International Archives of Occupational and Environmental Health

, Volume 87, Issue 5, pp 455–462

Lack of association between occupational exposure to diesel exhaust and risk of pancreatic cancer: a systematic evaluation of available data

Authors

    • Mount Sinai School of Medicine
    • International Prevention Research Institute
Review Article

DOI: 10.1007/s00420-013-0892-7

Cite this article as:
Boffetta, P. Int Arch Occup Environ Health (2014) 87: 455. doi:10.1007/s00420-013-0892-7
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Abstract

Purpose

To review epidemiologic studies on risk of pancreatic cancer and occupational exposure to diesel exhaust.

Methods

A literature search was conducted, and data were abstracted in a systematic fashion. Comparable results were combined using a random-effects meta-analysis.

Results

Twenty-six studies were included in the review, including five studies based on routine statistics, 11 case–control studies [meta-relative risk (RR) of three estimates for diesel exhaust exposure 0.9; 95 % confidence interval (CI) 0.5, 1.6] and ten cohort studies (meta-RR of their results: 1.03; 95 % CI 0.93, 1.13). Few studies reported results according to duration of exposure or other quantitative measures; no consistent pattern emerged.

Conclusions

The overall evidence from studies on occupational exposure to diesel exhaust and risk of pancreatic cancer leads to the conclusion of the absence of such association.

Keywords

Diesel exhaustPancreatic cancerEpidemiology

Copyright information

© Springer-Verlag Berlin Heidelberg 2013