Histochemistry and Cell Biology

, Volume 131, Issue 6, pp 703–711

Human mast cells express leptin and leptin receptors

  • Jasmien Taildeman
  • Claudina A. Pérez-Novo
  • Isabelle Rottiers
  • Liesbeth Ferdinande
  • Anouk Waeytens
  • Veerle De Colvenaer
  • Claus Bachert
  • Pieter Demetter
  • Wim Waelput
  • Katleen Braet
  • Claude A. Cuvelier
Original Paper

DOI: 10.1007/s00418-009-0575-3

Cite this article as:
Taildeman, J., Pérez-Novo, C.A., Rottiers, I. et al. Histochem Cell Biol (2009) 131: 703. doi:10.1007/s00418-009-0575-3

Abstract

Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor which is expressed by many immune cells. However, there are no data about leptin receptor expression in mast cells. Immunohistochemical and immunofluorescent double stainings showed the expression of leptin and leptin receptors in mast cells in human skin and several parts of the respiratory, gastrointestinal and urogenital tract. Leptin was expressed in mast cells expressing the classification marker chymase, whereas a variable expression was observed in tryptase positive mast cells. For leptin receptors, the expression pattern was tissue dependent and not related to tryptase or chymase expression. Our results demonstrate the expression of leptin and leptin receptors on mast cells, suggesting paracrine and/or autocrine immunomodulatory effects of leptin on mast cells.

Keywords

LeptinLeptin receptorMast cellMast cell phenotypes

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Jasmien Taildeman
    • 1
  • Claudina A. Pérez-Novo
    • 2
  • Isabelle Rottiers
    • 1
  • Liesbeth Ferdinande
    • 1
  • Anouk Waeytens
    • 1
  • Veerle De Colvenaer
    • 3
  • Claus Bachert
    • 2
  • Pieter Demetter
    • 4
  • Wim Waelput
    • 5
  • Katleen Braet
    • 6
  • Claude A. Cuvelier
    • 1
  1. 1.Department of PathologyGhent University Hospital, Ghent UniversityGhentBelgium
  2. 2.Department of OtorhinolaryngologyGhent University Hospital, Ghent UniversityGhentBelgium
  3. 3.Department of Clinical Chemistry, Microbiology and ImmunologyGhent University Hospital, Ghent UniversityGhentBelgium
  4. 4.Department of PathologyErasme University Hospital, Université Libre de BruxellesBrusselsBelgium
  5. 5.Department of PathologyAntwerp University HospitalAntwerpBelgium
  6. 6.School of Molecular and Microbial SciencesUniversity of QueenslandBrisbaneAustralia