ORIGINAL COMMUNICATION

Journal of Neurology

, Volume 253, Issue 9, pp 1165-1169

Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases

  • Luis Velázquez-PérezAffiliated withCentro para la Investigación y Rehabilitación de las Ataxias Hereditarias” Carlos J. Finlay”
  • , Juan Fernandez-RuizAffiliated withDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México
  • , Rosalinda DíazAffiliated withDepartamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México
  • , Ruth Pérez- GonzálezAffiliated withCentro para la Investigación y Rehabilitación de las Ataxias Hereditarias” Carlos J. Finlay”
  • , Nalia Canales OchoaAffiliated withCentro para la Investigación y Rehabilitación de las Ataxias Hereditarias” Carlos J. Finlay”
  • , Gilberto Sánchez CruzAffiliated withCentro para la Investigación y Rehabilitación de las Ataxias Hereditarias” Carlos J. Finlay”
  • , Luis Enrique Almaguer MederosAffiliated withCentro para la Investigación y Rehabilitación de las Ataxias Hereditarias” Carlos J. Finlay”
  • , Edilberto Martínez GóngoraAffiliated withCentro para la Investigación y Rehabilitación de las Ataxias Hereditarias” Carlos J. Finlay”
  • , Robyn HudsonAffiliated withDepartamento de Biología Celular y, Fisiología Instituto de Investigaciones Biomédicas, UNAM
    • , René Drucker-ColinAffiliated withDepartamento de Neurociencias, Instituto de Fisiología Celular, UNAM Email author 

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Abstract

Olfactory function is affected in different neurodegenerative diseases. Recently, it has been found that some hereditary ataxias are also associated with significant olfactory impairment. However, the initial findings did not examine the nature of the olfactory impairment associated with these ataxias. In the present article the effect of spinocerebellar ataxia type 2 (SCA2) on olfactory function was studied in 53 SCA2 patients and 53 healthy control subjects from Holguín, Cuba. Several tests were applied to evaluate olfactory threshold, description, identification and discrimination. The results show significant impairment in SCA2 patients on all olfactory measurements, and the pattern of olfactory deficits found suggests that they have much in common with those reported for other neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases.

Keywords

spinocerebellar ataxia olfactory function olfactory impairment neurodegenerative diseases