ZY, Jiao K, Chen M, Wang CT (2003) Effect of magnitopuncture on sympathetic and parasympathetic activities in normal drivers during simulated driving. Eur J Appl Physiol 88: 404–410

    Google Scholar 

  • Li ZY, Jiao K, Chen M, Wang CT (2004) Reducing the effect of driving fatigue with magnitopuncture. Accid Anal Prev 36(4):501–505

    Article  PubMed  Google Scholar 

  • Liao DP, Barnes RW, Chambless LE, Simpson RJ, Sorlie P, Heiss G (1995) Age, race, and sex differences in autonomic cardiac function measured by spectral analysis of heart rate variability—the ARIC study. Am J Cardiol 76: 906–912

    Article  CAS  PubMed  Google Scholar 

  • Malik M, Camm AJ (1993) Components of heart-rate-variability - what they really mean and what we really measure. American Journal of Cardiology 72(11):821–822

    Article  CAS  PubMed  Google Scholar 

  • Malliani A, Pagani M, Lombardi F (1991) Cardiovascular neural regulation explored in the frequency domain. Circulation 84:482–492

    CAS  PubMed  Google Scholar 

  • Mendelson G (1978) Acupuncture and cholinergic suppression of the withdrawal symptoms: an hypothesis. Br J Addict 73:166–170

    CAS  Google Scholar 

  • Middlekauff HR, Yu JL, Hui KK (2001) Acupuncture effects on reflex responses to mental stress in humans. Am J Physiol Regul Integr Comp Physiol 280:R1462–R1468

    CAS  PubMed  Google Scholar 

  • Milosevic S (1997) Drivers’ fatigue studies. Ergonomics 40(3):381–389

    Article  CAS  PubMed  Google Scholar 

  • Montano N, Gnecchi Ruscone T, Porta A, Lombardi F, Pagani M, Malliani A (1994) Power spectrum analysis of heart rate variability to assess the changes in sympathovagal balance during graded orthostatic tilt. Circulation 90:1826–1831

    CAS  PubMed  Google Scholar 

  • Nishijo K, Mori H, Yosikawa K, Yazawa K (1997) Decreased heart rate by acupuncture stimulation in humans via facilitation of cardiac vagal activity and suppression of cardiac sympathetic nerve. Neurosci Lett 227(3):165–168

    Article  CAS  PubMed  Google Scholar 

  • Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dellorto S, Piccaluga E, Turiel M, Baselli G, Cerutti S, Malliani A (1986) Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympathovagal interaction in man and conscious dog. Circ Res 58:178–193

    Google Scholar 

  • Pagani M, Furlan R, Pizzinelli P, Crivellaro W, Cerutti S, Malliani A (1989) Spectral analysis of R-R and arterial pressure variables to assess sympatho-vagal interaction during mental stress in humans. J Hypertension 7:S14–S15

    CAS  Google Scholar 

  • Pagani M, Lucini D, Mela GS, Langewitz W, Malliani A (1994) Sympathetic overactivity in subjects complaining of unexplained fatigue. Clin Sci 87:655– 661

    CAS  PubMed  Google Scholar 

  • Pagani M, Montano N, Porta A, Malliani A, Abboud FM, Birkett C, Somers VK (1997) Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. Circulation 95:1441–1448

    CAS  PubMed  Google Scholar 

  • Raggantt PTF (1991) Work stress among long-distance coach drivers: a survey and correlation study. J Organ Behav 12:565–579

    Google Scholar 

  • Sato A, Sato Y, Suzuki A, Uchida S (1996) Reflex modulation of catecholamine secretion and adrenal sympathetic nerve activity by acupuncture-like stimulation in anesthetized rat. Jpn J Physiol 46:411– 421

    Article  CAS  PubMed  Google Scholar 

  • Streitberger K, Kleinhenz K (1998) Introducing a placebo needle into acupuncture research. Lancet 352:364–365

    Article  CAS  PubMed  Google Scholar 

  • Sugiyama Y, Xue Y, Mano T (1995) Transient increase in human muscle sympathetic nerve activity during manual acupuncture. Jpn J Physiol 45:337–345

    Article  CAS  PubMed  Google Scholar 

  • Suter B, Kistler A (1994) Does acupuncture influence the cardiovascuacupuncture system via the central nervous system?. Schweiz Med Wochenschr 124:36–38

    Google Scholar 

  • Task Force of the European Society of Cardiology, the North American Society of Pacing Electrophysiology (1996) Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Circulation 93:1043–1065

    PubMed  Google Scholar 

  • Wang JD, Kuo TBJ, Yang CCH (2002) An alternative method to enhance vagal activities and suppress sympathetic activities in humans. Auton Neurosci-Basic Clin 100(1–2):90–95

    Article  CAS  Google Scholar 

  • Wildervank C, Mulder G, Michon J (1978) Mapping mental load in car driving. Ergonomics 21: 225–229

    PubMed  Google Scholar 

  • Williams R, Horvath S (1995) Recovery from dynamic exercise. Am J Physiol Heart Circ Physiol 268:H2311–H2320

    CAS  Google Scholar 

  • Yao T, Andersson S, Thore P (1982) Long-lasting cardiovascular depression induced by acupuncture-like stimulation of the sciatic nerve in unanaesthetized spontaneously hypertensive rats. Brain Res 240:77–85

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

The authors would like to acknowledge Takashimaya Nippatsu Kogyo Co., Ltd. for funding this research and all the participants at Shanghai Jiaotong University and acupuncturist (Qi SH) at Zhongshan hospital for spending time and effort to help us in this study.

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Authors and Affiliations

  1. Jockey Club Rehabilitation Engineering Centre, The Hong Kong Polytechnic University, Kowloon, Hong Kong, P.R. China

    Zengyong Li, Arthur F. T. Mak & Daniel H. K. Chow

  2. School of Mechanical Engineering, Shandong University, Jinan, P.R. China

    Zengyong Li

  3. School of Mechanical Engineering, Shanghai Jiaotong University, Shanghai, P.R. China

    Chengtao Wang

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  1. Zengyong Li
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  2. Chengtao Wang
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  3. Arthur F. T. Mak
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  4. Daniel H. K. Chow
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Correspondence to Zengyong Li.

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Li, Z., Wang, C., Mak, A.F.T. et al. Effects of acupuncture on heart rate variability in normal subjects under fatigue and non-fatigue state. Eur J Appl Physiol 94, 633–640 (2005). https://doi.org/10.1007/s00421-005-1362-z

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  • DOI: https://doi.org/10.1007/s00421-005-1362-z

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