Original Communication

Journal of Neurology

, Volume 258, Issue 3, pp 421-426

Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson’s disease? An analysis using the 13C-acetate breath test

  • Yuji TanakaAffiliated withDepartment of Neurology and Geriatrics, Graduate School of Medicine, Gifu UniversityFirst Department of Internal Medicine, Graduate School of Medicine, Gifu University Email author 
  • , Tomohiro KatoAffiliated withFirst Department of Internal Medicine, Graduate School of Medicine, Gifu University
  • , Hiroshi NishidaAffiliated withDepartment of Neurology and Geriatrics, Graduate School of Medicine, Gifu UniversityFirst Department of Internal Medicine, Graduate School of Medicine, Gifu University
  • , Megumi YamadaAffiliated withDepartment of Neurology and Geriatrics, Graduate School of Medicine, Gifu University
  • , Akihiro KoumuraAffiliated withDepartment of Neurology and Geriatrics, Graduate School of Medicine, Gifu University
  • , Takeo SakuraiAffiliated withDepartment of Neurology and Geriatrics, Graduate School of Medicine, Gifu University
  • , Yuichi HayashiAffiliated withDepartment of Neurology and Geriatrics, Graduate School of Medicine, Gifu University
  • , Akio KimuraAffiliated withDepartment of Neurology and Geriatrics, Graduate School of Medicine, Gifu University
  • , Isao HozumiAffiliated withDepartment of Neurology and Geriatrics, Graduate School of Medicine, Gifu University
    • , Hiroshi ArakiAffiliated withFirst Department of Internal Medicine, Graduate School of Medicine, Gifu University
    • , Masahiko MuraseAffiliated withFirst Department of Internal Medicine, Graduate School of Medicine, Gifu University
    • , Masahito NagakiAffiliated withFirst Department of Internal Medicine, Graduate School of Medicine, Gifu University
    • , Hisataka MoriwakiAffiliated withFirst Department of Internal Medicine, Graduate School of Medicine, Gifu University
    • , Takashi InuzukaAffiliated withDepartment of Neurology and Geriatrics, Graduate School of Medicine, Gifu University

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

During the pre-symptomatic stage of Parkinson’s disease (PD), the idiopathic PD related abnormal synuclein immunostaining is confined to the medulla oblongata and olfactory bulb, according to Braak. In the study of the enteric nervous system of PD, it has reported that Lewy bodies were found in the Auerbach’s and Meissner’s plexuses. These lesions may cause dysfunction of the gastrointestinal tract (GI) as pre-clinical symptoms of PD. However, because l-dopa therapy itself may worsen the symptoms of the digestive tract function, it is needed to evaluate the gastrointestinal tract function in patients with early-stage, untreated (de novo) PD. In the present study, using the 13C-acetate breath test (13C-ABT), we investigated gastric emptying in 20 untreated, early-stage PD patients and 40 treated, advanced-stage PD patients, and 20 healthy volunteers. Gastric emptying was examined by the 13C-ABT [the half emptying time (HET), the peak time of the 13C% dose-excess curve (T max)]. The T max and HET of gastric emptying as assessed using the 13C-ABT was significantly delayed in untreated, early-stage PD patients as compared to the controls (P < 0.001). The T max and HET of gastric emptying were not significantly delayed in untreated, early-stage PD patients as compared to treated, advanced-stage PD patients. The results demonstrated that delay in gastric emptying did not differ between untreated, early-stage and treated, advanced-stage PD patients. Gastric emptying of untreated, early-stage PD is already delayed. Delayed gastric emptying may be one of markers of the pre-clinical stage of PD.

Keywords

Parkinson’s disease Gastric emptying Untreated (de novo) early-stage 13C-acetate breath test