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Direct admission versus secondary transfer for acute ischemic stroke patients treated with thrombectomy: a systematic review and meta-analysis

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Abstract

Background and purpose

Randomized controlled trials have demonstrated that mechanical thrombectomy (MT) could provide more benefit than standard medical care for acute ischemic stroke (AIS) patients due to emergent large vessel occlusion. However, most primary stroke centers (PSCs) are unable to perform MT, and MT can only be performed in comprehensive stroke centers (CSCs) with on-site interventional neuroradiologic services. Therefore, there is an ongoing debate regarding whether patients with suspected AIS should be directly admitted to CSCs or secondarily transferred to CSCs from PSCs. This meta-analysis was aimed to investigate the two transportation paradigms of direct admission and secondary transfer, which one could provide more benefit for AIS patients treated with MT.

Methods

We conducted a systematic review and meta-analysis through searching PubMed, Embase and the Cochrane Library database up to March 2020. Primary outcomes are as follows: symptomatic intracerebral hemorrhage (sICH) within 7 days; favorable functional outcome at 3 months; mortality in hospital; mortality at 3 months; and successful recanalization rate.

Results

Our pooled results showed that patients directly admitted to CSCs had higher chances of achieving a favorable functional outcome at 3 months than those secondarily transferred to CSCs (OR = 1.26; 95% CI, 1.12–1.42; P < 0.001). In addition, no significant difference was found between the two transportation paradigms in the rate of sICH (OR = 0.86; 95% CI, 0.62–1.18; P = 0.35), mortality in hospital (OR = 0.84; 95% CI, 0.51–1.39; P = 0.51), mortality at 3 months (OR = 1.01; 95% CI, 0.85–1.21; P = 0.91), and successful recanalization (OR = 1.03; 95% CI, 0.88–1.20; P = 0.74). However, in the 100% bridging thrombolysis usage rate subgroup, our subgroup analysis indicated that no difference was found in any outcome between the two transportation paradigms.

Conclusion

Patients with AIS directly admitted to CSCs for MT may be a feasible transportation paradigm for AIS patients. However, more large-scale randomized prospective trials are required to further investigate this issue.

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Author notes

  1. Weisong Zhao and Pengju Ma contributed equally.

Authors and Affiliations

  1. Department of Pediatrics, The First Clinic College of Xinxiang Medical University, Xinxiang, 453000, Henan, China

    Weisong Zhao & Jinbao Chen

  2. Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453000, Henan, China

    Pengju Ma

  3. School of Basic Medicine, Xinxiang Medical University, No.601 Jinsui Avenue, Xinxiang, 453000, China

    Xuejing Yue

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  1. Weisong Zhao
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Contributions

Weisong Zhao and Pengju Ma: literature search, data analysis, interpretation of the data, drafting and revision of the manuscript. Jinbao Chen: data analysis, interpretation of the data. Xuejing Yue: interpretation of the data, and critical revision of the manuscript.

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Correspondence to Xuejing Yue.

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Zhao, W., Ma, P., Chen, J. et al. Direct admission versus secondary transfer for acute ischemic stroke patients treated with thrombectomy: a systematic review and meta-analysis. J Neurol 268, 3601–3609 (2021). https://doi.org/10.1007/s00415-020-09877-2

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