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The rate of myocardial infarction events among patients with age-related macular degeneration: a population-based study

  • Retinal Disorders
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Abstract

Purpose

To examine the association between age-related macular degeneration (AMD) and the risk of myocardial infarctions (MIs) in a large health maintenance organization.

Design

A retrospective cohort study carried out at Maccabi Healthcare Services (MHS).

Participants

A total of 6,546 patients aged ≥65 years who were diagnosed with AMD between April 18 1996 and June 6 2008, and 61,672 non-AMD patients frequency-matched for age and gender.

Methods

Participants were retrospectively followed to the day of leaving the MHS, to undergoing an MI, or to closure of the study on July 1 2008, whichever came earlier. The relative risk of MI associated with AMD was estimated using the Cox proportional hazard model.

Main Outcome Measures

Incident myocardial infarction events.

Results

During the study period, there were 159 (5.1 per 1,000 person years [PY]) and 2,997 (4.2 per 1,000 PY) MIs respecively in the AMD and non-AMD patient groups. The age- and gender-adjusted hazard ratio (HR) of MI among AMD patients was 1.01 (95%CI: 0.85–1.20). Baseline medical characteristics associated with increased risk of mortality included diabetes mellitus, hypertension, older age, and male gender. The fully adjusted HR associated with AMD was 1.03 (95%CI: 0.87–1.22).

Conclusion

Despite the shared risk factors associated with AMD and MIs, we found no increased risk of MI in AMD patients.

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Authors and Affiliations

  1. Department of Ophthalmology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, 64239, Israel

    Shani Golan, Michaela Goldstein & Anat Loewenstein

  2. Maccabi Health Care Services, Tel Aviv, Israel

    Varda Shalev, Giora Treister & Gabriel Chodick

  3. Sackler Faculty of Medicine, Tel Aviv University, Tel- Aviv, Israel

    Shani Golan, Varda Shalev, Michaela Goldstein, Giora Treister, Gabriel Chodick & Anat Loewenstein

Authors
  1. Shani Golan
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  2. Varda Shalev
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  3. Michaela Goldstein
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  4. Giora Treister
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  5. Gabriel Chodick
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  6. Anat Loewenstein
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Correspondence to Shani Golan.

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Golan, S., Shalev, V., Goldstein, M. et al. The rate of myocardial infarction events among patients with age-related macular degeneration: a population-based study. Graefes Arch Clin Exp Ophthalmol 249, 179–182 (2011). https://doi.org/10.1007/s00417-010-1489-4

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  • DOI: https://doi.org/10.1007/s00417-010-1489-4

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