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Relationship between mean platelet volume and retinopathy of prematurity

  • Pediatrics
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

We aimed to investigate the association between mean platelet volume (MPV) and the occurrence of type 1 retinopathy of prematurity (ROP).

Materials and methods

This was a retrospective case–control study. Cases with ROP required laser surgery; controls developed no ROP or stage 1 ROP. Most recent peripheral blood platelet indices before laser (case) and matched age (control) were abstracted. Student's t-test and multivariate logistic regression analysis were used.

Results

A significant difference was found in MPV values between infants with ROP and control groups (10.76 ± 1.27 fl, 10.04 ± 0.91 fl, p = 0.0001). No significant differences were found in the mean platelet counts or MPV/Platelet counts between the two groups (p = 0.4151, p = 0.1460, respectively). There was a 1.94-fold increase in the risk of retinopathy of prematurity (OR:1.94; p = 0.005) as the MPV value increased.

Conclusions

Elevated MPV is associated with the occurrence of type 1 ROP. A hypothesis is presented concerning the role of platelets as sequester and deliverer angiogenesis regulators during the neovascularization phase of ROP.

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References

  1. Hartnett ME, Penn JS (2012) Mechanisms and management of retinopathy of prematurity. N Engl J Med 367:2515–2526. doi:10.1056/Nejmra1208129

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Gilbert C (2008) Retinopathy of prematurity: a global perspective of the epidemics, population of babies at risk and implications for control. Early Hum Dev 84:77–82. doi:10.1016/j.earlhumdev.2007.11.009

    Article  PubMed  Google Scholar 

  3. Rivera JC, Sapieha P, Joyal JS, Duhamel F, Shao Z, Sitaras N, Picard E, Zhou E, Lachapelle P, Chemtob S (2011) Understanding retinopathy of prematurity: update on pathogenesis. Neonatology 100:343–353. doi:10.1159/000330174

    Article  CAS  PubMed  Google Scholar 

  4. Sapieha P, Joyal JS, Rivera JC, Kermorvant-Duchemin E, Sennlaub F, Hardy P, Lachapelle P, Chemtob S (2010) Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life. J Clin Invest 120:3022–3032. doi:10.1172/jci42142

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Palmblad J (2009) Platelets and angiogenesis: novel aspects. Expert Rev Hematol 2:1–2. doi:10.1586/17474086.2.1.1

    Article  PubMed  Google Scholar 

  6. Patzelt J, Langer HF (2012) Platelets in angiogenesis. Curr Vasc Pharmacol 10:570–577

    Article  CAS  PubMed  Google Scholar 

  7. Italiano JE, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S, Folkman J, Klement GL (2008) Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 111:1227–1233. doi:10.1182/blood-2007-09-113837

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, Mohler ER, Reilly MP, Berger JS (2010) Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 8:148–156. doi:10.1111/j.1538-7836.2009.03584.x

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. Early Treatment For Retinopathy Of Prematurity Cooperative G (2003) Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 121:1684–1694. doi:10.1001/archopht.121.12.1684

    Article  Google Scholar 

  10. Hellstrom A, Smith LE, Dammann O (2013) Retinopathy of prematurity. Lancet 382:1445–1457. doi:10.1016/s0140-6736(13)60178-6

    Article  PubMed Central  PubMed  Google Scholar 

  11. Chen J, Smith LE (2007) Retinopathy of prematurity. Angiogenesis 10:133–140. doi:10.1007/s10456-007-9066-0

    Article  PubMed  Google Scholar 

  12. Smith LE (2004) Pathogenesis of retinopathy of prematurity. Growth Hormon Igf Res 14(Suppl A):S140–S144. doi:10.1016/j.ghir.2004.03.030

    Article  CAS  Google Scholar 

  13. Cekmez F, Tanju IA, Canpolat FE, Aydinoz S, Aydemir G, Karademir F, Sarici SU (2013) Mean platelet volume in very preterm infants: a predictor of morbidities? Eur Rev Med Pharmacol 17:134–137

    CAS  Google Scholar 

  14. Palmer EA, Flynn JT, Hardy RJ, Phelps DL, Phillips CL, Schaffer DB, Tung B (1991) Incidence and early course of retinopathy of prematurity. The Cryotherapy for Retinopathy of Prematurity Cooperative Group. Ophthalmology 98:1628–1640

    Article  CAS  PubMed  Google Scholar 

  15. Vinekar A, Hegde K, Gilbert C, Braganza S, Pradeep M, Shetty R, Shetty KB (2010) Do platelets have a role in the pathogenesis of aggressive posterior retinopathy of prematurity? Retina 30:S20–S23. doi:10.1097/IAE.0b013e3181cafc30

    Article  PubMed  Google Scholar 

  16. Jensen AK, Ying GS, Huang JY, Karp K, Quinn GE, Binenbaum G (2011) Thrombocytopenia and retinopathy of prematurity. J Aapos 15:447–450. doi:10.1016/j.jaapos.2011.07.006

    Article  Google Scholar 

  17. Klement GL, Yip TT, Cassiola F, Kikuchi L, Cervi D, Podust V, Italiano JE, Wheatley E, Abou-Slaybi A, Bender E, Almog N, Kieran MW, Folkman J (2009) Platelets actively sequester angiogenesis regulators. Blood 113:2835–2842. doi:10.1182/blood-2008-06-159541

    Article  CAS  PubMed  Google Scholar 

  18. Leader A, Pereg D, Lishner M (2012) Are platelet volume indices of clinical use? A multidisciplinary review. Ann Med 44:805–816. doi:10.3109/07853890.2011.653391

    Article  PubMed  Google Scholar 

  19. Lance MD, Sloep M, Henskens YM, Marcus MA (2012) Mean platelet volume as a diagnostic marker for cardiovascular disease: drawbacks of preanalytical conditions and measuring techniques. Clin Appl Thromb Hemost 18:561–568. doi:10.1177/1076029612458147

    Article  PubMed  Google Scholar 

  20. Ayhan Tuzcu E, Arica S, Ilhan N, Daglioglu M, Coskun M, Ilhan O, Ustun I (2013) Relationship between mean platelet volume and retinopathy in patients with type 2 diabetes mellitus. Graefes Arch Clin Exp 252:237–240. doi:10.1007/s00417-013-2444-y

    Article  Google Scholar 

  21. Zhong ZL, Han M, Chen S (2011) Risk factors associated with retinal neovascularization of diabetic retinopathy in type 2 diabetes mellitus. Int J Ophthalmol 4:182–185. doi:10.3980/j.issn. 2222-3959.2011.02.15

    PubMed Central  PubMed  Google Scholar 

  22. Tremolada G, Del Turco C, Lattanzio R, Maestroni S, Maestroni A, Bandello F, Zerbini G (2012) The role of angiogenesis in the development of proliferative diabetic retinopathy: impact of intravitreal anti-VEGF treatment. Exp Diabetes Res 2012:728325. doi:10.1155/2012/728325

    Article  PubMed Central  PubMed  Google Scholar 

  23. Azab B, Torbey E, Singh J, Akerman M, Khoueiry G, McGinn JT, Widmann WD, Lafferty J (2011) Mean platelet volume/platelet count ratio as a predictor of long-term mortality after non-ST-elevation myocardial infarction. Platelets 22:557–566. doi:10.3109/09537104.2011.584086

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This work was financed by the Scientific and Technological Developing Scheme of Jilin Province (Grants 20130206060SF).

Conflict of interest

The authors declare no funding and no competing interest in the preparation of this manuscript. The authors have no financial interest in the research.

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Authors and Affiliations

  1. Department of Ophthalmology, the First Hospital of Jilin University, No.71 Xin Min Road, Changchun, 130021, Jilin, China

    Yuan Tao, Yu Dong, Cheng-wei Lu, Wei Yang & Qian Li

Authors
  1. Yuan Tao
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  2. Yu Dong
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  3. Cheng-wei Lu
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  4. Wei Yang
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  5. Qian Li
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Correspondence to Yu Dong.

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Tao, Y., Dong, Y., Lu, Cw. et al. Relationship between mean platelet volume and retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol 253, 1791–1794 (2015). https://doi.org/10.1007/s00417-015-2972-8

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  • DOI: https://doi.org/10.1007/s00417-015-2972-8

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