Journal of Neurology

, Volume 258, Issue 3, pp 421–426

Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson’s disease? An analysis using the 13C-acetate breath test

  • Yuji Tanaka
  • Tomohiro Kato
  • Hiroshi Nishida
  • Megumi Yamada
  • Akihiro Koumura
  • Takeo Sakurai
  • Yuichi Hayashi
  • Akio Kimura
  • Isao Hozumi
  • Hiroshi Araki
  • Masahiko Murase
  • Masahito Nagaki
  • Hisataka Moriwaki
  • Takashi Inuzuka
Original Communication

DOI: 10.1007/s00415-010-5769-z

Cite this article as:
Tanaka, Y., Kato, T., Nishida, H. et al. J Neurol (2011) 258: 421. doi:10.1007/s00415-010-5769-z

Abstract

During the pre-symptomatic stage of Parkinson’s disease (PD), the idiopathic PD related abnormal synuclein immunostaining is confined to the medulla oblongata and olfactory bulb, according to Braak. In the study of the enteric nervous system of PD, it has reported that Lewy bodies were found in the Auerbach’s and Meissner’s plexuses. These lesions may cause dysfunction of the gastrointestinal tract (GI) as pre-clinical symptoms of PD. However, because l-dopa therapy itself may worsen the symptoms of the digestive tract function, it is needed to evaluate the gastrointestinal tract function in patients with early-stage, untreated (de novo) PD. In the present study, using the 13C-acetate breath test (13C-ABT), we investigated gastric emptying in 20 untreated, early-stage PD patients and 40 treated, advanced-stage PD patients, and 20 healthy volunteers. Gastric emptying was examined by the 13C-ABT [the half emptying time (HET), the peak time of the 13C% dose-excess curve (Tmax)]. The Tmax and HET of gastric emptying as assessed using the 13C-ABT was significantly delayed in untreated, early-stage PD patients as compared to the controls (P < 0.001). The Tmax and HET of gastric emptying were not significantly delayed in untreated, early-stage PD patients as compared to treated, advanced-stage PD patients. The results demonstrated that delay in gastric emptying did not differ between untreated, early-stage and treated, advanced-stage PD patients. Gastric emptying of untreated, early-stage PD is already delayed. Delayed gastric emptying may be one of markers of the pre-clinical stage of PD.

Keywords

Parkinson’s diseaseGastric emptyingUntreated (de novo) early-stage13C-acetate breath test

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Yuji Tanaka
    • 1
    • 2
  • Tomohiro Kato
    • 2
  • Hiroshi Nishida
    • 1
    • 2
  • Megumi Yamada
    • 1
  • Akihiro Koumura
    • 1
  • Takeo Sakurai
    • 1
  • Yuichi Hayashi
    • 1
  • Akio Kimura
    • 1
  • Isao Hozumi
    • 1
  • Hiroshi Araki
    • 2
  • Masahiko Murase
    • 2
  • Masahito Nagaki
    • 2
  • Hisataka Moriwaki
    • 2
  • Takashi Inuzuka
    • 1
  1. 1.Department of Neurology and Geriatrics, Graduate School of MedicineGifu UniversityGifu CityJapan
  2. 2.First Department of Internal Medicine, Graduate School of MedicineGifu UniversityGifu CityJapan