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LRRK2 G2385R variant carriers of female Parkinson’s disease are more susceptible to motor fluctuation

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An Erratum to this article was published on 20 October 2013

Abstract

The relation between the LRRK2 mutation and its effect on Parkinson’s disease (PD) has always caught a lot attention. Recent studies found that the G2385R polymorphism of LRRK2 may increase the risk of PD in Asian populations. Here we tried to clarify the relationship between the LRRK2 G2385R variant and the clinical profiles including motor complication in Chinese PD patients. We identified the LRRK2 variant in the Chinese Han population in northern China and evaluated the relationship between the G2385R variant and clinical profiles through comparison between 36 carriers and 139 non-carriers. We found that G2385R carriers scored significantly higher in motor fluctuation and dyskinesia than non-carriers. Logistic regression analysis showed that the G2385R variant was an independent risk factor for motor fluctuation in females (odds ratio = 12.538, 95 % CI 2.216–70.942, P = 0.004), and a Chi-squared test showed that the frequency of dyskinesia tended to be higher in the carrier group compared to the non-carrier group (16 vs. 4.4 %, P = 0.050, OR = 4.127, 95 % CI 1.074–15.864). These findings indicate that the variant was closely related to the occurrence of motor complication. Additionally, the G2385R variant was significantly related to the early-onset of PD in female carriers (20.0 vs. 1.5 %, odds ratio = 16.25, 95 % CI 1.557–169.618, P = 0.020). Our study found that the G2385R variant was significantly associated with motor complications and that this variant was an independent risk factor for motor fluctuation in females. These findings provide the necessary preliminary data to better understand the unique profile of PD G2385R variant carriers.

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Acknowledgments

This work was funded by the National Nature Science Fund of China (No. 81371421, 30973153, 8141070 and 81000623), Liaoning Young Scholar Sponsor Plan (LJQ 2011081), and the Fundation of the Liaonig Educational Committee (L202013136, L2010560).

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Neurology Department of Shengjing Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China

    Chao Gao, Xiao-Guang Luo, Yan Ren & Zhi-Yi He

  2. Department of Forensic Serology, China Medical University, Shenyang, People’s Republic of China

    Hao Pang

  3. Department of Laboratory Medicine, First Affiliated Hospital of China Medical University, 155# Nanjing Bei Street, Heping District, Shenyang, 110001, People’s Republic of China

    Xiao-Guang Luo & Hong Shang

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  1. Chao Gao
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Correspondence to Xiao-Guang Luo.

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Gao, C., Pang, H., Luo, XG. et al. LRRK2 G2385R variant carriers of female Parkinson’s disease are more susceptible to motor fluctuation. J Neurol 260, 2884–2889 (2013). https://doi.org/10.1007/s00415-013-7086-9

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  • DOI: https://doi.org/10.1007/s00415-013-7086-9

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