Journal of Neurology

, Volume 258, Issue 3, pp 421–426

Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson’s disease? An analysis using the 13C-acetate breath test

Authors

    • Department of Neurology and Geriatrics, Graduate School of MedicineGifu University
    • First Department of Internal Medicine, Graduate School of MedicineGifu University
  • Tomohiro Kato
    • First Department of Internal Medicine, Graduate School of MedicineGifu University
  • Hiroshi Nishida
    • Department of Neurology and Geriatrics, Graduate School of MedicineGifu University
    • First Department of Internal Medicine, Graduate School of MedicineGifu University
  • Megumi Yamada
    • Department of Neurology and Geriatrics, Graduate School of MedicineGifu University
  • Akihiro Koumura
    • Department of Neurology and Geriatrics, Graduate School of MedicineGifu University
  • Takeo Sakurai
    • Department of Neurology and Geriatrics, Graduate School of MedicineGifu University
  • Yuichi Hayashi
    • Department of Neurology and Geriatrics, Graduate School of MedicineGifu University
  • Akio Kimura
    • Department of Neurology and Geriatrics, Graduate School of MedicineGifu University
  • Isao Hozumi
    • Department of Neurology and Geriatrics, Graduate School of MedicineGifu University
  • Hiroshi Araki
    • First Department of Internal Medicine, Graduate School of MedicineGifu University
  • Masahiko Murase
    • First Department of Internal Medicine, Graduate School of MedicineGifu University
  • Masahito Nagaki
    • First Department of Internal Medicine, Graduate School of MedicineGifu University
  • Hisataka Moriwaki
    • First Department of Internal Medicine, Graduate School of MedicineGifu University
  • Takashi Inuzuka
    • Department of Neurology and Geriatrics, Graduate School of MedicineGifu University
Original Communication

DOI: 10.1007/s00415-010-5769-z

Cite this article as:
Tanaka, Y., Kato, T., Nishida, H. et al. J Neurol (2011) 258: 421. doi:10.1007/s00415-010-5769-z

Abstract

During the pre-symptomatic stage of Parkinson’s disease (PD), the idiopathic PD related abnormal synuclein immunostaining is confined to the medulla oblongata and olfactory bulb, according to Braak. In the study of the enteric nervous system of PD, it has reported that Lewy bodies were found in the Auerbach’s and Meissner’s plexuses. These lesions may cause dysfunction of the gastrointestinal tract (GI) as pre-clinical symptoms of PD. However, because l-dopa therapy itself may worsen the symptoms of the digestive tract function, it is needed to evaluate the gastrointestinal tract function in patients with early-stage, untreated (de novo) PD. In the present study, using the 13C-acetate breath test (13C-ABT), we investigated gastric emptying in 20 untreated, early-stage PD patients and 40 treated, advanced-stage PD patients, and 20 healthy volunteers. Gastric emptying was examined by the 13C-ABT [the half emptying time (HET), the peak time of the 13C% dose-excess curve (T max)]. The T max and HET of gastric emptying as assessed using the 13C-ABT was significantly delayed in untreated, early-stage PD patients as compared to the controls (P < 0.001). The T max and HET of gastric emptying were not significantly delayed in untreated, early-stage PD patients as compared to treated, advanced-stage PD patients. The results demonstrated that delay in gastric emptying did not differ between untreated, early-stage and treated, advanced-stage PD patients. Gastric emptying of untreated, early-stage PD is already delayed. Delayed gastric emptying may be one of markers of the pre-clinical stage of PD.

Keywords

Parkinson’s disease Gastric emptying Untreated (de novo) early-stage 13C-acetate breath test

Copyright information

© Springer-Verlag 2010