ORIGINAL COMMUNICATION

Journal of Neurology

, Volume 250, Issue 9, pp 1094-1098

Apolipoprotein E genotype does not influence the progression of multiple sclerosis

  • Giovanni SavettieriMDAffiliated withInstitute of Neuropsychiatry, University of Palermo
  • , Virginia AndreoliPhDAffiliated withInstitute of Neurological Sciences, National Research Council
  • , Simona BonavitaMDAffiliated withDept. of Neurological Sciences, 2nd University of Naples
  • , Rita CittadellaPhDAffiliated withInstitute of Neurological Sciences, National Research Council
  • , Carlo CaltagironeMDAffiliated withCattedra di Neurologia and I.R.C.C.S., Fondazione "S. Lucia", University of Rome "Tor Vergata"
  • , Maria Carolina FazioMDAffiliated withDept. of Neurosciences, Psychiatry and Anaesthesiology, University of Messina
  • , Paolo GirlandaMDAffiliated withDept. of Neurosciences, Psychiatry and Anaesthesiology, University of Messina
  • , Francesco Le PiraMDAffiliated withDept. of Neurological Sciences, University of Catania
  • , Maria LiguoriMDAffiliated withDept. of Neurological and Psychiatric Sciences, University of Bari
    • , Giancarlo LogroscinoMDAffiliated withDept. of Neurology, Ospedale Miulli
    • , Alessandra LugaresiMDAffiliated withDept. of Oncology & Neuroscience, University of Chieti "Gabriele d’Annunzio"
    • , Ugo NocentiniMDAffiliated withCattedra di Neurologia and I.R.C.C.S., Fondazione "S. Lucia", University of Rome "Tor Vergata"
    • , Arturo ReggioMDAffiliated withDept. of Neurological Sciences, University of Catania
    • , Giuseppe SalemiMDAffiliated withInstitute of Neuropsychiatry, University of Palermo
    • , Paolo SerraPhDAffiliated withInstitute of Neurological Sciences, National Research Council
    • , Gioacchino TedeschiMDAffiliated withDept. of Neurological Sciences, 2nd University of Naples
    • , Lucia TomaMDAffiliated withDept. of Oncology & Neuroscience, University of Chieti "Gabriele d’Annunzio"
    • , Maria TrojanoMDAffiliated withDept. of Neurological and Psychiatric Sciences, University of Bari
    • , Paola ValentinoMDAffiliated withInstitute of Neuropsychiatry, University of PalermoInstitute of Neurology, University Magna Graecia
    • , Aldo QuattroneMDAffiliated withInstitute of Neuropsychiatry, University of PalermoInstitute of Neurological Sciences, National Research CouncilInstitute of Neurology, University Magna GraeciaClinica Neurologica, Policlinico Mater Domini Email author 

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Abstract.

Objective:

To investigate the association between apolipoprotein E (APOE) polymorphisms and the progression of MS.

Methods:

We investigated 428 subjects affected by clinically defined MS, with a disease duration of at least three years. We collected data concerning the age at onset of MS, clinical type, disease duration and disability according to the expanded disability status scale (EDSS). We also calculated the progression index (PI) to evaluate disease progression. APOE genotyping and the –491 A/T polymorphism of the APOE promoter were determined.

Results:

No association was observed between the APOE ε4 allele and clinical characteristics of our study population. We also investigated the –491 A/T APOE promoter polymorphism in 236 MS subjects and did not find any association between the –491 A/T polymorphism and the selected clinical variables.

Conclusions:

In our population the APOE ε4 allele and the –491 A/T APOE promoter polymorphism are not associated with a more rapid course of MS.

Key words

multiple sclerosis APOE polymorphism APOE promoter MS progression