Retinal Disorders

Graefe's Archive for Clinical and Experimental Ophthalmology

, Volume 252, Issue 2, pp 219-226

Retinal outer layer thickness increases after vitrectomy for epiretinal membrane, and visual improvement positively correlates with photoreceptor outer segment length

  • Yuki HashimotoAffiliated withDepartment of Ophthalmology, Hokkaido University Graduate School of Medicine
  • , Wataru SaitoAffiliated withDepartment of Ophthalmology, Hokkaido University Graduate School of MedicineDepartment of Ocular Circulation and Metabolism, Hokkaido University Graduate School of Medicine Email author 
  • , Michiyuki SaitoAffiliated withDepartment of Ophthalmology, Hokkaido University Graduate School of Medicine
  • , Kiriko HirookaAffiliated withDepartment of Ophthalmology, Hokkaido University Graduate School of Medicine
  • , Akio FujiyaAffiliated withDepartment of Ophthalmology, Hokkaido University Graduate School of Medicine
  • , Chikako YoshizawaAffiliated withDepartment of Ophthalmology, Hokkaido University Graduate School of Medicine
  • , Kousuke NodaAffiliated withDepartment of Ophthalmology, Hokkaido University Graduate School of MedicineDepartment of Ocular Circulation and Metabolism, Hokkaido University Graduate School of Medicine
  • , Susumu IshidaAffiliated withDepartment of Ophthalmology, Hokkaido University Graduate School of MedicineDepartment of Ocular Circulation and Metabolism, Hokkaido University Graduate School of Medicine

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Abstract

Purpose

To investigate postoperative thickness changes in the retinal layers in eyes with epiretinal membrane (ERM). Correlations between these changes and visual outcomes were also examined.

Methods

Retrospective review of 25 eyes (24 patients) that had undergone pars plana vitrectomy for ERM and had a postoperative follow-up period ≥6 months. Optical coherence tomography (6 × 6 mm macular thickness map) was used to measure mean thickness of the inner and outer retinal layers 1 week and 1, 3, and 6 months following surgery. Photoreceptor outer segment (PROS) length was evaluated manually, and used to assess the association between best-corrected visual acuity (BCVA) and retinal layer thickness at the fovea.

Results

At 1 week and 1, 3, and 6 months, retinal layer thickness was 388, 377, 362, and 352 μm for the whole layer; 133, 115, 107, and 101 μm for the inner layer; 138, 145, 147, and 148 μm for the outer layer; and 28, 35, 36, and 40 μm for the PROS length, respectively. In comparison to 1-week data, the inner layers were significantly thinner at 1 month and later, as was the thickness of the entire retina. Outer layer thickness and PROS length were also significantly thicker at these time points. Six months following surgery, BCVA was significantly correlated with an elongated PROS length (R = 0.49, P = 0.01).

Conclusion

Retinal outer layer thickness significantly increased following pars plana vitrectomy for ERM. Visual improvement was positively correlated with PROS length recovery.

Keywords

Cone outer segment tip Epiretinal membrane External limiting membrane Optical coherence tomography Photoreceptor inner segment and outer segment junction Photoreceptor outer segment length Retinal thickness