Abstract
Purpose
To analyze the structures of schisis in eyes with hereditary juvenile retinoschisis using en-face optical coherence tomography (OCT) imaging.
Methods
In this retrospective observational study, we reviewed the medical records of patients with hereditary juvenile retinoschisis who underwent comprehensive ophthalmic examinations including swept-source OCT.
Results
OCT images were obtained from 16 eyes of nine boys (mean age ± standard deviation, 10.6 ± 4.0 years). The horizontal OCT images at the fovea showed inner nuclear layer (INL) schisis in one eye (6.3 %), ganglion cell layer (GCL) and INL schisis in 12 eyes (75.0 %), INL and outer plexiform layer (OPL) schisis in two eyes (12.5 %), and GCL, INL, and OPL schisis in one eye (6.3 %). En-face OCT images showed characteristic schisis patterns in each retinal layer, which were represented by multiple hyporeflective holes in the parafoveal region in the GCL, a spoke-like pattern in the foveal region, a reticular pattern in the parafoveal region in the INL, and multiple hyporeflective polygonal cavities with partitions in the OPL.
Conclusions
Our results using en-face OCT imaging clarified different patterns of schisis formation among the GCL, INL, and OPL, which lead to further recognition of structure in hereditary juvenile retinoschisis.
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Acknowledgments
We thank the patients for participating in this study. This work was supported by grants from the Ministry of Health, Labour, and Welfare (H24-Nanchi-Ippan-031) and the National Centre for Child Health and Development 25-7.
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The Institutional Review Board of the National Center for Child Health and Development approved this retrospective observational case series, which adhered to the tenets of the Declaration of Helsinki.
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Supplementary Fig. 1
Pairs of horizontal optical coherence tomography (OCT) images of each retinal layer from 512 A-scans × 256 B-scans in a 3 × 3-millimeter square. a A randomly selected pair of upper and lower horizontal OCT images corresponding to the holes in the ganglion cell layer (GCL) on en-face OCT clearly show several schisis cavities in the GCL, while the B-scan images do not detect a round expanding schisis cavity (right eye of case 5). b A randomly selected pair of upper and lower horizontal OCT images corresponding to the reticular pattern in the inner nuclear layer (INL) on en-face OCT show similar structures (right eye of case 3). c A randomly selected pair of upper and lower horizontal OCT images corresponding to a spoke-wheel pattern in the INL on en-face OCT show similar structures (right eye of case 6). d A randomly selected pair of upper and lower horizontal OCT images corresponding to polygonal hyporeflective cavities with hyperreflective partitions in the outer plexiform layer on en-face OCT show similar structures (right eye of case 8). a–d In each column, yellow dashed lines in the upper panels indicate the position at which the B-scan images in the middle and the lower panels are obtained. The orange arrows in the upper panels indicating the cavity in each en-face OCT image correspond to the orange arrows in the middle panels indicating the cavity in each B-scan image. The yellow arrows in the upper panels indicating the cavity in each en-face OCT image correspond to the yellow arrows in the lower panels indicating the cavity in each B-scan image. (GIF 99 kb)
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Yoshida-Uemura, T., Katagiri, S., Yokoi, T. et al. Different foveal schisis patterns in each retinal layer in eyes with hereditary juvenile retinoschisis evaluated by en-face optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 255, 719–723 (2017). https://doi.org/10.1007/s00417-016-3552-2
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DOI: https://doi.org/10.1007/s00417-016-3552-2