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Mitochondrial DNA CA dinucleotide repeats in Koreans: the presence of length heteroplasmy

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Abstract

The mitochondrial DNA HV3 region contains CA dinucleotide repeats which display length polymorphism. To analyze this for forensic purposes, we designed a fluorescence-labelled PCR primer set for short amplification products and carried out genotyping by using capillary electrophoresis. A total of 4 alleles with 4–7 repeat units were observed and the genetic diversity was estimated to be 0.5120 in 500 unrelated Koreans. Interestingly, three individuals showed two or three length variants, i.e. length heteroplasmy.

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Fig. 1A–D

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Acknowledgements

This work was supported by a grant from the Korea Science and Engineering Foundation (KOSEF) through the Biometrics Engineering Research Center (BERC) at Yonsei University.

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Authors and Affiliations

  1. Department of Forensic Medicine and Brain Korea 21 Project for Medical Science, College of Medicine Yonsei University, 134 Shinchon-Dong Seodaemun-Gu, 120–752, Seoul , Korea

    Ukhee Chung, Hwan Young Lee, Ji-Eun Yoo, Myung Jin Park & Kyoung-Jin Shin

  2. Biometrics Engineering Research Center, Yonsei University, 134 Shinchon-Dong Seodaemun-Gu, 120–749, Seoul, Korea

    Ukhee Chung & Kyoung-Jin Shin

  3. Human Identification Research Institute, Yonsei University, 134 Shinchon-Dong Seodaemun-Gu, 120–752, Seoul , Korea

    Kyoung-Jin Shin

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  1. Ukhee Chung
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  2. Hwan Young Lee
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  3. Ji-Eun Yoo
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  4. Myung Jin Park
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  5. Kyoung-Jin Shin
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Correspondence to Kyoung-Jin Shin.

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Chung, U., Lee, H.Y., Yoo, JE. et al. Mitochondrial DNA CA dinucleotide repeats in Koreans: the presence of length heteroplasmy. Int J Legal Med 119, 50–53 (2005). https://doi.org/10.1007/s00414-004-0487-7

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  • DOI: https://doi.org/10.1007/s00414-004-0487-7

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