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Retinal vascular caliber between eyes with asymmetric glaucoma

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To compare differences in retinal arterial and venular caliber (RAC and RVC respectively) between fellow eyes with glaucoma of asymmetric severity.

Methods

We included subjects with bilateral primary glaucoma that had vertical cup–disc ratios (VCDR) >0.2 between both eyes, or visual field (VF) mean deviation (MD) >6.0 decibels (dB) between both eyes.

Results

Among 158 subjects, the average RAC in glaucoma eyes was 131.5 ± 17.8 μm vs 141.6 ± 18.8 μm in fellow eyes with mild disease (p < 0.001). RVCs in glaucoma eyes were 201.0 ± 21.4 μm vs 211.7 ± 25.3 μm in fellow eyes with mild disease (p < 0.001). This relationship held in clustered linear regression models adjusted for age, gender, vascular risk factors, visual acuity, axial length, and intraocular pressure, with RVCs narrower in eyes with worse disease vs mild disease. Eyes with worse disease had greater VCDR (0.9 ± 0.1 vs 0.7 ± 0.1, p < 0.001), and worse VF MD (−18.5 ± 8.6 vs −6.6 ± 5.6, p < 0.001).

Conclusion

In glaucoma with asymmetric severity between fellow eyes, retinal vascular caliber is less in the eye with more severe disease.

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Grant Support

This study was funded by the National Medical Research Council of Singapore grant no. NMRC/ NIG/ 0061/2009.

Clinical Trial

Retinal Microvascular Changes and Asian Glaucoma Subtypes: Understanding Early Vascular Mechanisms in Asian Glaucoma — Principal Investigator: Daniel Su Hsien Wen, Singapore Eye Research Institute.

Conflict of interest

All the authors of this manuscript have declared that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Singapore Eye Research Institute, Singapore, Singapore

    John Mark S. De Leon, Carol Y. Cheung, Tien-Yin Wong, Xiang Li, Haslina Hamzah, Tin Aung & Daniel Hsien-Wen SU

  2. Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, 168751, Singapore

    Tien-Yin Wong, Tin Aung & Daniel Hsien-Wen SU

  3. National University of Singapore, Singapore, Singapore

    Tien-Yin Wong & Tin Aung

  4. Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore

    Xiang Li

Authors
  1. John Mark S. De Leon
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  2. Carol Y. Cheung
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  3. Tien-Yin Wong
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  4. Xiang Li
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  5. Haslina Hamzah
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  6. Tin Aung
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  7. Daniel Hsien-Wen SU
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Corresponding author

Correspondence to Daniel Hsien-Wen SU.

Additional information

All the authors have full control of all primary data, and they agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review their data upon request.

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De Leon, J.M.S., Cheung, C.Y., Wong, TY. et al. Retinal vascular caliber between eyes with asymmetric glaucoma. Graefes Arch Clin Exp Ophthalmol 253, 583–589 (2015). https://doi.org/10.1007/s00417-014-2895-9

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  • DOI: https://doi.org/10.1007/s00417-014-2895-9

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