Skip to main content

Advertisement

SpringerLink
Log in

Neural correlates of recovery from Foix–Chavany–Marie syndrome

  • Original Communication
  • Published:
Journal of Neurology Aims and scope Submit manuscript

Abstract

Cerebral reorganization during recovery after stroke has been investigated using functional imaging in patients with subcortical motor stroke. The functional correlates of recovery from anarthria, however, are yet unknown. A 48-year-old male patient recovering from complete anarthria after unilateral right-sided subcortical hemorrhagic stroke is described. The main outcome measures included clinical and neuroimaging data at three different time points (at the onset of symptoms, after 6 weeks and after 6 months). At 6 weeks, increased activations in the right and left frontal operculum were found and were followed by a trend towards normalization of the activation pattern at 6 months. These results suggest a role of anterior opercular regions in recovery from anarthria after subcortical stroke. Moreover, complete recovery is possible after such lesions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Assal G, Perentes E, Deruaz JP (1981) Crossed aphasia in a right-handed patient. Postmortem findings. Arch Neurol 38:455–458

    Article  PubMed  CAS  Google Scholar 

  2. Behrens TE, Johansen-Berg H, Woolrich MW, Smith SM, Wheeler-Kingshott CA, Boulby PA, Barker GJ, Sillery EL, Sheehan K, Ciccarelli O, Thompson AJ, Brady JM, Matthews PM (2003) Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat Neurosci 6:750–757

    Article  PubMed  CAS  Google Scholar 

  3. Bell DS (1968) Speech functions of the thalamus inferred from the effects of thalamotomy. Brain 91:619–638

    Article  PubMed  CAS  Google Scholar 

  4. Bogousslavsky J, Regli F (1990) Capsular genu syndrome. Neurology 40:1499–1502

    Article  PubMed  CAS  Google Scholar 

  5. Calautti C, Baron JC (2003) Functional neuroimaging studies of motor recovery after stroke in adults: a review. Stroke 34:1553–1566

    Article  PubMed  Google Scholar 

  6. Crosson B (1984) Role of the dominant thalamus in language: a review. Psychol Bull 96:491–517

    Article  PubMed  CAS  Google Scholar 

  7. Crosson B (1985) Subcortical functions in language: a working model. Brain Lang 25:257–292

    Article  PubMed  CAS  Google Scholar 

  8. Crosson B (1999) Subcortical mechanisms in language: lexical-semantic mechanisms and the thalamus. Brain Cogn 40:414–438

    Article  PubMed  CAS  Google Scholar 

  9. Crosson B, Benefield H, Cato MA, Sadek JR, Moore AB, Wierenga CE, Gopinath K, Soltysik D, Bauer RM, Auerbach EJ, Gokcay D, Leonard CM, Briggs RW (2003) Left and right basal ganglia and frontal activity during language generation: contributions to lexical, semantic, and phonological processes. J Int Neuropsychol Soc 9:1061–1077

    PubMed  Google Scholar 

  10. Duffau H, Denvil D, Capelle L (2002) Absence of movement disorders after surgical resection of glioma invading the right striatum. J Neurosurg 97:363–369

    Article  PubMed  Google Scholar 

  11. Duffau H, Karachi C, Gatignol P, Capelle L (2003) Transient Foix–Chavany–Marie syndrome after surgical resection of a right insulo-opercular low-grade glioma: case report. Neurosurgery 53:426–431

    Article  PubMed  Google Scholar 

  12. Foix C, Chavany JA, Marie J (1926) Diplégie facio-linguo-masticatrice d’origine cortico-sous-corticale sans paralysie des membres. Rev Neurol (Paris) 33:214–219

    Google Scholar 

  13. Geschwind N (1965) Disconnexion syndromes in animals and man. I. Brain 88:237–294

    Article  PubMed  CAS  Google Scholar 

  14. Geschwind N (1965) Disconnexion syndromes in animals and man. II. Brain 88:585–644

    Article  PubMed  CAS  Google Scholar 

  15. Gil RS, Gatignol P, Capelle L, Mitchell MC, Duffau H (2005) The role of dominant striatum in language: a study using intraoperative electrical stimulations. J Neurol Neurosurg Psychiatry 76:940–946

    Article  Google Scholar 

  16. Huber W, Klingenberg G, Poeck K, Willmes K (1993) Die supplemente zum aachener aphasie test—aufbau and resultate der validierung. Neurolinguistik 7:43–66

    Google Scholar 

  17. Huber W, Poeck K, Weniger D, Willmes K (1983) Aachener Aphasie Test (AAT). Hogrefe, Goettingen

  18. Johnson MD, Ojemann GA (2000) The role of the human thalamus in language and memory: evidence from electrophysiological studies. Brain Cogn 42:218–230

    Article  PubMed  CAS  Google Scholar 

  19. Kho KH, Indefrey P, Hagoort P, van Veelen CW, van Rijen PC, Ramsey NF (2008) Unimpaired sentence comprehension after anterior temporal cortex resection. Neuropsychologia 46:1170–1178

    Article  PubMed  CAS  Google Scholar 

  20. Kho KH, Leijten FS, Rutten GJ, Vermeulen J, Van RP, Ramsey NF (2005) Discrepant findings for Wada test and functional magnetic resonance imaging with regard to language function: use of electrocortical stimulation mapping to confirm results. Case report. J Neurosurg 102:169–173

    Article  PubMed  Google Scholar 

  21. Mao CC, Coull BM, Golper LA, Rau MT (1989) Anterior operculum syndrome. Neurology 39:1169–1172

    Article  PubMed  CAS  Google Scholar 

  22. Nelles G, Spiekramann G, Jueptner M, Leonhardt G, Muller S, Gerhard H, Diener HC (1999) Evolution of functional reorganization in hemiplegic stroke: a serial positron emission tomographic activation study. Ann Neurol 46:901–909

    Article  PubMed  CAS  Google Scholar 

  23. Penfield W, Boldrey E (1937) Somatic motor and sensory representation in the cerebral cortex of man as studied by electrical stimulation. Brain 60:389–443

    Article  Google Scholar 

  24. Saur D, Lange R, Baumgaertner A, Schraknepper V, Willmes K, Rijntjes M, Weiller C (2006) Dynamics of language reorganization after stroke. Brain 129:1371–1384

    Article  PubMed  Google Scholar 

  25. Starkstein SE, Berthier M, Leiguarda R (1988) Bilateral opercular syndrome and crossed aphemia due to a right insular lesion: a clinicopathological study. Brain Lang 34:253–261

    Article  PubMed  CAS  Google Scholar 

  26. Stippich C, Rapps N, Dreyhaupt J, Durst A, Kress B, Nennig E, Tronnier VM, Sartor K (2007) Localizing and lateralizing language in patients with brain tumors: feasibility of routine preoperative functional MR imaging in 81 consecutive patients. Radiology 243:828–836

    Article  PubMed  Google Scholar 

  27. Ter KM, Brown CM, Hagoort P, Stegeman DF (1999) Electrophysiological manifestations of open- and closed-class words in patients with Broca’s aphasia with agrammatic comprehension. An event-related brain potential study. Brain 122(Pt 5):839–854

    Google Scholar 

  28. Tombari D, Loubinoux I, Pariente J, Gerdelat A, Albucher JF, Tardy J, Cassol E, Chollet F (2004) A longitudinal fMRI study: in recovering and then in clinically stable sub-cortical stroke patients. Neuroimage 23:827–839

    Article  PubMed  Google Scholar 

  29. Ulmer JL, Hacein-Bey L, Mathews VP, Mueller WM, DeYoe EA, Prost RW, Meyer GA, Krouwer HG, Schmainda KM (2004) Lesion-induced pseudo-dominance at functional magnetic resonance imaging: implications for preoperative assessments. Neurosurgery 55:569–579

    Article  PubMed  Google Scholar 

  30. Ulmer JL, Krouwer HG, Mueller WM, Ugurel MS, Kocak M, Mark LP (2003) Pseudo-reorganization of language cortical function at fMR imaging: a consequence of tumor-induced neurovascular uncoupling. AJNR Am J Neuroradiol 24:213–217

    PubMed  Google Scholar 

  31. Vassal M, Le BE, Moritz-Gasser S, Menjot N, Duffau H (2010) Crossed aphasia elicited by intraoperative cortical and subcortical stimulation in awake patients. J Neurosurg 113:1251–1258

    Article  PubMed  Google Scholar 

  32. Warburton E, Price CJ, Swinburn K, Wise RJ (1999) Mechanisms of recovery from aphasia: evidence from positron emission tomography studies. J Neurol Neurosurg Psychiatry 66:155–161

    Article  PubMed  CAS  Google Scholar 

  33. Ward NS, Brown MM, Thompson AJ, Frackowiak RS (2003) Neural correlates of motor recovery after stroke: a longitudinal fMRI study. Brain 126:2476–2496

    Article  PubMed  CAS  Google Scholar 

  34. Wassenaar M, Brown CM, Hagoort P (2004) ERP effects of subject-verb agreement violations in patients with Broca’s aphasia. J Cogn Neurosci 16:553–576

    Article  PubMed  Google Scholar 

  35. Weller M (1993) Anterior opercular cortex lesions cause dissociated lower cranial nerve palsies and anarthria but no aphasia: Foix-Chavany-Marie syndrome and “automatic voluntary dissociation” revisited. J Neurol 240:199–208

    Article  PubMed  CAS  Google Scholar 

  36. Wise RJ, Greene J, Buchel C, Scott SK (1999) Brain regions involved in articulation. Lancet 353:1057–1061

    Article  PubMed  CAS  Google Scholar 

Download references

Conflicts of interest

The authors report no conflicts of interest.

Ethical standard

This study has been approved by the appropriate ethics committee and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium

    Tom Theys, Kuan H. Kho & Johannes van Loon

  2. Department of Neurology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium

    Anne-Catherine Vijverman

  3. Department of Radiology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium

    Sofie Van Cauter, Ronald R. Peeters & Stefan Sunaert

Authors
  1. Tom Theys
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sofie Van Cauter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kuan H. Kho
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anne-Catherine Vijverman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ronald R. Peeters
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Stefan Sunaert
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Johannes van Loon
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tom Theys.

Additional information

T. Theys, S. Van Cauter, K. H. Kho contributed equally to the manuscript.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Theys, T., Van Cauter, S., Kho, K.H. et al. Neural correlates of recovery from Foix–Chavany–Marie syndrome. J Neurol 260, 415–420 (2013). https://doi.org/10.1007/s00415-012-6641-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-012-6641-0

Keywords

Search

Navigation