Journal of Neurology

, Volume 250, Issue 4, pp 440–443

Positional vertigo and macroscopic downbeat positioning nystagmus in spinocerebellar ataxia type 6 (SCA6)

Authors

  • Ichiro Yabe
    • Department of Neurology, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo 060-8638, Japan. hsasaki@med.hokudai.ac.jp
  • Hidenao Sasaki
    • Department of Neurology, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo 060-8638, Japan. hsasaki@med.hokudai.ac.jp
  • Norihito Takeichi
    • Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • Asako Takei
    • Hokuyukai Neurology Hospital, Sapporo, Japan
  • Takeshi Hamada
    • Hokuyukai Neurology Hospital, Sapporo, Japan
  • Kikuro Fukushima
    • Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • Kunio Tashiro
    • Department of Neurology, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo 060-8638, Japan. hsasaki@med.hokudai.ac.jp
ORIGINAL COMMUNICATION

DOI: 10.1007/s00415-003-1020-5

Cite this article as:
Yabe, I., Sasaki, H., Takeichi, N. et al. J Neurol (2003) 250: 440. doi:10.1007/s00415-003-1020-5

Abstract.

To investigate the frequency of positioning nystagmus in degenerative ataxic disorders, we examined downbeat positioning nystagmus (DPN) in 25 patients with spinocerebellar ataxia type 6 (SCA6) and 58 patients with other types of degenerative ataxia. DPN was observed in 21 of the 25 patients with SCA6 (84 %) versus only 3 of the 58 patients (5.2 %) with other types of degenerative ataxia, including multiple system atrophy, SCA1, SCA2, SCA3/Machado-Joseph disease, and non-SCA6 late-onset pure cerebellar ataxia. Our findings indicated that DPN is a distinct part of the clinical presentation of SCA6, showing that vestibular cerebellum is more affected in SCA6 than other types of degenerative ataxia.

Key words spinocerebellar ataxia type 6downbeat nystagmuspositional vertigooscillopsiavestibulo-ocular reflex

Copyright information

© Steinkopff Verlag 2003