Short Communication

International Journal of Legal Medicine

, Volume 122, Issue 3, pp 251-255

Analysis of Y-chromosomal SNP haplogroups and STR haplotypes in an Algerian population sample

  • C. RobinoAffiliated withDepartment of Anatomy, Pharmacology and Legal Medicine, University of Turin Email author 
  • , F. CrobuAffiliated withDepartment of Genetics, Biology and Biochemistry, University of Turin
  • , C. Di GaetanoAffiliated withDepartment of Genetics, Biology and Biochemistry, University of Turin
  • , A. BekadaAffiliated withDépartement de Biotechnologie, Faculté des Sciences, Université d’Oran
  • , S. BenhamamouchAffiliated withDépartement de Biotechnologie, Faculté des Sciences, Université d’Oran
  • , N. CeruttiAffiliated withDepartment of Genetics, Biology and Biochemistry, University of Turin
  • , A. PiazzaAffiliated withDepartment of Genetics, Biology and Biochemistry, University of Turin
  • , S. InturriAffiliated withDepartment of Anatomy, Pharmacology and Legal Medicine, University of Turin
  • , C. TorreAffiliated withDepartment of Anatomy, Pharmacology and Legal Medicine, University of Turin

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Abstract

The distribution of Y-chromosomal single nucleotide polymorphism (SNP) haplogroups and short tandem repeat (STR) haplotypes was determined in a sample of 102 unrelated men of Arab origin from northwestern Algeria (Oran area). A total of nine different haplogroups were identified by a panel of 22 binary markers. The most common haplogroups observed in the Algerian population were E3b2 (45.1%) and J1 (22.5%). Y-STR typing by a 17-loci multiplex system allowed 93 haplotypes to be defined (88 were unique). Striking differences in the allele distribution and gene diversity of Y-STR markers between haplogroups could be found. In particular, intermediate alleles at locus DYS458 specifically characterized the haplotypes of individuals carrying haplogroup J1. All the intermediate alleles shared a common repeat sequence structure, supporting the hypothesis that the variant originated from a single mutational event.

Keywords

Y chromosome Single nucleotide polymorphism Short tandem repeat Algeria DYS458