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Elevated striatal dopamine transporter in a drug naive patient with Tourette syndrome and attention deficit/hyperactivity disorder: positive effect of methylphenidate

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References

  1. Brown TE (1996) Brown attention deficit disorder scales. The Psychological Corporation, San Antonio, TX

    Google Scholar 

  2. Dresel S, Krause J, Krause KH, LaFougere C, Brinkbäumer K, Kung HF, Hahn K, Tatsch K (2000) Attention deficit hyperactivity disorder: binding of[99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment. Eur J Nucl Med 27: 1518–1524

    Article  CAS  PubMed  Google Scholar 

  3. Gadow KD, Sverd J, Sprafkin J, Nolan EE, Grossman S (1999) Long-term methylphenidate therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder. Arch Gen Psychiatry 56: 330–336

    Article  CAS  PubMed  Google Scholar 

  4. Krause KH, Dresel SH, Krause J, Kung HF, Tatsch K (2000) Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography. Neurosci Lett 285: 107–110

    Article  CAS  PubMed  Google Scholar 

  5. Kung HF, Kim HJ, Kung MP, Meegalla SK, Plössl K, Lee HK (1996) Imaging of dopamine transporters in humans with technetium-99m TRODAT-1. Eur J Nucl Med 23: 1527–1530

    Article  CAS  PubMed  Google Scholar 

  6. Kurlan R, Tourette Syndrome Study Group (2000) Treatment of attentiondeficit hyperactivity disorder in children with Tourette’s syndrome (TACT trial). Ann Neurol 48: 953A

    Google Scholar 

  7. Malison RT, McDougle CJ, van Dyck CH, Scahill L, Baldwin RM, Seibyl JP, Price LH, Leckman JF, Innis RB (1995) [123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette’s disorder. Am J Psychiatry 152: 1359–1361

    CAS  PubMed  Google Scholar 

  8. Meyer P, Bohnen NI, Minoshima S, Koeppe RA, Wernette K, Kilbourn MR, Kuhl DE, Frey KA, Albin RL (1999) Striatal presynaptic monoaminergic vesicles are not increased in Tourette’s syndrome. Neurology 53: 371–374

    Article  CAS  PubMed  Google Scholar 

  9. Müller-Vahl KR, Berding G, Brucke T, Kolbe H, Meyer GJ, Hundeshagen H, Dengler R, Knapp WH, Emrich HM (2000) Dopamine transporter binding in Gilles de la Tourette syndrome. J Neurol 247: 514–520

    Article  PubMed  Google Scholar 

  10. Russell VA, de Villiers AS, Sagvolden T, Lamm MC, Taljaard JJ (2000) Methylphenidate affects striatal dopamine differently in an animal model for attention-deficit/hyperactivity disorder — the spontaneously hypertensive rat. Brain Res Bull 53: 187–192

    Article  CAS  PubMed  Google Scholar 

  11. Singer HS, Hahn IH, Moran TH (1991) Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette’s syndrome. Ann Neurol 30: 558–562

    Article  CAS  PubMed  Google Scholar 

  12. Stamenkovic M, Schindler SD, Asenbaum S, Neumeister A, Willeit M, Willinger U, de Zwaan M, Riederer F, Aschauer HN, Kasper S (2001) No change in striatal dopamine re-uptake site density in psychotropic drug naïve and in currently treated Tourette’s disorder patients: a [123I]beta-CIT SPECT-study. Eur Neuropsychopharmacol 11: 69–74

    Article  CAS  PubMed  Google Scholar 

  13. Ward MF, Wender PH, Reimherr FW (1993) The Wender Utah Rating Scale: An aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am J Psychiatry 150: 885–890

    CAS  PubMed  Google Scholar 

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Correspondence to Klaus-Henning Krause MD.

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Krause, KH., Dresel, S., Krause, J. et al. Elevated striatal dopamine transporter in a drug naive patient with Tourette syndrome and attention deficit/hyperactivity disorder: positive effect of methylphenidate. J Neurol 249, 1116–1118 (2002). https://doi.org/10.1007/s00415-002-0746-9

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  • DOI: https://doi.org/10.1007/s00415-002-0746-9

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