Abstract
Impulse control and repetitive behavior disorders (ICRBs) are a group of diseases including impulse control disorder (ICD), repetitive behavior disorder (RB), and dopamine dysregulation syndrome (DDS). This study determined the prevalence and associated characteristics of ICRBs in Parkinson’s disease (PD) patients. Included were 297 patients, interviewed with the questionnaire for impulsive-compulsive disorders in PD for screening of various ICRBs. Questionnaire results and clinical characteristics were analyzed. The ICRB prevalence among PD patients was 15.5 % (46 of 297), with 35 patients with ICD, 20 with RB, and 7 with DDS. Patients with ICRB were predominantly male, younger, taking higher doses of dopaminergic drugs, and had longer disease duration, worse Unified Parkinson’s Disease Rating Scale (UPDRS) motor score, and worse PD quality of life questionnaire score. However, each ICRB subtype had different risk factor profiles. ICD patients were predominantly male, younger, had longer disease duration, were affected by PD from young age, were taking higher total dopaminergic drug dosages, and had more RB. RB patients had higher UPDRS part III scores, were taking higher levodopa doses, and had higher comorbid ICD. DDS patients were taking higher dopamine agonist doses, and had more frequent ICD. In multivariate logistic regression for secondary analysis, only younger age and comorbid RB or DDS showed significant association with ICD and only poor UPDRS III score and comorbid ICD were significantly associated with RB. These findings suggested that different risk factors contribute to development of each ICRB subtype. ICRB could be a combination of heterogeneous disease entities that need to be treated separately.
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References
Hoehn MM (1992) The natural history of Parkinson’s disease in the pre-levodopa and post-levodopa eras. Neurol Clin 10:331–339
Damasio AR, Lobo-Antunes J, Macedo C (1971) Psychiatric aspects in Parkinsonism treated with l-dopa. J Neurol Neurosurg Psychiatry 34:502–507
Evans AH, Lees AJ (2004) Dopamine dysregulation syndrome in Parkinson’s disease. Curr Opin Neurol 17:393–398
Voon V, Fox SH (2007) Medication-related impulse control and repetitive behaviors in Parkinson disease. Arch Neurol 64:1089–1096
Lim SY, Evans AH, Miyasaki JM (2008) Impulse control and related disorders in Parkinson’s disease: review. Ann N Y Acad Sci 1142:85–107
Pontone G, Williams JR, Bassett SS, Marsh L (2006) Clinical features associated with impulse control disorders in Parkinson disease. Neurology 67:1258–1261
Weintraub D, Koester J, Potenza MN et al (2010) Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients. Arch Neurol 67:589–595
Voon V, Sohr M, Lang AE et al (2011) Impulse control disorders in Parkinson disease: a multicenter case–control study. Ann Neurol 69:986–996
Weintraub D, Siderowf AD, Potenza MN et al (2006) Association of dopamine agonist use with impulse control disorders in Parkinson disease. Arch Neurol 63:969–973
Weintraub D, Hoops S, Shea JA et al (2009) Validation of the questionnaire for impulsive-compulsive disorders in Parkinson’s disease. Mov Disord 24:1461–1467
Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184
Herzog J, Volkmann J, Krack P et al (2003) Two-year follow-up of subthalamic deep brain stimulation in Parkinson’s disease. Mov Disord 18:1332–1337
Lee JY, Kim JM, Kim JW, Cho J, Lee WY, Kim HJ, Jeon BS (2010) Association between the dose of dopaminergic medication and the behavioral disturbances in Parkinson disease. Parkinsonism Relat Disord 16(3):202–207
Goetz CG, Poewe W, Rascol O, Sampaio C (2005) Evidence-based medical review update: pharmacological and surgical treatments of Parkinson’s disease: 2001 to 2004. Mov Disord 20:523–539
Voon V, Hassan K, Zurowski M et al (2006) Prevalence of repetitive and reward-seeking behaviors in Parkinson disease. Neurology 67:1254–1257
Avanzi M, Baratti M, Cabrini S, Uber E, Brighetti G, Bonfa F (2006) Prevalence of pathological gambling in patients with Parkinson’s disease. Mov Disord 21:2068–2072
Antonini A, Siri C, Santangelo G et al (2011) Impulsivity and compulsivity in drug naive patients with Parkinson’s disease. Mov Disord 26:464–468
Christenson GA, Faber RJ, de Zwaan M et al (1994) Compulsive buying: descriptive characteristics and psychiatric comorbidity. J Clin Psychiatry 55:5–11
O’Sullivan SS, Djamshidian A, Ahmed Z et al (2010) Impulsive-compulsive spectrum behaviors in pathologically confirmed progressive supranuclear palsy. Mov Disord 25:638–642
Miyasaki JM, Al Hassan K, Lang AE, Voon V (2007) Punding prevalence in Parkinson’s disease. Mov Disord 22:1179–1181
Evans AH, Katzenschlager R, Paviour D et al (2004) Punding in Parkinson’s disease: its relation to the dopamine dysregulation syndrome. Mov Disord 19:397–405
Lawrence AJ, Blackwell AD, Barker RA et al (2007) Predictors of punding in Parkinson’s disease: results from a questionnaire survey. Mov Disord 22:2339–2345
Wolters E, van der Werf YD, van den Heuvel OA (2008) Parkinson’s disease-related disorders in the impulsive-compulsive spectrum. J Neurol 255(Suppl 5):48–56
Groenewegen HJ, Berendse HW, Wolters JG, Lohman AH (1990) The anatomical relationship of the prefrontal cortex with the striatopallidal system, the thalamus and the amygdala: Evidence for a parallel organization. Prog Brain Res 85:95–116 (discussion 116–118)
Pezzella FR, Colosimo C, Vanacore N et al (2005) Prevalence and clinical features of hedonistic homeostatic dysregulation in Parkinson’s disease. Mov Disord 20:77–81
Giovannoni G, O’Sullivan JD, Turner K, Manson AJ, Lees AJ (2000) Hedonistic homeostatic dysregulation in patients with Parkinson’s disease on dopamine replacement therapies. J Neurol Neurosurg Psychiatry 68:423–428
Lim SY, Tan ZK, Ngam PI et al (2011) Impulsive-compulsive behaviors are common in Asian Parkinson’s disease patients: assessment using the quip. Parkinsonism Relat Disord 17:761–764
Koob GF, Le Moal M (1997) Drug abuse: hedonic homeostatic dysregulation. Science 278:52–58
Kalivas PW, Volkow ND (2005) The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 162:1403–1413
O’Sullivan SS, Evans AH, Lees AJ (2009) Dopamine dysregulation syndrome: an overview of its epidemiology, mechanisms and management. CNS drugs 23:157–170
Acknowledgments
We are grateful to Professor Daniel Weintraub for his permission of using the QUIP in this research. This study was supported by the basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2010-0027994).
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This study has been approved by the appropriate ethics committee and has, therefore, been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.
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Kim, J., Kim, M., Kwon, D.Y. et al. Clinical characteristics of impulse control and repetitive behavior disorders in Parkinson’s disease. J Neurol 260, 429–437 (2013). https://doi.org/10.1007/s00415-012-6645-9
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DOI: https://doi.org/10.1007/s00415-012-6645-9