Skip to main content

Advertisement

Log in

Pulse-wave analysis of optic nerve head circulation is significantly correlated with brachial–ankle pulse-wave velocity, carotid intima–media thickness, and age

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

To determine whether there is a significant correlation between the pulse-wave analysis in the optic nerve head circulation determined by laser speckle flowgraphy (LSFG), and brachial–ankle pulse wave velocity (baPVW), carotid intima–media thickness (IMT), and age.

Methods

Thirty-three patients who visited the Vascular Function Section in our hospital were included. Age was 57.3 ± 12.6 years, with a range from 29 to 80 years. baPVW, carotid IMT, and pulse wave analysis in optic nerve head circulation using LSFG were conducted on subjects, and this parameter is named blowout time (BOT). The following items were analyzed as other systemic parameters: age, blood pressure, pulse pressure, heart rate, body mass index, and mean arterial blood pressure; other ocular parameters were intraocular pressure and ocular perfusion pressure. Pearson’s correlation coefficients were used to determine the relationship between the BOT, baPWV, IMT, age, and other parameters. In addition, multiple regression analysis was used to determine independent factors for age.

Results

BOT was significantly correlated with age (r = −0.85, P <0.0001), pulse pressure (r = −0.36, P = 0.04), baPWV (r = −0.72, P <0.0001), and IMT (r = −0.64, P < 0.0001). The result of multiple regression analysis showed that baPWV (odds ratio = 0.93, 95% confidence interval = 0.03–1.82 P = 0.04) and BOT (−2.26, −3.27  to −1.26, <0.0001) were independent contribution factors to age.

Conclusions

Our results confirmed measurements of BOT in the optic nerve head can be a useful method for determinin g whether early atherosclerotic changes are present in the optic nerve head circulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Pinto E (2007) Blood pressure and ageing. Postgrad Med J 83:109–114

    Article  PubMed  Google Scholar 

  2. Mitchell P, Smith W, Chang A (1996) Prevalence and associations of retinal vein occlusion in Australia. The Blue Mountains Eye Study. Arch Ophthalmol 114:1243–1247

    Article  PubMed  CAS  Google Scholar 

  3. Yasuda M, Kiyohara Y, Arakawa S, Hata Y, Yonemoto K, Doi Y, Iida M, Ishibashi T (2010) Prevalence and systemic risk factors for retinal vein occlusion in a general Japanese population: the Hisayama study. Invest Ophthalmol Vis Sci 51:3205–3209

    Article  PubMed  Google Scholar 

  4. Hayreh SS, Zimmerman MB, Podhajsky P (1994) Incidence of various types of retinal vein occlusion and their recurrence and demographic characteristics. Am J Ophthalmol 117:429–441

    PubMed  CAS  Google Scholar 

  5. Miyazaki M, Nakamura H, Kubo M, Kiyohara Y, Oshima Y, Ishibashi T, Nose Y (2003) Risk factors for age related maculopathy in a Japanese population: the Hisayama study. Br J Ophthalmol 87:469–472

    Article  PubMed  CAS  Google Scholar 

  6. Miyazaki M, Kiyohara Y, Yoshida A, Iida M, Nose Y, Ishibashi T (2005) The 5-year incidence and risk factors for age-related maculopathy in a general Japanese population: the Hisayama study. Invest Ophthalmol Vis Sci 46:1907–1910

    Article  PubMed  Google Scholar 

  7. Kaderli AA, Kaderli B, Gullulu S, Avci R (2010) Impaired aortic stiffness and pulse wave velocity in patients with branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 248:369–374

    Article  PubMed  Google Scholar 

  8. Sato E, Feke GT, Appelbaum EY, Menke MN, Trempe CL, McMeel JW (2006) Association between systemic arterial stiffness and age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 244:963–971

    Article  PubMed  Google Scholar 

  9. Klein R, Klein BE, Knudtson MD, Cotch MF, Wong TY, Liu K, Burke GL, Saad MF, Jacobs DR Jr, Sharrett AR (2007) Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of Atherosclerosis. Arch Ophthalmol 125:534–543

    Article  PubMed  CAS  Google Scholar 

  10. Lehmann ED (1999) Clinical value of aortic pulse-wave velocity measurement. Lancet 354:528–529

    Article  PubMed  CAS  Google Scholar 

  11. Asmar R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac AM, Target R, Levy BI (1995) Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension 26:485–490

    Article  PubMed  CAS  Google Scholar 

  12. Suzuki E, Kashiwagi A, Nishio Y, Egawa K, Shimizu S, Maegawa H, Haneda M, Yasuda H, Morikawa S, Inubushi T, Kikkawa R (2001) Increased arterial wall stiffness limits flow volume in the lower extremities in type 2 diabetic patients. Diabetes Care 24:2107–2114

    Article  PubMed  CAS  Google Scholar 

  13. Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K, Koji Y, Hori S, Yamamoto Y (2002) Validity, reproducibility, and clinical significance of noninvasive brachial–ankle pulse wave velocity measurement. Hypertens Res 25:359–364

    Article  PubMed  Google Scholar 

  14. Matsushima Y, Kawano H, Koide Y, Baba T, Toda G, Seto S, Yano K (2004) Relationship of carotid intima–media thickness, pulse wave velocity, and ankle brachial index to the severity of coronary artery atherosclerosis. Clin Cardiol 27:629–634

    Article  PubMed  Google Scholar 

  15. Wofford JL, Kahl FR, Howard GR, McKinney WM, Toole JF, Crouse JR 3rd (1991) Relation of extent of extracranial carotid artery atherosclerosis as measured by B-mode ultrasound to the extent of coronary atherosclerosis. Arterioscler Thromb 11:1786–1794

    Article  PubMed  CAS  Google Scholar 

  16. Craven TE, Ryu JE, Espeland MA, Kahl FR, McKinney WM, Toole JF, McMahan MR, Thompson CJ, Heiss G, Crouse JR 3rd (1990) Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis. A case-control study. Circulation 82:1230–1242

    Article  PubMed  CAS  Google Scholar 

  17. Tomiyama H, Yamashina A, Arai T, Hirose K, Koji Y, Chikamori T, Hori S, Yamamoto Y, Doba N, Hinohara S (2003) Influences of age and gender on results of noninvasive brachial–ankle pulse wave velocity measurement—a survey of 12517 subjects. Atherosclerosis 166:303–309

    Article  PubMed  CAS  Google Scholar 

  18. Sun Y, Lin CH, Lu CJ, Yip PK, Chen RC (2002) Carotid atherosclerosis, intima media thickness and risk factors—an analysis of 1781 asymptomatic subjects in Taiwan. Atherosclerosis 164:89–94

    Article  PubMed  CAS  Google Scholar 

  19. Tamaki Y, Araie M, Kawamoto E, Eguchi S, Fujii H (1995) Non-contact, two-dimensional measurement of tissue circulation in choroid and optic nerve head using laser speckle phenomenon. Exp Eye Res 60:373–383

    Article  PubMed  CAS  Google Scholar 

  20. Isono H, Kishi S, Kimura Y, Hagiwara N, Konishi N, Fujii H (2003) Observation of choroidal circulation using index of erythrocytic velocity. Arch Ophthalmol 121:225–231

    Article  PubMed  Google Scholar 

  21. Fujii H (1994) Visualisation of retinal blood flow by laser speckle flowgraphy. Med Biol Eng Comput 32:302–304

    Article  PubMed  CAS  Google Scholar 

  22. Shirai K, Utino J, Otsuka K, Takata M (2006) A novel blood pressure-independent arterial wall stiffness parameter; cardio–ankle vascular index (CAVI). J Atheroscler Thromb 13:101–107

    Article  PubMed  Google Scholar 

  23. Takiuchi S, Kamide K, Miwa Y, Tomiyama M, Yoshii M, Matayoshi T, Horio T, Kawano Y (2004) Diagnostic value of carotid intima–media thickness and plaque score for predicting target organ damage in patients with essential hypertension. J Hum Hypertens 18:17–23

    Article  PubMed  CAS  Google Scholar 

  24. O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr (1999) Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340:14–22

    Article  PubMed  Google Scholar 

  25. Ishikawa T, Hashimoto J, Morito RH, Hanazawa T, Aikawa T, Hara A, Shintani Y, Metoki H, Inoue R, Asayama K, Kikuya M, Ohkubo T, Totsune K, Hoshi H, Satoh H, Imai Y (2008) Association of microalbuminuria with brachial–ankle pulse wave velocity: the Ohasama study. Am J Hypertens 21:413–418

    Article  PubMed  CAS  Google Scholar 

  26. Sugiyama T, Araie M, Riva CE, Schmetterer L, Orgul S (2010) Use of laser speckle flowgraphy in ocular blood flow research. Acta Ophthalmol 88:723–729

    Article  PubMed  Google Scholar 

  27. Nagaoka T, Sato E, Takahashi A, Sogawa K, Yokota H, Yoshida A (2009) Effect of aging on retinal circulation in normotensive healthy subjects. Exp Eye Res 89:887–891

    Article  PubMed  CAS  Google Scholar 

  28. Nagaoka T, Ishii Y, Takeuchi T, Takahashi A, Sato E, Yoshida A (2005) Relationship between the parameters of retinal circulation measured by laser Doppler velocimetry and a marker of early systemic atherosclerosis. Invest Ophthalmol Vis Sci 46:720–725

    Article  PubMed  Google Scholar 

  29. Yambe M, Tomiyama H, Hirayama Y, Gulniza Z, Takata Y, Koji Y, Motobe K, Yamashina A (2004) Arterial stiffening as a possible risk factor for both atherosclerosis and diastolic heart failure. Hypertens Res 27:625–631

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

There was no sponsorship or other support for this study. The authors have no financial conflicts of interest. Involved in design and conduct of this study (T.S., M.T.); involved in collection, management, analysis, and interpretation of the data (T.S., M.T); involved in preparation, review, or approval of the manuscript (T.S., M.T., Y.H., T.M ). The institutional review board of Toho University Sakura Medical Center approved the study, and we began research after obtaining informed consent from all participants in accordance with the Declaration of Helsinki. We had no statistical consultation or assistance.

Conflict of interest

The authors have no proprietary or financial interest in any aspect of this report.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tomoaki Shiba.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shiba, T., Takahashi, M., Hori, Y. et al. Pulse-wave analysis of optic nerve head circulation is significantly correlated with brachial–ankle pulse-wave velocity, carotid intima–media thickness, and age. Graefes Arch Clin Exp Ophthalmol 250, 1275–1281 (2012). https://doi.org/10.1007/s00417-012-1952-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-012-1952-5

Keywords

Navigation