Factors associated with drug–induced visual hallucinations in Parkinson's disease
- S. PapapetropoulosAffiliated withDept. of Neurology, University of Miami, School of Medicine, Room 4004Dept. of Neurology, Regional University Hospital of Patras Email author
- , A. A. ArgyriouAffiliated withDept. of Neurology, Regional University Hospital of Patras
- , J. EllulAffiliated withDept. of Neurology, Regional University Hospital of Patras
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Visual hallucinations are common in medicationtreated Parkinson's disease (PD) patients. Although their etiology is unknown several factors seem to be involved in their pathogenesis. The aim of this study was to identify possible risk factors and determine clinical characteristics associated with the development of visual hallucinations in PD.
166 consecutive patients fulfilling clinical criteria for PD were studied. During a semi–structured interview, demographic characteristics and clinical variables were recorded. Motor, cognitive and psychiatric status was also assessed. Patients with and without visual hallucinations were compared using non–parametric tests, and logistic regression was applied to significant data.
During the month before evaluation 20.4% of our patients experienced visual hallucinations (11.4% benign, 9% malignant). Logistic regression analysis identified three factors independently associated with visual hallucinations: long duration of Parkinson's disease, dementia, and disease severity as measured by the UPDRS total score.
Our findings indicate that apart from well established risk factors such as cognitive impairment and disease duration, disease severity is also important for the development of visual hallucinations in PD. Furthermore, the presence of bradykinesia and instability, the absence of tremor and the severity of rigidity and bradykinesia (limb and axial) may act as cofactors.
Key wordsParkinson's disease hallucinations risk factors clinical phenotype
- Factors associated with drug–induced visual hallucinations in Parkinson's disease
Journal of Neurology
Volume 252, Issue 10 , pp 1223-1228
- Cover Date
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- Parkinson's disease
- risk factors
- clinical phenotype
- Industry Sectors
- Author Affiliations
- 1. Dept. of Neurology, University of Miami, School of Medicine, Room 4004, 1501 NW 9th Avenue, 33136 Miami (FL), USA
- 2. Dept. of Neurology, Regional University Hospital of Patras, Patras, Greece