Abstract
Purpose
Occupational exposure to combustion products rich in polycyclic aromatic hydrocarbons and particles is associated with an increased risk of lung cancer. This study aimed to evaluate whether the risk depended on the age at which the individuals were exposed.
Methods
Data from 1042 lung cancer cases and 2364 frequency-matched population controls selected from all men aged 40–75 years residing in Stockholm County, Sweden, at any time between 1985 and 1990, included detailed questionnaire information on occupational, residential, and smoking history. Occupational exposures were assessed by an occupational hygienist, and exposure to air pollution from road traffic was estimated based on dispersion models.
Results
We found that individuals exposed to combustion products in their twenties were at higher risk than those never exposed (adjusted OR = 1.46; 95 % CI 1.02, 2.10). The association was still evident after adjusting for a number of potential confounders, including lifetime cumulative exposure and latency. No clear association was found in those exposed at older ages.
Conclusions
Exposure to combustion products at a young age was associated with elevated risk of lung cancer. Exposure-reduction programs should be aware of the susceptibility of the younger employees.
Similar content being viewed by others
Abbreviations
- CI:
-
Confidence interval
- n :
-
Count
- OR:
-
Odds ratio
- PAH:
-
Polycyclic aromatic hydrocarbons
- μg:
-
Micrograms
References
Bellander T, Berglind N, Gustavsson P, Jonson T, Nyberg F, Pershagen G, Järup L (2001) Using geographic information systems to assess individual historical exposure to air pollution from traffic and house heating in Stockholm. Environ Health Perspect 109(6):633–639
Blair A, Stewart P, Lubin JH, Forastiere F (2007) Methodological issues regarding confounding and exposure misclassification in epidemiological studies of occupational exposures. Am J Ind Med 50(3):199–207
Boerrigter ME, Wei JY, Vijg J (1995) Induction and repair of benzo[a]pyrene-DNA adducts in C57BL/6 and BALB/c mice: association with aging and longevity. Mech Ageing Dev 82(1):31–50 Review
Boffetta P, Jourenkova N, Gustavsson P (1997) Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. Cancer Causes Control 8(3):444–472
Gustavsson P, Jakobsson R, Nyberg F, Pershagen G, Järup L, Schéele P (2000) Occupational exposure and lung cancer risk: a population-based case-referent study in Sweden. Am J Epidemiol 152:32–40
Hegmann KT, Fraser AM, Keaney RP, Moser SE, Nilasena DS, Sedlars M, Higham-Gren L, Lyon JL (1993) The effect of age at smoking initiation on lung cancer risk. Epidemiology 4(5):444–448
International Agency for Research on Cancer (2012) IARC monographs on the evaluation of carcinogenic risks to humans. In: A review of human carcinogens—part F: chemical agents and related occupations, vol 100F. International Agency for Research on Cancer, Lyon
Jung S (1996) Quasi-likelihood for median regression models. J Am Stat Assoc 91:251–257
Kauppinen T, Toikkanen J, Pedersen D, Young R, Ahrens W, Boffetta P, Hansen J, Kromhout H, Maqueda Blasco J, Mirabelli D, de la Orden-Rivera V, Pannett B, Plato N, Savela A, Vincent R, Kogevinas M (2000) Occupational exposure to carcinogens in the European Union. Occup Environ Med 57(1):10–18
Lewné M, Nise G, Lind ML, Gustavsson P (2006) Exposure to particles and nitrogen dioxide among taxi, bus and lorry drivers. Int Arch Occup Environ Health 79(3):220–226
Lewné M, Plato N, Gustavsson P (2007) Exposure to particles, elemental carbon and nitrogen dioxide in workers exposed to motor exhaust. Ann Occup Hyg 51(8):693–701
Lewné M, Plato N, Bellander T, Alderling M, Gustavsson P (2011) Occupational exposure to motor exhaust in Stockholm, Sweden—different grouping strategies using variability in NO2 to create homogenous groups. Int J Hyg Environ Health 214(1):47–52
Lipsitz SR, Fitzmaurice GM, Molenberghs G, Zhao LP (1997) Quantile regression methods for longitudinal data with drop-outs: application to CD4 cell counts of patients infected with the human immunodeficiency virus. J R Stat Soc Ser C Appl Stat 46:463–476
Nordling E, Berglind N, Melén E, Emenius G, Hallberg J, Nyberg F, Pershagen G, Svartengren M, Wickman M, Bellander T (2008) Traffic-related air pollution and childhood respiratory symptoms, function and allergies. Epidemiology 19:401–408
Nyberg F, Gustavsson P, Järup L, Bellander T, Berglind N, Jakobsson R, Pershagen G (2000) Urban air pollution and lung cancer in Stockholm. Epidemiology 11:587–595
Papadopoulos A, Guida F, Cénée S, Cyr D, Schmaus A, Radoï L, Paget-Bailly S, Carton M, Tarnaud C, Menvielle G, Delafosse P, Molinié F, Luce D, Stücker I (2011) Cigarette smoking and lung cancer in women: results of the French ICARE case–control study. Lung Cancer 74(3):369–377
Rosenlund M, Berglind N, Pershagen G, Hallqvist J, Jonson T, Bellander T (2006) Long-term exposure to urban air pollution and myocardial infarction. Epidemiology 18:383–390
Talaska G, Thoroman J, Schuman B, Käfferlein HU (2014) Biomarkers of polycyclic aromatic hydrocarbon exposure in European coke oven workers. Toxicol Lett 231(2):213–216
Wiencke JK, Thurston SW, Kelsey KT, Varkonyi A, Wain JC, Mark EJ, Christiani DC (1999) Early age at smoking initiation and tobacco carcinogen DNA damage in the lung. J Natl Cancer Inst 91(7):614–619
Wolff MS, Herbert R, Marcus M, Rivera M, Landrigan PJ, Andrews LR (1989) Polycyclic aromatic hydrocarbon (PAH) residues on skin in relation to air levels among roofers. Arch Environ Health 44(3):157–163
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Bottai, M., Selander, J., Pershagen, G. et al. Age at occupational exposure to combustion products and lung cancer risk among men in Stockholm, Sweden. Int Arch Occup Environ Health 89, 271–275 (2016). https://doi.org/10.1007/s00420-015-1070-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00420-015-1070-x