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Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding

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Abstract.

We used single photon emission computed tomography (SPECT) to study striatal [123I]β-CIT binding and polysomnography to study periodic leg movements during sleep (PLMS) in eleven patients with idiopathic Parkinson's disease (PD). The reduced striatal [123I]β-CIT binding was significantly correlated with the number of PLMS. We propose that striatal dopaminergic nerve cell loss is involved in the increased number of PLMS in PD patients.

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Authors and Affiliations

  1. Department of Clinical Neurophysiology, Robert-Koch-Strasse 40, 37075 Goettingen, Germany. shappe@gwdg.de, , , , , , DE

    Svenja Happe

  2. Department of Clinical Neurology, University of Vienna, Austria, , , , , , AT

    Walter Pirker, Gerhard Klösch, Cornelia Sauter & Josef Zeitlhofer

Authors
  1. Svenja Happe
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  2. Walter Pirker
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  3. Gerhard Klösch
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  4. Cornelia Sauter
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  5. Josef Zeitlhofer
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Additional information

Received: 26 April 2002, Received in revised form: 21 August 2002, Accepted: 29 August 2002

Correspondence to Svenja Happe, MD

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Happe, S., Pirker, W., Klösch, G. et al. Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding. J Neurol 250, 83–86 (2003). https://doi.org/10.1007/s00415-003-0957-8

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  • DOI: https://doi.org/10.1007/s00415-003-0957-8

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