Original Paper

Histochemistry and Cell Biology

, Volume 131, Issue 6, pp 703-711

Human mast cells express leptin and leptin receptors

  • Jasmien TaildemanAffiliated withDepartment of Pathology, Ghent University Hospital, Ghent University
  • , Claudina A. Pérez-NovoAffiliated withDepartment of Otorhinolaryngology, Ghent University Hospital, Ghent University
  • , Isabelle RottiersAffiliated withDepartment of Pathology, Ghent University Hospital, Ghent University
  • , Liesbeth FerdinandeAffiliated withDepartment of Pathology, Ghent University Hospital, Ghent University
  • , Anouk WaeytensAffiliated withDepartment of Pathology, Ghent University Hospital, Ghent University
  • , Veerle De ColvenaerAffiliated withDepartment of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University
  • , Claus BachertAffiliated withDepartment of Otorhinolaryngology, Ghent University Hospital, Ghent University
  • , Pieter DemetterAffiliated withDepartment of Pathology, Erasme University Hospital, Université Libre de Bruxelles
  • , Wim WaelputAffiliated withDepartment of Pathology, Antwerp University Hospital
    • , Katleen BraetAffiliated withSchool of Molecular and Microbial Sciences, University of Queensland
    • , Claude A. CuvelierAffiliated withDepartment of Pathology, Ghent University Hospital, Ghent University Email author 

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Abstract

Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor which is expressed by many immune cells. However, there are no data about leptin receptor expression in mast cells. Immunohistochemical and immunofluorescent double stainings showed the expression of leptin and leptin receptors in mast cells in human skin and several parts of the respiratory, gastrointestinal and urogenital tract. Leptin was expressed in mast cells expressing the classification marker chymase, whereas a variable expression was observed in tryptase positive mast cells. For leptin receptors, the expression pattern was tissue dependent and not related to tryptase or chymase expression. Our results demonstrate the expression of leptin and leptin receptors on mast cells, suggesting paracrine and/or autocrine immunomodulatory effects of leptin on mast cells.

Keywords

Leptin Leptin receptor Mast cell Mast cell phenotypes