Review Article

International Archives of Occupational and Environmental Health

, Volume 87, Issue 5, pp 455-462

First online:

Lack of association between occupational exposure to diesel exhaust and risk of pancreatic cancer: a systematic evaluation of available data

  • Paolo BoffettaAffiliated withMount Sinai School of MedicineInternational Prevention Research Institute Email author 

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To review epidemiologic studies on risk of pancreatic cancer and occupational exposure to diesel exhaust.


A literature search was conducted, and data were abstracted in a systematic fashion. Comparable results were combined using a random-effects meta-analysis.


Twenty-six studies were included in the review, including five studies based on routine statistics, 11 case–control studies [meta-relative risk (RR) of three estimates for diesel exhaust exposure 0.9; 95 % confidence interval (CI) 0.5, 1.6] and ten cohort studies (meta-RR of their results: 1.03; 95 % CI 0.93, 1.13). Few studies reported results according to duration of exposure or other quantitative measures; no consistent pattern emerged.


The overall evidence from studies on occupational exposure to diesel exhaust and risk of pancreatic cancer leads to the conclusion of the absence of such association.


Diesel exhaust Pancreatic cancer Epidemiology