Journal of Neurology

, Volume 250, Issue 4, pp 440–443

Positional vertigo and macroscopic downbeat positioning nystagmus in spinocerebellar ataxia type 6 (SCA6)

Authors

  • Ichiro Yabe
    • Department of Neurology, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo 060-8638, Japan. hsasaki@med.hokudai.ac.jp
  • Hidenao Sasaki
    • Department of Neurology, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo 060-8638, Japan. hsasaki@med.hokudai.ac.jp
  • Norihito Takeichi
    • Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • Asako Takei
    • Hokuyukai Neurology Hospital, Sapporo, Japan
  • Takeshi Hamada
    • Hokuyukai Neurology Hospital, Sapporo, Japan
  • Kikuro Fukushima
    • Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • Kunio Tashiro
    • Department of Neurology, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo 060-8638, Japan. hsasaki@med.hokudai.ac.jp
ORIGINAL COMMUNICATION

DOI: 10.1007/s00415-003-1020-5

Cite this article as:
Yabe, I., Sasaki, H., Takeichi, N. et al. J Neurol (2003) 250: 440. doi:10.1007/s00415-003-1020-5

Abstract.

To investigate the frequency of positioning nystagmus in degenerative ataxic disorders, we examined downbeat positioning nystagmus (DPN) in 25 patients with spinocerebellar ataxia type 6 (SCA6) and 58 patients with other types of degenerative ataxia. DPN was observed in 21 of the 25 patients with SCA6 (84 %) versus only 3 of the 58 patients (5.2 %) with other types of degenerative ataxia, including multiple system atrophy, SCA1, SCA2, SCA3/Machado-Joseph disease, and non-SCA6 late-onset pure cerebellar ataxia. Our findings indicated that DPN is a distinct part of the clinical presentation of SCA6, showing that vestibular cerebellum is more affected in SCA6 than other types of degenerative ataxia.

Key words spinocerebellar ataxia type 6 downbeat nystagmus positional vertigo oscillopsia vestibulo-ocular reflex

Copyright information

© Steinkopff Verlag 2003